ID D6KCJ3_9ACTN Unreviewed; 808 AA.
AC D6KCJ3;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Regulatory protein AfsR {ECO:0000313|EMBL:EFF88798.2};
GN ORFNames=SSTG_04668 {ECO:0000313|EMBL:EFF88798.2};
OS Streptomyces sp. e14.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=645465 {ECO:0000313|EMBL:EFF88798.2, ECO:0000313|Proteomes:UP000004704};
RN [1] {ECO:0000313|EMBL:EFF88798.2, ECO:0000313|Proteomes:UP000004704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=e14 {ECO:0000313|Proteomes:UP000004704};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center;
RA Fischbach M., Godfrey P., Ward D., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A.M., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Richards J.,
RA Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N.,
RA Thomson T., Walk T., White J., Yandava C., Straight P., Clardy J., Hung D.,
RA Kolter R., Mekalanos J., Walker S., Walsh C.T., Wieland-Brown L.C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Streptomyces sp. strain e14.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG753627; EFF88798.2; -; Genomic_DNA.
DR AlphaFoldDB; D6KCJ3; -.
DR STRING; 645465.SSTG_04668; -.
DR eggNOG; COG3629; Bacteria.
DR eggNOG; COG3903; Bacteria.
DR Proteomes; UP000004704; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF13560; HTH_31; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000004704};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 210..306
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 210..306
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 808 AA; 86686 MW; 5EF417EC8F36D964 CRC64;
MAAVGRKEKP IVASNRALVR LARWLRDQRS ASRCSYAELA VRAGCHATTL QRAASGRSVP
SARTVRAYAA ACGASQEVAT ELWRQARRRT ARNTAVGSPL DIDGIDMFRA GLRELYEAAG
RPSMRDMERA GGPGRLPHST AHRIVTGLTV PRDVHQLTGF LTACSVAERE HPGWVDAWRR
ALGQDTALAL APRKISPTIR KSVPSAGATR DLTPVSGPCF ALLGPVRAWR DNQPMATGSP
QQRALLAVLL LREGRMATAA ELIDALWGEE PPPQALAAVR TYASRLRKTL GSDVLVGEAG
GYAVRGLDAD ALDLTTAREL ATEADRARTA GDLRHARSLL GRALALWDGE PLAGLPGPHA
EAQRARLQEW RMQLLESRLD MDLEQGCHAE AVSELTVLTA VHPLRERLRE LLMLALYRSG
RQAEALAVYA DTRRLLADEL GVDPRPELRE LQQRILQADP ALAEPSAPAP MPPAQLPASV
PDFTGRAASV AELSEVLASA QGRVMAVSAL VGIGGVGKTT LAVHVAHQAR AAFPDGQLYV
ALEGSGQRAA EPNTVLGSFL RALGTADSAI PDSLEERAAM YRSVLAGRRV LVLLDDARDA
AQVRPLLPGT DGCAALVTSR ARMTDLAGAH RLELDEMSPQ EALTLFTKIV GEERVAAERE
AALDVVAAGG FLPLAIRIAA SRLAARRTWT VSVLAAKLAD ERSRLDELRA GDLAVGSVFE
RSYGRLDEEQ ARAFCLLSST ALPFLSLPQS ASLLNRGIAE TGGLMESLVD AGLLIPMGPE
HYQVHRLARL VGAAHFGEWR SPQEPWPP
//
