ID D6RAY3_HUMAN Unreviewed; 46 AA.
AC D6RAY3;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=5-methyltetrahydrofolate-homocysteine methyltransferase reductase {ECO:0000313|Ensembl:ENSP00000424644.1};
GN Name=MTRR {ECO:0000313|Ensembl:ENSP00000424644.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424644.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000424644.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0000313|Ensembl:ENSP00000424644.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC010346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D6RAY3; -.
DR SMR; D6RAY3; -.
DR MassIVE; D6RAY3; -.
DR MaxQB; D6RAY3; -.
DR PeptideAtlas; D6RAY3; -.
DR ProteomicsDB; 13466; -.
DR Ensembl; ENST00000503550.5; ENSP00000424644.1; ENSG00000124275.15.
DR UCSC; uc063ceo.1; human.
DR HGNC; HGNC:7473; MTRR.
DR VEuPathDB; HostDB:ENSG00000124275; -.
DR GeneTree; ENSGT00940000155822; -.
DR ChiTaRS; MTRR; human.
DR Proteomes; UP000005640; Chromosome 5.
DR Bgee; ENSG00000124275; Expressed in endothelial cell and 199 other cell types or tissues.
DR ExpressionAtlas; D6RAY3; baseline and differential.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR Gene3D; 3.40.50.360; -; 1.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:D6RAY3,
KW ECO:0007829|MaxQB:D6RAY3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 4..46
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
SQ SEQUENCE 46 AA; 5169 MW; 2F137D1ADD7C6DD7 CRC64;
MRRFLLLYAT QQGQAKAIAE EICEQAVVHG FSADLHCISE SDKCEK
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