ID D6REM0_HUMAN Unreviewed; 117 AA.
AC D6REM0;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Gamma-aminobutyric acid type A receptor subunit beta1 {ECO:0000313|Ensembl:ENSP00000426753.1};
DE Flags: Fragment;
GN Name=GABRB1 {ECO:0000313|Ensembl:ENSP00000426753.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000426753.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000426753.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000426753.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC097712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC105394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D6REM0; -.
DR SMR; D6REM0; -.
DR MassIVE; D6REM0; -.
DR PeptideAtlas; D6REM0; -.
DR ProteomicsDB; 14336; -.
DR Antibodypedia; 12048; 501 antibodies from 40 providers.
DR Ensembl; ENST00000513567.5; ENSP00000426753.1; ENSG00000163288.14.
DR UCSC; uc062wje.1; human.
DR HGNC; HGNC:4081; GABRB1.
DR VEuPathDB; HostDB:ENSG00000163288; -.
DR GeneTree; ENSGT00940000154245; -.
DR HOGENOM; CLU_010920_5_2_1; -.
DR OMA; YWQGGSN; -.
DR ChiTaRS; GABRB1; human.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000163288; Expressed in Brodmann (1909) area 23 and 126 other cell types or tissues.
DR ExpressionAtlas; D6REM0; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR PANTHER; PTHR18945:SF429; GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-1; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:D6REM0,
KW ECO:0007829|ProteomicsDB:D6REM0};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 6..117
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT NON_TER 117
FT /evidence="ECO:0000313|Ensembl:ENSP00000426753.1"
SQ SEQUENCE 117 AA; 13530 MW; B3F1A381FF751F07 CRC64;
MSYVKETVDR LLKGYDIRLR PDFGGPPVDV GMRIDVASID MVSEVNMDYT LTMYFQQSWK
DKRLSYSGIP LNLTLDNRVA DQLWVPDTYF LNDKKSFVHG VTVKNRMIRL HPDGTVL
//
