ID D6ZBC8_SEGRD Unreviewed; 1164 AA.
AC D6ZBC8;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Phenyloxazoline synthase MbtB {ECO:0000256|ARBA:ARBA00016743};
DE AltName: Full=Mycobactin synthetase protein B {ECO:0000256|ARBA:ARBA00033440};
GN OrderedLocusNames=Srot_2436 {ECO:0000313|EMBL:ADG98880.1};
OS Segniliparus rotundus (strain ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM
OS 44985 / JCM 13578).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Segniliparaceae;
OC Segniliparus.
OX NCBI_TaxID=640132 {ECO:0000313|EMBL:ADG98880.1, ECO:0000313|Proteomes:UP000002247};
RN [1] {ECO:0000313|EMBL:ADG98880.1, ECO:0000313|Proteomes:UP000002247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-972 / CDC 1076 / CIP 108378 / DSM 44985 / JCM 13578
RC {ECO:0000313|Proteomes:UP000002247};
RX PubMed=21304703; DOI=10.4056/sigs.791633;
RA Sikorski J., Lapidus A., Copeland A., Misra M., Glavina Del Rio T.,
RA Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Jando M., Schneider S.,
RA Bruce D., Goodwin L., Pitluck S., Liolios K., Mikhailova N., Pati A.,
RA Ivanova N., Mavromatis K., Chen A., Palaniappan K., Chertkov O., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Detter J.C., Han C.,
RA Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Segniliparus rotundus type strain (CDC
RT 1076).";
RL Stand. Genomic Sci. 2:203-211(2010).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005102}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC MbtB subfamily. {ECO:0000256|ARBA:ARBA00007380}.
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DR EMBL; CP001958; ADG98880.1; -; Genomic_DNA.
DR AlphaFoldDB; D6ZBC8; -.
DR STRING; 640132.Srot_2436; -.
DR KEGG; srt:Srot_2436; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_2_4_11; -.
DR OrthoDB; 2472181at2; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000002247; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd19535; Cyc_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF10; PHENYLOXAZOLINE SYNTHASE MBTB; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002247}.
FT DOMAIN 2..78
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1067..1142
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1164 AA; 124735 MW; 93B92FBDE838C41A CRC64;
MSEPVISLEK IRHQVAGVLA VPPDSLATDA DLISLGLDSI RMMSLAGAWR KQGVDVAFGA
LAAAPTLAGW HALLQNAPKK PSPAVRSSAA PVQAGELASA GKVFPLAAMQ HAQWVGRDGG
QRLGGVAAHL YVEFDGAHVD PARLKAAVDL LVQRHPMLRV QILPEGAQRV LPAAGGQVFA
HEDLGALAEH DAQERLELIR EQKSHQHLAV HEGQVFDVLL VSLPDGRSRL CLDVDMIAAD
AMSYRVLVAD LAALYRGERL EPLSITFQEH LERKRAVADS REETDRAWWA ERLAALPPPP
ELPVLPEAES GLAHSPRATR RHYWLSPQRK QALFERCRSR GVTPAMALAS IFATAIGNWS
ANPKFLLNLP LFTRDAADSR LDRVVGDFTS SVMLSVDLAE PQTVGERACS LQQSFHEAAA
HSAYSGLNVL RDLSRLHGEQ ILAPVVYTSA IGLGELFAQG VAETFGKPVH VLSQGPQVAL
DAQVTEIDGG LLLNWDVREP LLRPGVVEAM FAWYTAEIER LATDPEQWAA LSGQGALPAR
QREVREALRA SAPASDTQRA LHTGFFENAE RNPGAVAVIA EDGSVTTYAE LRRQALAVAG
ALAELGVRRG EAVAVALAKG AAQIPVLLGV LASGGVYVPV GVDQPQARRQ QIARTARIAA
VIAPDDVAAA SVEAWAGTVP AVSATSATEH PRPLPEPVAV TADDLAYVLF TSGSTGEPKG
VELRHGAPMN TIAAVVDRFG ITETDRCLSL SPLECDWSVF DIFGMFSVGG SVVVIEEASR
QEPALWAQLM RTHEVTYIGW MPGWLDLLLD ASSGDLPSLR VALAGGDWVS ADLPRRLRVR
APQTRFAGLG GATETAIHST VFEVPNEEGS PPAHWRAIPF GRPLAGVRCR VVNPRGEDCP
DWVPGEYWVG GAGIAEGYRG DPERTEQRFV QYQGERWYRT GDLVRCWPDG VLEFVGRMDH
RIKVRGYGVE LGEVETALRR IPGVARAVVV PLEGVTTRLV GAVSVEAGAD LDANSVRAAL
GCALPAHMVP DTVVLLEAMP LTAVGKLDRA AVRKLVETAA QAQEGVSPRT SLEAALVRIL
GEVVGGEIGV LDDFFSFGVD SILAIKAVSQ IRDWLDSPQA AVADFFAART VAGLAERLQA
KEAEPGRLEK VAEVYLEVAA MPMP
//
