ID D6RGY7_HUMAN Unreviewed; 95 AA.
AC D6RGY7;
DT 13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT 13-JUL-2010, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Potassium calcium-activated channel subfamily N member 2 {ECO:0000313|Ensembl:ENSP00000421095.1};
GN Name=KCNN2 {ECO:0000313|Ensembl:ENSP00000421095.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000421095.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000421095.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000421095.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC025761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC094088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC106789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC113364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; D6RGY7; -.
DR SMR; D6RGY7; -.
DR MassIVE; D6RGY7; -.
DR PeptideAtlas; D6RGY7; -.
DR Ensembl; ENST00000505491.1; ENSP00000421095.1; ENSG00000080709.17.
DR UCSC; uc063gci.1; human.
DR HGNC; HGNC:6291; KCNN2.
DR VEuPathDB; HostDB:ENSG00000080709; -.
DR GeneTree; ENSGT00950000182904; -.
DR HOGENOM; CLU_2372186_0_0_1; -.
DR ChiTaRS; KCNN2; human.
DR Proteomes; UP000005640; Chromosome 5.
DR Bgee; ENSG00000080709; Expressed in secondary oocyte and 150 other cell types or tissues.
DR ExpressionAtlas; D6RGY7; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR10153:SF33; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..49
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 70..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 95 AA; 10635 MW; C38FA0DB894CEDDD CRC64;
MWLISITFLS IGYGDMVPNT YCGKGVCLLT GIMGAGCTAL VVAVVARKLE LTKAEKHVHN
FMMDTQLTKR GKEDHGDNNC NTRWRTQHPL IKKKK
//
