ID D6W9D4_TRICA Unreviewed; 5178 AA.
AC D6W9D4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEZ98177.2};
GN Name=AUGUSTUS-3.0.2_00606 {ECO:0000313|EMBL:EEZ98177.2};
GN ORFNames=TcasGA2_TC000606 {ECO:0000313|EMBL:EEZ98177.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EEZ98177.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EEZ98177.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ98177.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EEZ98177.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ98177.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KQ971312; EEZ98177.2; -; Genomic_DNA.
DR STRING; 7070.D6W9D4; -.
DR EnsemblMetazoa; TC000606_001; TC000606_001; TC000606.
DR eggNOG; KOG0383; Eukaryota.
DR eggNOG; KOG4443; Eukaryota.
DR HOGENOM; CLU_000051_0_0_1; -.
DR OMA; LQYEQWL; -.
DR Proteomes; UP000007266; Linkage group 2.
DR GO; GO:0044666; C:MLL3/4 complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd15665; ePHD1_KMT2C_like; 1.
DR CDD; cd15666; ePHD2_KMT2C_like; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15510; PHD2_KMT2C_like; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15514; PHD6_KMT2C_like; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 7.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00249; PHD; 8.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 5.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 250..357
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 366..416
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 413..463
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 703..756
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 753..803
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 830..885
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 4659..4767
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 5038..5154
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 5162..5178
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1091
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1512..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1691..1804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1871..1891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2001..2026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2111..2130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2250..2300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2315..2401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2523..2701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2818..2932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2986..3020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3224..3248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3446..3520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3800..3820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3910..3936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4031..4182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4967..5005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2444..2478
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1452..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1486
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1512..1535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1536..1559
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1691..1730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1740..1759
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2114..2130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2267..2292
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2320..2343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2358..2390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2523..2541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2551..2623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2626..2640
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2864..2901
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2918..2932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3230..3248
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3446..3509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3805..3820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4031..4046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4061..4082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4094..4150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4984..5005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5178 AA; 573548 MW; 705D36918B045CEC CRC64;
MEELGQALDP DDLMDLDEGS DLDEEEDELD DPLPSPFQFP SSGATSAASS PPNDDFPLPF
GFSGKPLSVK RGRGRPRREG DRHDPETLSL LTGLLTGKPA QRRPPKIKKL KGCAPRRKFK
PFEFDFNSIA PSPSDEMSLD PETGALIFEK EKPAPVFEEL PYFPEQWPGK VCAFCNLGER
SQLGQGEMLR LLCPEGFTPQ RVAQDQGDSG SSNLPTPERE TGDKSPRGPV TCRRQKSFNK
CRHPSLTSEY VDELTIIGYT EEPHVSTLFD SSGYFYTHRS CAQWSHGVTK NENSALENVG
PAVLQSSSRK CSFCNHYGAS ILCKIEGCTK VYHFPCATAS GAFQVLNLLA LFCSNHIGQA
SLECENSVCY TCKTLGDIAN LMFCSSCGEH YHGICVGLAQ LPGVRAGWQC RKCRICQVCR
MTGDETKLMT CEQCDKIYHS TCQRPIVTSI PKYGWKCRCC RVCGDCGSRT PGAGLSSRWH
AHYTVCDSCY QQRNKGFSCP LCHRAYRAHA HREMVQCTLC RKFVHGTCDP EADLVTYHQR
KEAHPEYEYV CLMCKNLTQP ATLLAKRNSI DDPTDCVAPP PESPFDENAE FDNPFPVDVI
RNMGLGKGKP YSASKIAKKR LGLGSTRPKG VGKNIPGKVG FMKRQRLTDF GRKRGAKSKM
RGVFGVPGVG LQRPVSDGKN DEEPGVENRL VLCSAKDKFV LTQDICVMCG ALGTDHEGCL
ISCVQCGQCY HPYCVNVKIT KVVLQKGWRC LDCTVCEGCG QRNDEARLIL CDDCDISYHI
YCMDPPLDYV PHGNWKCKWC AICQTCGATD PGFNCSWMNS CSECGPCASH VNCPSCSEPY
SEGDLIIQCV QCERWLHGTC DSIKTEEDAE KCAEEGYNCL LCRPRDVPPP HLIPCGTALK
PPTPTKSPEV KSNNNYYVDG VYLSEAGFSL IKSLSLEQHS TRKKRKKIAT VQDKEAGIMA
TIESVVAGGS SDNFPEDSAK LELVDVKDEP QEIYKEGMIW MKDDGPPPDG FTLFTMENGV
SVLRRKRQRN LQKLGIGGFL VRMRGIRSGQ DNDDIDVLPG QSNPSGSDLS MGMPVDVEKP
RRKPVRRKPK SKLAETFPSY LQEAFFGKEL LDSTKELYSS SSDEEKNSSD VDKTIQLTQD
EIKAVAAVTP KNDRVEAKNV LEKKVVPKEE EEENTEDLKD VLAIPGDLLD TDIVNTIMNE
GDGEFNKNGE SLDALTATNL PDESDITNTL ASASTSKDTK DELSDILGPN FTLESMPNIN
GKDVEDIFKG VLTDDSQESQ ESNVFPIQNN NTFSASNSQT IAQHPVNPPP VRPTALPTVN
QSNMNSPLSF PPRSPYQSEY SNSPQFSPAF SEPPSPWVAV NDSGDLDAPS AAAQSTYNQR
SSEKMKADEG LGNGATISAV LYANINCPEW KTEFPNWSDR YKQILKKWRT LTPDQKAPYL
QQARDNRSAL RMKKQQQSQM SKDASVPPTT PTSKAPTVPP PPAAAPTVVA TTNTMISSTQ
VPAIVSPSVS EVCTQQQQQQ SRPTPSLTTA STSSVSVSPP PPPTQPPTTP RPPPLTPSPT
TQQQFTVHGQ FLGPGDHCGP APNVTVNPLY QPNVVNEQNP TLPIIRNNVQ STPPATDQQI
RVLTPSEIMR TLPSLCQENY EPQPLDQEKV ALQHKSAREA EQERQWKQLQ ALRQQQAQQQ
QNVIHEQRVQ SMARVQRQIS DPSPFPQDQT TPELSPVTSP SPNPRQLLTM GIKSPTFPHP
VQTPMRPPPP TPPTPLEFTP EAGDPYAKPP STPKLPQPSF QTRLPADPYA VQPSTPRPQF
QIRPNLQGLN AATVRNESPE LSRQLRDLLQ RQQFKKLDDQ IMAGKGQQRV WPPVEQSQEE
TTPVVVTSAG DTTFRQPLPP SIARPRLPLP VGGIRQPGPH LGLRMQLDPR IQGLDPRMRL
LIQQQRLIQQ NTAPGQQQQP QQQQQQLFSG GTVRFAPGIV RPTSVEQYEL LQRQQQATFQ
PRATEPQMAP RLPIGQMIQR PPISQTPAVP TSGTTSSENQ SNDQEIPDNV TAELEKLEQE
TGTMPELQGV DILGGLGDDD DELLAEMGAD FNILEYADPE ALPGEKTNIL DLELEEEPIK
NDKKVKVELP KVSTGKPTPS SQQIKKDVTP PVTSVITASP ALPNTNVHPP PLAISQAQTA
HPLPAGITSH LTPQQIHQQM LHQVQQAAAL GKPMPLGAKL QSPDGIIGIV MPNNLVHLQI
PQGYQQRLLV SQLQNQKLQM RLGQNVPRMM SPATTLHTNP VALNPGPRMN VPAPPPPPYP
GPPPPYPGTA PPPQQQQQQE QPLLLEDLLE QEKRELEKQN QNQTGGTQEV APSSSANVEQ
ESTLLTDHDF DRITDVLGSP TMNINPNARQ NQVVSNPAQV QQWSQNQNRP KPTPTPTPQP
TTEIRVQTFN ANVIPPPPLP PENIVTEQDK QKQLVYEQWL SHQSNTLNQQ LKYYETEMNK
LRKLRKSLNS KQRQLRKTGG QLADADANEL QKIAAEQAVL QKYLDSSRKQ SRQHGLLLQE
YRNKQQAKQS GPGQSPLLMQ QNPSPLGPPS SSPIHHSQSP MMSPSASPLA QHSPLHSPSP
MISHSPGPGS VTNILQSPSG MSPMQPSPRI GTPHSQGDSS PGPAPSPGQI CLPPPAPRMT
SPQHKRVVTS PVGYSGDLRP GTPQMRFVRT PMDQRRLPSP MMYQQKPGTP SPLSSPPPQQ
MTMNQQLIQK IEGQEANILT SQRAAQLIQQ RNFVRQQLQQ QQQLQQQQQQ QQQLQQQQQQ
QAVAQPQPLT PQQHQMMVQQ QQQLAKQQQQ QIAKQQQQQI AQIQAQLQQK FQQQQQQQQQ
QQQQQQQNVA PPSPMPPKSP MINQQIMSPH SMPPSPMPPR SPMMNFNSNP QTPNSPATRN
NYHMNQPPSS PMMTHNQYQP PSSPMPRSPM MGMRRPPSAN SSPMQDRPRS VERTFTNQGT
LDNMLDQGGG GGNPNNNPIP APPGFGRFGY FKLGLRGGSP MWSFGRGAKR IPTPPGTNKD
DKTNVGESSM PVKPRKESHL SKVSILKRKS PAKTNLQSLA VSKVGSLVST DYNEFDDSSC
TPPVTPPPTT SRIKTVGKKI SEVTDSKDVM IVHSPDAKQM NEIMDYDDDN NTVISGEVSL
SSAAQQNDAD DIAVIETFSQ SDLGEAMSSP LESDQIGDEY LLFPGNMVVD LSGDGETHYS
DKEEAEEEDY GGEKMHVVIR SPTTSDDEYI MQNKGKKYNI RGIETADSPE QEEMQADPSP
EGDEEEESEI VIIDPSIKSP DEQISTKEDF EELIDEGSRK EKIMKPEMVT AKHINEIHKY
TNVYSFPPKS EAVSGANTSR VASLITSKLG QKFSLITTPV VTVSKVDTQN KTVGTTPTSK
VTNIILHSAV RSNVLNVPKL VTSGSSAITI VSANTSPIAS ILPSGFTVPV ISASAVRQLP
NVKVIDKPSS SISLTTHDTC LPKKIFEDDS VSPDSSNCED DKSKDSSDEK SKIDSPPIEE
KAKTPPVTKE ESPKPANESE VEKVHTTSVK VQEQRTSSPV IAKTSSPVII HNTPELKMTA
QVIQESQSGI QITATETVDG FEGTSDDTKS VVISIPSPTP SQEQMLDNIA LQALENRRRD
GNGMPGEFES FEDVLDMIEN ITGEPPTVLE DNIKDKLMSG DNKSVTIEQE QLKETPQTTQ
VETPQITKPS VVPQLSPLSQ PTDLTTNMAN ASQQLRNLLS LHTTTATPST NVETVVKSVV
TTGPVLTASP VVTPRVIQQV TTSTVIVPNM KPKPIVLQSP VRTQTTTVAA TTSIQITTSG
ITFVPRSTGI QLMPEHPKLP RVTPVVTSTP VTTESETTTR KTTCSLTEML QSHPAAVPTT
KTSADTITAA SLLGTSIGLS RVSTSLVQAQ PIVVSPATCN NLVVTTTSGF KPITTNTNLL
HTQLTKVMRH KSLDETNEES KTETEPNLDD KNKQETGCKF SSIQTTIAAT TRSEDSNALL
KKLLQNTACA STQTPPPSSV AAASITVAAP IQFTSTLESQ LKASILPPVV KETPKLTQKM
PIMTRETSFV SSPVVPQTST TQQLHIDIKK CMPPSRTPSR DDLLSPPTPR SSCSQDSSLQ
TPPLIVKKEM PQHLQMSQDV KKEYVDETSQ HSEVSDQSRS DVPMKEELDS LDPMTEKMLS
EKEELKRQKR RMYQQKRRQN QILNKEAIGQ PKKRPRKSSK VDEDYDTYID GVLAQLRTLP
PMVVSEPILN RNFSICPVFG SDMVKLAAND YDSRFGELKG SYGNGCMPGY SDFYNTQPYG
DREPLPEKPP ASTQRGFYDQ EFPLIKFDTE EEKRFDMFSR DDTPDSIISS SSPECPFTEP
PHKFLGLKLI NEDEDEEEED MSKMRLSPVV PIIAPIPIRL KPAGPYLKDY TEDKENVGRD
VCLKPKFGSG STTPLKDSGN VTVTLTLTSS AAEDIMGVLR DLANILHIPA PTSYQIVERT
STPPSQKLGL YRTKGKDGKE GAPIDIQSIL NGAAKFCKHC DVVILNNMIR KKVSELPFLS
KDSELLSDGD ELFFCSTTCY MQFALMHRSP SIPEDKAAAI IDHLCQKDKT EANKRSFSDH
RKNFMDNVEM ELQYVKREVD AMDVDLKSHS LFNKPTDIIS LRRYEQNTPK VWKGVRYKSW
TPGCLQPPTK HKKPTDKETM ELLYRMGITV TPPKLPEDFR KCMFCQCIGD GVADGPGRLL
NFDVDKWVHL NCGLWSDGVY ETVNGALMNL ENALQQSLTQ ICVHCNKLGA TIRCFKTRCS
NVYHLACAVK DGAVFYKNKT TYCTVHIPKN EKDNELTTLS VSRRVYVNRD ENRQVAAVMH
HSDTNNLLRV GSLIFLNVGQ LLPHQLQNFH NQNYIYPIGY KIIRFYWSMR HLNKRCKYIC
SIHENGGRPE FKVVVQETLE NDVELKDSTP KAVWQRILEQ IAAMRRENQC VQLFPQFVSG
EDLFGLTEPA VVRVLESLPG IETLTDYKFK YGRNPLLELP LAINPSGAAR TEPRSRSQLH
WKRPHTQRTG GSSVRPLFGP TPALTNNNTL GDGACPYTKQ FVHSKSSQYK KMKQEWRNNV
YLARSKIQGL GLYAARDLEK HTMVIEYIGE IIRTELAETR EKKYEAKNRG IYMFRLDEER
VVDATLCGGL ARYINHSCNP NCVAETVEVD RDYRIIIFAK RRIQRGEELA YDYKFDIEDD
QHKISCMCGA PNCRKWMN
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