ID D6ZAW7_SEGRD Unreviewed; 738 AA.
AC D6ZAW7;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=MMPL domain protein {ECO:0000313|EMBL:ADG98853.1};
GN OrderedLocusNames=Srot_2409 {ECO:0000313|EMBL:ADG98853.1};
OS Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM
OS 44985 / JCM 13578).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Segniliparaceae;
OC Segniliparus.
OX NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG98853.1, ECO:0000313|Proteomes:UP000002247};
RN [1] {ECO:0000313|EMBL:ADG98853.1, ECO:0000313|Proteomes:UP000002247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC {ECO:0000313|Proteomes:UP000002247};
RX PubMed=21304703; DOI=10.4056/sigs.791633;
RA Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M., Schneider S.,
RA Bruce D., Goodwin L., Pitluck S., Liolios K., Mikhailova N., Pati A.,
RA Ivanova N., Mavromatis K., Chen A., Palaniappan K., Chertkov O., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Detter J.C., Han C.,
RA Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT 1076).";
RL Stand. Genomic Sci. 2:203-211(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001958; ADG98853.1; -; Genomic_DNA.
DR RefSeq; WP_013139303.1; NC_014168.1.
DR AlphaFoldDB; D6ZAW7; -.
DR STRING; 640132.Srot_2409; -.
DR KEGG; srt:Srot_2409; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_5_1_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000002247; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002247};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..738
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039613764"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..346
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 407..722
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 738 AA; 77777 MW; 96E9BA5EDCEC9CBF CRC64;
MLRHVSRLAI RAPRRVLLAA AVCTMAAAGY GATVAEHLSA AGFQDPGSQS VRGAELLAEK
FGQGDADLTF VVRSPDGVFA PQAAAQAREL VSTVRHAPHV ASVLDPWGLA PAEANAMVSA
DGKAALILAR VSGGESEAQK HAKEVSDKVA GEHGALTVRA GGMSMVLSEI NEQSERDLVS
AEAVAVPLTF LVLMWVFGGL YAALLPLVVG LLSIAATLGA LRLFTVFADV SVFALNLTTA
MGFALAIDYT LLLVSRYREE HERTKDRAAA LRRAVDTAGR TVAFSACTVF LAVGALGVFP
MYFLRSMAYA GCAVVALAAL YAVVVAPAMI MLLGDRIDGL DVRRLLRRKS RNPAPAAESG
PQGGVLYRTT RFVMRHAATC ALAATAALLL LGSAFTRAQF GLPDDRVLPA TAQSRQVGDA
LRAEFPQNAA VPVSIVIPDA SGIAAQEVSG YADELSKVPG VAVVDAPDGS HVRGGLAGPS
GAAAGTKDAS VWLTAVLRAP AFTEQSRAAL ADVRAVPRPK GVEVLFTGTE QLNEDTVAAI
MRQLPFVFGF VAVTTFLLLF LLTGSILLPL KALVLNTLSL SATLGALVWI FQEGHVGGFG
TTTTGTLVSD MLVFLFTVAF GLSMDYEVFL LSRIREFWLA SARRAEDNAE AVALGVSRAG
RVVTAAALLM FVVFVSLITS EVSFMRMFGL GLAVAVAVDA TLVRMVLLPA FMRLAGTWNW
WLPEPLARLH RRVGLREG
//
