ID D6WUE3_TRICA Unreviewed; 870 AA.
AC D6WUE3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Multiple C2 and transmembrane domain-containing protein 1-like Protein {ECO:0000313|EMBL:EFA07297.2};
GN Name=AUGUSTUS-3.0.2_14537 {ECO:0000313|EMBL:EFA07297.2};
GN ORFNames=TcasGA2_TC014537 {ECO:0000313|EMBL:EFA07297.2};
OS Tribolium castaneum (Red flour beetle).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA07297.2, ECO:0000313|Proteomes:UP000007266};
RN [1] {ECO:0000313|EMBL:EFA07297.2, ECO:0000313|Proteomes:UP000007266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA07297.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=18362917; DOI=10.1038/nature06784;
RG Tribolium Genome Sequencing Consortium;
RA Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G., Friedrich M.,
RA Grimmelikhuijzen C.J., Klingler M., Lorenzen M., Richards S., Roth S.,
RA Schroder R., Tautz D., Zdobnov E.M., Muzny D., Gibbs R.A., Weinstock G.M.,
RA Attaway T., Bell S., Buhay C.J., Chandrabose M.N., Chavez D.,
RA Clerk-Blankenburg K.P., Cree A., Dao M., Davis C., Chacko J., Dinh H.,
RA Dugan-Rocha S., Fowler G., Garner T.T., Garnes J., Gnirke A., Hawes A.,
RA Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V.,
RA Khan Z.M., Jackson L., Kovar C., Kowis A., Lee S., Lewis L.R., Margolis J.,
RA Morgan M., Nazareth L.V., Nguyen N., Okwuonu G., Parker D., Richards S.,
RA Ruiz S.J., Santibanez J., Savard J., Scherer S.E., Schneider B.,
RA Sodergren E., Tautz D., Vattahil S., Villasana D., White C.S., Wright R.,
RA Park Y., Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J., Brown S.J.,
RA Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H., Lorenzen M., Maselli V.,
RA Osanai M., Park Y., Robertson H.M., Tu Z., Wang J.J., Wang S., Richards S.,
RA Song H., Zhang L., Sodergren E., Werner D., Stanke M., Morgenstern B.,
RA Solovyev V., Kosarev P., Brown G., Chen H.C., Ermolaeva O., Hlavina W.,
RA Kapustin Y., Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P., Aranda M.,
RA Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F., Bopp D.,
RA Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E., Ferrier D.E.,
RA Friedrich M., Gordon C.M., Jindra M., Klingler M., Lan Q., Lattorff H.M.,
RA Laudet V., von Levetsow C., Liu Z., Lutz R., Lynch J.A., da Fonseca R.N.,
RA Posnien N., Reuter R., Roth S., Savard J., Schinko J.B., Schmitt C.,
RA Schoppmeier M., Schroder R., Shippy T.D., Simonnet F., Marques-Souza H.,
RA Tautz D., Tomoyasu Y., Trauner J., Van der Zee M., Vervoort M.,
RA Wittkopp N., Wimmer E.A., Yang X., Jones A.K., Sattelle D.B., Ebert P.R.,
RA Nelson D., Scott J.G., Beeman R.W., Muthukrishnan S., Kramer K.J.,
RA Arakane Y., Beeman R.W., Zhu Q., Hogenkamp D., Dixit R., Oppert B.,
RA Jiang H., Zou Z., Marshall J., Elpidina E., Vinokurov K., Oppert C.,
RA Zou Z., Evans J., Lu Z., Zhao P., Sumathipala N., Altincicek B.,
RA Vilcinskas A., Williams M., Hultmark D., Hetru C., Jiang H.,
RA Grimmelikhuijzen C.J., Hauser F., Cazzamali G., Williamson M., Park Y.,
RA Li B., Tanaka Y., Predel R., Neupert S., Schachtner J., Verleyen P.,
RA Raible F., Bork P., Friedrich M., Walden K.K., Robertson H.M., Angeli S.,
RA Foret S., Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT "The genome of the model beetle and pest Tribolium castaneum.";
RL Nature 452:949-955(2008).
RN [2] {ECO:0000313|EMBL:EFA07297.2, ECO:0000313|Proteomes:UP000007266}
RP GENOME REANNOTATION.
RC STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA07297.2,
RC ECO:0000313|Proteomes:UP000007266};
RX PubMed=19820115; DOI=10.1093/nar/gkp807;
RA Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT "BeetleBase in 2010: revisions to provide comprehensive genomic information
RT for Tribolium castaneum.";
RL Nucleic Acids Res. 38:D437-D442(2010).
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DR EMBL; KQ971352; EFA07297.2; -; Genomic_DNA.
DR RefSeq; XP_008193821.1; XM_008195599.2.
DR AlphaFoldDB; D6WUE3; -.
DR EnsemblMetazoa; TC014537_001; TC014537_001; TC014537.
DR GeneID; 661885; -.
DR HOGENOM; CLU_011170_2_0_1; -.
DR OrthoDB; 880291at2759; -.
DR Proteomes; UP000007266; Linkage group 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd04042; C2A_MCTP_PRT; 1.
DR CDD; cd08376; C2B_MCTP_PRT; 1.
DR CDD; cd08377; C2C_MCTP_PRT; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010482; Peroxin.
DR PANTHER; PTHR45911; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45911:SF4; MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06398; Pex24p; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00239; C2; 3.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR PROSITE; PS50004; C2; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:EFA07297.2};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 782..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..283
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 318..435
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 469..592
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 23..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 100000 MW; 3A6740B96B2CF0E1 CRC64;
MIPSKHCDSP SKRALETCEF NNMSSTPTIG ARHLSKSTSE LSSPREMPEI RPRSAAPPEV
SHLSVYQKAH SFFAQLKSRW GHSKRERRHK SPGRQDSTDY AADLSSDHST PSTQSPRHRL
HARTDSPLSR ACPGGGGDTS SPSGSPKPRV PTSSAVAGLD LLPLGSNDEI TRRREAVLRQ
HSFFQLRIHL RRGNGLVAMD KNGLSDPYVK FKVGGRLIYK SRTVYRDLNP TWDESFTVPI
EDPFIPIQIK VFDYDWGLQD DFMGSATLDL TTLDLGRATE VTMVLQDPDR PDTTLGEILL
TATLYPKSQE DKEQYYQKNS RVADVNKRLK SQIWSSVVTI ALVEGKNLLA CDPETGTSDP
YVKFRLGNEK YKSRIVWRSL NPRWLEQFDL HLYDDGDQQL EITVWDKDRS RDDFIGRCVI
DLTTLERERT HSLWQQLEDG AGSLHLLLTI SGTTASETIS DLTTYEENPR EVENIMNRYI
WHRTFHNMKD VGHLTVKVYR ASGLAAADLG GKSDPFCVLE LGNARLQTQT EYKTLSPSWQ
KIFTFNVKDI NNVLDITVFD EDRDHKVEFL GRVLIPLLRI RNGEKRWYAL KDRKLRSRAK
GNNPQILLEM NLAWNPIRAC IRTLNPKEEK YMQSEVKFKR QVFVRNVLRL KVFIMYFYEF
GKIFQNCFEW ESKVQSFAAL LLFLVLCYYF EPWMLPIAGL LIFLKQYIVR ILAGPSLIPW
DETADSDIED DEDDDKEKEE KKSLKERLQA IQEVTQGVQN AIGRIASLLE AVKNTFNFTV
PYLSWIAIGL LVAATIVLYL IPIRYLLMLW GTNKFFRRIL RPHSVPNNEV LDLLSRVPDD
EMLLDYKDLK ILINPEAERR RDPKKKHKAS
//