ID D6W6H7_TRICA Unreviewed; 1233 AA.
AC D6W6H7;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Serine protease P54 {ECO:0000313|EMBL:EFA11570.2};
GN Name=AUGUSTUS-3.0.2_04654 {ECO:0000313|EMBL:EFA11570.2};
GN ORFNames=TcasGA2_TC004654 {ECO:0000313|EMBL:EFA11570.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA11570.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA11570.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11570.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA11570.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA11570.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ971307; EFA11570.2; -; Genomic_DNA.
DR AlphaFoldDB; D6W6H7; -.
DR STRING; 7070.D6W6H7; -.
DR MEROPS; S01.156; -.
DR EnsemblMetazoa; TC004654_001; TC004654_001; TC004654.
DR HOGENOM; CLU_003273_0_0_1; -.
DR InParanoid; D6W6H7; -.
DR OMA; CNMLVEC; -.
DR Proteomes; UP000007266; Linkage group 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:EFA11570.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 950..1188
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 298..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 716..728
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 723..741
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 735..750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 804..819
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1206..1224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1218..1233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1233 AA; 137576 MW; 8C8C0189E27A4DF9 CRC64;
MPVCNRRSTP SVHTLWQERM SPRSCTERKS RGRLCSVALA IASFLVFVAV LSIAGMALYM
GALHTEPPSS NNIISFSCSA KILRGDRFTG ALQEKARRYR LQLETLYQRS VLGPALTSCI
VEKFGNDTVT VFFKLAFNKK KISKNVSNLE KTIRDILITD AISRKPVFRM IRFDPKSIEI
KQIRDVDTYQ RSATKPKDTK NKTSVVLKTP RKNTTLTTTL PVKKKTDEIE IKEEDLPVVQ
GSFKISKTDA DITEKKTENV STPKPKITTQ ATKTTTIKET SVTSALYKIA AIEKLSKTST
GTPSTSTTTK NPLFSNPQVF NEQPWIPIIP DLTPITVPTT KPPQIPPKQP IYTSFTNPSL
SYHNIDMEPL GSTSLKGHPI PVNKIPQVTE PSVFETSKKP TENSGFVEIE TVKYVPGSSG
DKMKQQNMLK NLSSIFHDLA STLKIPEMNV SKNETFLGVA DEDSVGEGQV EVVEADEETL
MMQTTKLPLV TLIPVKSNSG IGRPLRKRPF RNEENSTGDV SVENRSFPGS TRLNDFSALE
KNPLKFIETE VVTSVSSEVN KVKLNKNQLE DFKIVGVLNF ATEASDTSEE LLRNPKMDPQ
SNRTEVLRKH EPSSEITVYA TNSSVSSNRK EANFNILTPE KLKQLSEISK IHDNLTVIDK
EPVISNKAIS SSYTVNHSGF KILTKTFNKI DELPKDTKLN GYNNLAFTAI SNKTECGNLT
IKCGDGQCLP ETTKCNQLID CNDGKDEQDC NCADYLRSQY LLRKICDGVV DCWDYSDENQ
CEWCEPQQYV CSNSKMCIDK TKICDGLRDC PQGDDERQCV TIAENIDAAD EFPYTSEGLL
MVRKFGSWGK LCVENLRNLV FPILDLGKAV CKSMTYQFLD SVKSVTETDE RTPSRYFEMD
YTFENSSKYS LSFSETGCET RKVVRVRCQA LECGARPQAV KHIARRAYRI VGGGNAGLGS
WPWQAALYKE GEFQCGATLL SDTWLVSAGH CFYHSQDEHW VARLGALRRG TALPSPYEQL
RPITRIIVHP GYVDSGFIND ISLLKMEFPV IFSDYVRPIC LPPPGQMVPD GRLCTVVGWG
QLFEVGRIFP DTLQEVLVPV ISTAECRKRT VFLPLYKITD DMFCAGYERG GRDACLGDSG
GPLMCPEPDG KWLLQGITSN GYGCARANRP GVYTKVANYV TWIEAHMSRD DHNSTKKKSV
CLGHRCPLGE CLPKSRLCNG YIECSDGSDE RDC
//