ID D6YB70_THEBD Unreviewed; 409 AA.
AC D6YB70;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN OrderedLocusNames=Tbis_1717 {ECO:0000313|EMBL:ADG88430.1};
OS Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM
OS 10125 / KCTC 9307 / NBRC 14880 / R51).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Thermobispora.
OX NCBI_TaxID=469371 {ECO:0000313|EMBL:ADG88430.1, ECO:0000313|Proteomes:UP000006640};
RN [1] {ECO:0000313|EMBL:ADG88430.1, ECO:0000313|Proteomes:UP000006640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / KCTC 9307 /
RC NBRC 14880 / R51 {ECO:0000313|Proteomes:UP000006640};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Mikhailova N., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F.,
RA Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA Wu D., Jando M., Schneider S., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Thermobispora bispora DSM 43833.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
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DR EMBL; CP001874; ADG88430.1; -; Genomic_DNA.
DR RefSeq; WP_013131963.1; NC_014165.1.
DR AlphaFoldDB; D6YB70; -.
DR STRING; 469371.Tbis_1717; -.
DR KEGG; tbi:Tbis_1717; -.
DR eggNOG; COG1169; Bacteria.
DR HOGENOM; CLU_006493_8_5_11; -.
DR OrthoDB; 9806579at2; -.
DR Proteomes; UP000006640; Chromosome.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000006640}.
FT DOMAIN 151..399
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 409 AA; 43454 MW; B55599BAC04FECE3 CRC64;
MRVSIALIRP LVVRTVAVTD PRDLLAHLPG TAPYAWIRRG EGLVGWGVAA RAEVPPGPGR
FDWAREWLAS LFEGARIDDQ VGLPGSGPVA FGSFTFDRDV PGSVLVVPRV VLARRQGQAW
LTTIGEAETL PVAPATEPGR IRYGDGTLSA PEWQHVVAQA VAKIKAGVLD KVVLARDLRA
TAEREIDPRA LLARLADRYP ECYTFSVDGL VGATPELLVR HIGRSIESLV LAGTVSRGTG
PAEDAARAAE LYASAKDREE HGYAVASVRQ ALAPLCAELH VPDEPDLLVL PNVQHLATRI
TGRLSDGASV LDVVAAMHPT AAVGGTPTDA AIEVIRELEG MDRGRYAGPV GWIDSRGDGE
WGIALRCAEV SGREARLFAG CGIMGGSDPA AELAEAQAKF RVMQYALEG
//
