ID D6WCY3_TRICA Unreviewed; 550 AA.
AC D6WCY3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=Acyloxyacyl hydrolase-like Protein {ECO:0000313|EMBL:EEZ98824.2};
GN Name=AUGUSTUS-3.0.2_04431 {ECO:0000313|EMBL:EEZ98824.2};
GN ORFNames=TcasGA2_TC004431 {ECO:0000313|EMBL:EEZ98824.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EEZ98824.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EEZ98824.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ98824.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EEZ98824.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EEZ98824.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971311; EEZ98824.2; -; Genomic_DNA.
DR RefSeq; XP_969018.2; XM_963925.3.
DR AlphaFoldDB; D6WCY3; -.
DR EnsemblMetazoa; TC004431_001; TC004431_001; TC004431.
DR GeneID; 657467; -.
DR KEGG; tca:657467; -.
DR eggNOG; ENOG502QVQW; Eukaryota.
DR HOGENOM; CLU_025769_0_0_1; -.
DR OMA; PFCHLYP; -.
DR OrthoDB; 4166at2759; -.
DR Proteomes; UP000007266; Linkage group 2.
DR GO; GO:0050528; F:acyloxyacyl hydrolase activity; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0009104; P:lipopolysaccharide catabolic process; IBA:GO_Central.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IBA:GO_Central.
DR CDD; cd01826; acyloxyacyl_hydrolase_like; 1.
DR Gene3D; 1.10.225.10; Saposin-like; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR039676; AOAH.
DR InterPro; IPR048593; AOAH_Saposin_N.
DR InterPro; IPR001087; GDSL.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB_dom.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR15010; ACYLOXYACYL HYDROLASE; 1.
DR PANTHER; PTHR15010:SF0; ACYLOXYACYL HYDROLASE; 1.
DR Pfam; PF00657; Lipase_GDSL; 1.
DR Pfam; PF20825; Saposin; 1.
DR SMART; SM00741; SapB; 1.
DR SUPFAM; SSF47862; Saposin; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS50015; SAP_B; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000313|EMBL:EEZ98824.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..550
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007310640"
FT DOMAIN 24..102
FT /note="Saposin B-type"
FT /evidence="ECO:0000259|PROSITE:PS50015"
SQ SEQUENCE 550 AA; 63130 MW; 40CCEE5825916DF9 CRC64;
MKTFQVFLFL LFCTSFTNAR GVNGGMSCAV CTVLTGVTMQ IAELHEEDLF NATKRLCNVL
PNKIRHPCFR IVDKVEPYLT NLSEKITPDL FCLVYGTCRV DKGQPFCHLF PLTMEQEEME
NVLKKEREKM LPKIDFCKLP YIKDICNILN NSYTSLAPVE DFDNDGFSAM ETGRGSDWRG
RDCVDNDPQV YPGRRPLNSD YFSDSNCNGI WGTKNDTFLS LEQELCKKSQ PRGLIFIGDS
IGAHFHMPEV WINPLLFSWP GLNGSSVILD EIDWPQFGFA TGFKNITRNI LIQGLTDSLY
LRLRNRNRCN HRDYQNLSQN GASSYEGLNH VNSIARNRTT DNPALVIYAM QGNDVCNNFN
DTINHMTSPE TFRRNVMKSL FLLDEKLPPQ SHVVLVELVE ADFIFPAMAE RLHPIGRLHK
NVFYKNLYEW FNCMQIGPCT GWLNANQTLR DITSKRARKL STILKYIATN ETFKNFQVHY
IQNPINYLVR NDKINITEFL EPVDSLHPNQ KAQVLLTETV WNFLEKLPVL GPVNPHNDEI
IRIFGEQGGH
//
