ID D6WKA3_TRICA Unreviewed; 1712 AA.
AC D6WKA3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0000259|PROSITE:PS50067};
GN Name=AUGUSTUS-3.0.2_14111 {ECO:0000313|EMBL:EFA03966.2};
GN ORFNames=TcasGA2_TC014111 {ECO:0000313|EMBL:EFA03966.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA03966.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA03966.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03966.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA03966.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA03966.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; KQ971342; EFA03966.2; -; Genomic_DNA.
DR STRING; 7070.D6WKA3; -.
DR EnsemblMetazoa; TC014111_001; TC014111_001; TC014111.
DR eggNOG; KOG0242; Eukaryota.
DR HOGENOM; CLU_241739_0_0_1; -.
DR InParanoid; D6WKA3; -.
DR OMA; YEQHETL; -.
DR Proteomes; UP000007266; Linkage group 5.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF36; CENTROMERE-ASSOCIATED PROTEIN E; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000007266}.
FT DOMAIN 4..324
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT COILED 347..381
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 493..545
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 608..649
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 689..1233
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1263..1371
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1482..1512
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1586..1620
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1681..1708
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 87..94
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1712 AA; 201399 MW; D88C8B054EB03161 CRC64;
MSTNIQVAIR IRPLIASEEA KKLQVQWGTQ KNNIFQIDDN GQKFGDVFSF DHIFGVDKTN
TDIYDNIVKD FVESSLNGLN STIFAYGQTS SGKTYTMLGD KKHRGIMSLA IENIFEHIEN
STDRKFLIRV SYIEIYNEKI YDLLDPSNKE VKIREFFPAT IGLQNIKEEI VTSRKQMYEC
LRTGTLNRHI AGTKANDRSS RSHTIFKITI ESTQVSDFTS GPVQVSSLNL VDLAGSERVA
QTKATGVRLK EGSHINKSLS ALGLVIRQLS DGQEFINFRD SKLTRLLQDS LGGNSKTLII
ATITLASIED TCSTLAFAQR AKAVKNKPHV NEILTDADLS KRYASLNSQL QKKLEEQLRI
NQKLQETQEV NVREMSRLQQ QMELIEHFQR GKISEIPSIP KRRHTIGFAT PMPLSSIVFK
PDCDTSNQDP HSLLFLDEFS SKDHTALGNT LETIVEEDFI TPMKRNLEKQ RRSSYSSVCS
EFPVEDNDAL KKITELEEEI YNEKQKQQEC EIQLKELNDK FKLREEDLCN KILELEKKLE
NENSDNFYST IIGFKDQLLY LQQILSNEKI ETEFSNSYSE KDLTNKSYSL ELSEVKECDE
LHLELMDKEQ EERKCLSILE ENEKLKMELI HYETKNKFLT DELDRLTTEI KQKHTLKNSN
EMELTLDEYE LKQDYIKLKN EFTASCTENE FLQKSNEEMK RKIEKYDSLK QEYIQLKNDL
TTSRTENDSL LKLIEEMKGR IEEYHSLNIQ LQNKLKMNRK TEEYDSLSQQ YIQLKNELTS
SSTEKEFLLK SNEEMRRRIE EYELLEQQYI QFKNEFTTLC TENDALQNSV EEMKRGIEEY
QSLKSEYIQL QDEFNAFCSE KESLKKSNEE MKKRTEEYEL LKQQYIQLKN EFNASCTEKD
SLQKLNEEIK RIVEENESLK QEYIQLNNKF NASCTEKDSL QKSNEEMKRK IEENESLKEE
YVQLKNEFSA TCREKESLQK LNEEIKRRIE ESESLKQEYI QLKNKFDASC TEKDSLQKSN
EEMKRKIEEN ESLKEEYVQL KNEFSTTCRE KESLHKLNEE IKRKIEESES LKQEYIQLKN
KFNASCTEKD SLLKSNEEMK RKIEENESLK QEYAQLKNEL SASCREKESL QKLIEESKRE
VEESESLKQE HIQLKIKFND LCAEKDSWQK SNEEMKRKIE ENESLKEEYI QLKNEFSATC
REKESLHKLN EKIKRKIEES ESLKQEYIEF KNKFTALCTE KDSLLKLEYA QLKNEFKVSC
TEKDSLKKSN EEMRMIIEEQ KKKIENMKIC NDKLNLEIRN KETNSKEQLC TMSSQNNYLK
NELEKLKNEV ADQKRIISAN KEKLHCNDLE LQKQKRRLLE GEEHVKELEY KIRQSSEKES
NFRTIIEAQN VTIDKLNLKY RNILGSIMEY FISEQKSLLL IRHSQDEREN FKSIIRDLKT
NNATLKSQVE QLRNENNCDL CAIQETIKKS HLIFKDYFSL EKTFLKAQII DLENTNEEYL
KEMMALKDQQ RNDSTEDCSN CDKLQNEITR LTEVATSQDK LVVTLEKENS TLRKERFESV
KQVVHLQQQI FDEQDKKSEL QYTEWMKFLQ DNNKLQQQEI RELKRKIKKY ENMHSRSVNK
QSVGTECNLL GAPATEIDKS KNVRVEDVQN GCLHFSGKIS TIHAEVQCNI FSEPSALQEK
YDLLKQIYRK KNNEIQSLNA EINQLKLKVS SL
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