ID D6WRB4_TRICA Unreviewed; 1466 AA.
AC D6WRB4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like Protein {ECO:0000313|EMBL:EFA07479.2};
GN Name=AUGUSTUS-3.0.2_09361 {ECO:0000313|EMBL:EFA07479.2};
GN ORFNames=TcasGA2_TC009361 {ECO:0000313|EMBL:EFA07479.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA07479.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA07479.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA07479.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA07479.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA07479.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; KQ971351; EFA07479.2; -; Genomic_DNA.
DR RefSeq; XP_015836734.1; XM_015981248.1.
DR STRING; 7070.D6WRB4; -.
DR EnsemblMetazoa; TC009361_001; TC009361_001; TC009361.
DR GeneID; 660611; -.
DR eggNOG; KOG4297; Eukaryota.
DR HOGENOM; CLU_002791_0_0_1; -.
DR InParanoid; D6WRB4; -.
DR OMA; DHHDNNT; -.
DR OrthoDB; 3035244at2759; -.
DR Proteomes; UP000007266; Linkage group 7.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00033; CCP; 12.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 16.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR008197; WAP_dom.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF567; LOCOMOTION-RELATED PROTEIN HIKARU GENKI; 1.
DR Pfam; PF00084; Sushi; 13.
DR Pfam; PF00095; WAP; 1.
DR SMART; SM00032; CCP; 17.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 15.
DR PROSITE; PS50923; SUSHI; 14.
DR PROSITE; PS51390; WAP; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1466
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007310827"
FT DOMAIN 59..112
FT /note="WAP"
FT /evidence="ECO:0000259|PROSITE:PS51390"
FT DOMAIN 113..170
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 172..236
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 237..295
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 296..353
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 354..413
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 479..536
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 537..608
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 721..787
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 803..864
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 963..1029
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1223..1280
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1281..1340
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1341..1397
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1399..1458
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 23..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 141..168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 324..351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 384..411
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 835..862
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1000..1027
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1251..1278
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1311..1338
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1370..1397
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1429..1456
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1466 AA; 162499 MW; F5F9BB9F70C64330 CRC64;
MHKVWSWLIL GIAVSQVLSL RLERSPSPST TPTPDDDDDE WDDDDSSEIE DDGKIYKNPR
NSPSTLCPRD DAQATQLGHR CLRKCSSDED CKSKKKKCLC DGACGMSCIK PDRECPEPKQ
IPFGSVSYTE RVFGSKATYS CQHGYHVVGL QSRTCQADGK WAGSAPVCKQ NIYCLSPPTI
DHARHNALPE QTTFDLDSTL QYYCHTGYVT NGFPRAKCLA IDGQASWYGP DISCEPNSCG
APTDISHGWH AGECYTYGCR ITYHCAEGYE LVGKNERFCQ ADGTWTPKEL PTCVPVQCSP
PENPRHGKAI YTSCSYNSVV SYECKYGYTL QGESSRRCGA DRKWSGAQPI CKEINCGHPG
RLWNGWLENI EGGTGLGASI IFRCHEGMLL VGNTSTVCQS DGKWRYPLPK CLAPCVVPHV
SQGRVILVSK NDTAPTSTVV QHGEALEVNC EYQYEFLAST SAVTCNNGTW THIPKCEPAR
CKHLPKPPKN GMVIAPKMNH NMKARFKCKD GFQIKGHPLI ECSFGNWTGE IPKCEEVYCP
YPGSVSNGKI LLVGNMGLYD YRPYVRKVTN NKQIMYDCDK GYVLAEGPPG ATCIGGIWSP
SQLPKCILGQ HPRLRWNRRR RSIVMEKYKR AFIRQNKLIY QNREKRHVHN YLNYLKEQHR
EGAKMRLKRA LKGGSSSRAF GTSHKSSNSQ LSLRRGNKKN YNYYEEEKQE EIKKPKHKSR
GPCEPLSSEP YVNIEIVKHG RDHNVSFSSG TIVKMACGKG YGLNMPENKT AKCVRGRWRP
TKPTCSILPC FVPSIENGVF KLSKAELPSN ITFDLDEPLN ETVEIGNGQV VEFSCLEGYN
IQGPSNLRCW HGDWTVTGLP ECTASPCQLP QITNGQYLMG YRAGLTIANG SSVTFQCDSD
YSKSTAQPIQ CILGELYPKS PSCRPEAGVD LNSKVIDSPH FIGGADIIKG GDITVLQYGS
PSKACGPPAK VQGSLVYKNG EPIVDDENNF PDGTEVTFNC IETIMGEKTT WKIVCEDGSW
IGRSLNCDTE ELLASQIVYN NNTCIFRNQE PNVISFYNDQ QIREEVVEFP AGAVLVSRCV
DIGKYAMTGS NTRRCMGGDW DGTKPACFGL NQENDYSMEK PPTILFRHQL GPIAQSNDGK
LIVYPGTILH MECLWIRRFG NPKWTVSHDY RKYPEGWTTD PGRDSQLEYR LSIFHASKDD
SGLFTCVTPA RYTHSVEIEV KAVHCPIVPQ RRGLTVNTQS TKMNTRLKFS CINGNALIGA
SEITCLPSGN WSAPFPVCES IECGEVGGVL PSRLRVLVVS REVGGRAVFS CEPGFGLRGP
QETVCQPNGD WATPFPTCEE VQCDNPGSPE NGYMQGSGPF KAGDVVQFNC NPDFMMEGQP
IIACQDNSRW SGKLPKCVQA CSYPGTTISG KMSSVKFYYK IGENITFTCD EGLTLKGAAM
LKCLKNGKWS NAIPTCVTEN NTPEND
//
