ID D6RB43_HUMAN Unreviewed; 195 AA.
AC D6RB43;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=FERM domain containing 1 {ECO:0000313|Ensembl:ENSP00000424439.2};
DE Flags: Fragment;
GN Name=FRMD1 {ECO:0000313|Ensembl:ENSP00000424439.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424439.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000424439.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000424439.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL589733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D6RB43; -.
DR SMR; D6RB43; -.
DR PeptideAtlas; D6RB43; -.
DR ProteomicsDB; 13522; -.
DR Antibodypedia; 33557; 77 antibodies from 13 providers.
DR Ensembl; ENST00000511714.2; ENSP00000424439.2; ENSG00000153303.18.
DR UCSC; uc063syo.1; human.
DR HGNC; HGNC:21240; FRMD1.
DR VEuPathDB; HostDB:ENSG00000153303; -.
DR GeneTree; ENSGT00940000162787; -.
DR HOGENOM; CLU_1499638_0_0_1; -.
DR OMA; SYGCVYS; -.
DR ChiTaRS; FRMD1; human.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000153303; Expressed in mucosa of transverse colon and 91 other cell types or tissues.
DR ExpressionAtlas; D6RB43; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd17197; FERM_F1_FRMD1; 1.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR047145; FRMD6-like.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13429; FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY; 1.
DR PANTHER; PTHR13429:SF7; FERM DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 96..195
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 195
FT /evidence="ECO:0000313|Ensembl:ENSP00000424439.2"
SQ SEQUENCE 195 AA; 22381 MW; 4E4F8EF4291F0C25 CRC64;
METSRPEEER VGPRRTPGLS HEEIWAVVSS SSRPLPVHCP ALTSRTWQAS LFHHEQASRE
DKTFRGARCM EPSPERPACS QQEPTLGMDA MASEHRDVLV LLPSREQLRL AVGVKATGRE
LFQQVCNVAS IRDAQFFGLC VVRNNEYIFM DLEQKLSKYF SKDWKKERNE GNEKPRAPFV
AFLRVQHYVE NGRVI
//
