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Database: UniProt
Entry: D6ZZ11_STAND
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ID   D6ZZ11_STAND            Unreviewed;       548 AA.
AC   D6ZZ11;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   28-FEB-2018, entry version 42.
DE   SubName: Full=Thiamine pyrophosphate protein TPP binding domain protein {ECO:0000313|EMBL:ADH91130.1};
GN   OrderedLocusNames=Snov_3860 {ECO:0000313|EMBL:ADH91130.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 /
OS   NBRC 12443 / NCIB 9113).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH91130.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCIB
RC   9113 {ECO:0000313|Proteomes:UP000006633};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Beatson S., Kappler U.,
RA   Woyke T.;
RT   "Complete sequence of Starkeya novella DSM 506.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
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DR   EMBL; CP002026; ADH91130.1; -; Genomic_DNA.
DR   RefSeq; WP_013168631.1; NC_014217.1.
DR   STRING; 639283.Snov_3860; -.
DR   EnsemblBacteria; ADH91130; ADH91130; Snov_3860.
DR   KEGG; sno:Snov_3860; -.
DR   eggNOG; ENOG4107RA9; Bacteria.
DR   eggNOG; COG3961; LUCA.
DR   HOGENOM; HOG000061334; -.
DR   KO; K04103; -.
DR   OMA; EWIGNCN; -.
DR   OrthoDB; POG091H0FS6; -.
DR   BioCyc; SNOV639283:G1GLM-3872-MONOMER; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR012110; TPP_enzyme.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   PIRSF; PIRSF036565; Pyruvt_ip_decrb; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006633};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR036565-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR036565-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006633};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        4    174       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      196    320       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      379    522       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
FT   METAL       457    457       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR036565-2}.
FT   METAL       459    459       Magnesium; via carbonyl oxygen.
FT                                {ECO:0000256|PIRSR:PIRSR036565-2}.
SQ   SEQUENCE   548 AA;  58094 MW;  FFFBA24EF749A4A5 CRC64;
     MALTVIQHVL SRLQDIGIAD VFGVPGDFAF PVNDAICRQP GMRWIGCANE LNAAYAADGY
     ARIKGVGALS TTYGVGELSA LAGVAGAYAE RLPIFHLVGM PRMAVQRARA IVHHTLGTGE
     YELFRRMSEP VVCAHAVMTP QNVAYETERL IAEALYHLRP VYMAFPADLA NQPVVSAAAP
     VPAPQSDPTQ LAAATQAVVA ALEGVETACV LPGLLVARLG IGDRLQALID ASGLPFATMF
     HDKTVLDEQQ PAYAGMYDGA LMNEEVQAFV EDAERIVTVG TLMTDFNTGG FTSNLDHGRT
     IAIDHHSVSV DGRTYPSVEL GDVLASLAQA LPKRDWPRLV PGSLGPVTGA GDEPITAEAL
     YPRWAEFIRP GDIVVAETGT ASMGLGFARM PSGANFYNQA LWGAIGWATP AALGTAVADP
     SRRTVLITGE GSHQLTVQEL GTFGMLGLKP VVFVLNNDGY LIERLLCKDP EISYNDVAPW
     RYAELPRALG CDGWTVARAA TCAEFDAALT AAEGANSGAY VEVVTGRYEA SPLSLKLSEK
     LKQAAAEG
//
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