ID D6WLS2_TRICA Unreviewed; 1071 AA.
AC D6WLS2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Leucine-rich repeat protein soc-2 homolog {ECO:0000256|ARBA:ARBA00023904};
DE AltName: Full=Protein soc-2 homolog {ECO:0000256|ARBA:ARBA00032455};
DE AltName: Full=protein Sur-8 homolog {ECO:0000256|ARBA:ARBA00029588, ECO:0000256|ARBA:ARBA00029998};
GN Name=AUGUSTUS-3.0.2_30752 {ECO:0000313|EMBL:EFA04777.2};
GN ORFNames=TcasGA2_TC030752 {ECO:0000313|EMBL:EFA04777.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA04777.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA04777.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA04777.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA04777.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA04777.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- FUNCTION: Acts as a Ras effector and participates in MAPK pathway
CC activation. Probably acts as a regulatory subunit of protein
CC phosphatase that specifically dephosphorylates Raf kinase and stimulate
CC Raf activity at specialized signaling complexes upon Ras activation.
CC {ECO:0000256|ARBA:ARBA00025612}.
CC -!- SIMILARITY: Belongs to the SHOC2 family.
CC {ECO:0000256|ARBA:ARBA00023786}.
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DR EMBL; KQ971343; EFA04777.2; -; Genomic_DNA.
DR AlphaFoldDB; D6WLS2; -.
DR STRING; 7070.D6WLS2; -.
DR EnsemblMetazoa; TC030752_001; TC030752_001; TC030752.
DR HOGENOM; CLU_005692_0_0_1; -.
DR InParanoid; D6WLS2; -.
DR OMA; QFKVCQT; -.
DR Proteomes; UP000007266; Linkage group 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF1; ZGC:77287; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00481; PP2C; 1.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00332; PP2Cc; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS51746; PPM_2; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 571..795
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
SQ SEQUENCE 1071 AA; 121349 MW; B6A5C16504D7EEA7 CRC64;
MLCASKKPFR LCDSVTKFPQ IKENDSNIEL DSLENCERDG DDDIEDKDQV KQLNLNGLCK
NKQELSECYV DEIVLPGESL QSLSDLKVLS LRSNGIQNFP NSILQLVTLV TLDLSDNSLL
TLPPEISLLE NLSELVLDQN LLSVLPTTLW DLKFLQTLKV ARNRLALPPD KPGEMRALIL
AESELKPENH NKNGLTTLNL RSNRLKGNII LGNYGNLTEL DVSENSIENL DLSAVEQLQI
LQCSRNSITH LTLHGKNLTS IIAGNNRLRN LTLAHPPLNL RHLDVCYNEL ETLPDWLSGC
SELRSLFASN NLLTSLPDHL FCNEMPFLHT LQIAYNQLQY LPTIQRRLPI QELFLQNNSL
SSLPENFFRF VHPIRVLNLS NNRLCDLPTP EEPLQLEKLF LTANCLIDKS LEKISPYLRN
IRILHAAYNS FTSLPEDCST YWTEIEELVF SGNKLLKLPE RIGCLKHLSV LRVHSNLLQS
IPKLSNLLCL RVLDLAHNQL DRIDLTALIP PNLKFLDLSC NTKLHVDSQQ FNTYRTQRPM
SLVDVSGKNR TTLPLTPSPF CENDLTEYSW SVGFSETAGC KQRLYISQIR LPAFCNTEGL
FGMFDGETNN NVPVGVDKVV PRILLEERTV KETASDYMKY TMLSAHRELK DKGQKQGLNA
IICHILRTKQ AVKYSFCAST KKYLMKIASV GDIRVVLGRA TGPVRLLPVK QRKQIRTNPQ
IQLMVPDPDV TEIFLDEQDE FMIMANKNLW DVMTPENAIR EVALQRNVIL AAKRLQDLAQ
SYGAEDNLSI IVVKFNLLGT DVDLLMRELR QTIRRNKYQS DSTNSCQPGC CCEALSNECA
NCEKIPIPPP MILNDDRSSP SGQSEQACSD CNSSAKLFVN QLNRSARSIT PSIFEAAEVK
ASPERRSYRG VAKALRARRE EEKNQNDSDS ALSEEQFKCW EYMLEQNTQL LFDKELNTLT
RSIRKPQFTI KNPTLSRSNP HLSDSNNNGT FLSKQFGSTR SFNPLLTRSG SKFALDKKLM
GGPHAAYFGS LQRLMPYNLE YDFAVMHERG LADSLDLDRM QQYWGVTTTE L
//
