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Database: UniProt
Entry: D7A7U2_STAND
LinkDB: D7A7U2_STAND
Original site: D7A7U2_STAND 
ID   D7A7U2_STAND            Unreviewed;       833 AA.
AC   D7A7U2;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   OrderedLocusNames=Snov_3125 {ECO:0000313|EMBL:ADH90400.1};
OS   Starkeya novella (strain ATCC 8093 / DSM 506 / JCM 20403 / CCM 1077 / IAM
OS   12100 / NBRC 12443 / NCIMB 10456).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Xanthobacteraceae; Starkeya.
OX   NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH90400.1, ECO:0000313|Proteomes:UP000006633};
RN   [1] {ECO:0000313|EMBL:ADH90400.1, ECO:0000313|Proteomes:UP000006633}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8093 / DSM 506 / JCM 20403 / CCM 1077 / IAM 12100 / NBRC
RC   12443 / NCIMB 10456 {ECO:0000313|Proteomes:UP000006633};
RX   PubMed=23450099; DOI=10.4056/sigs.3006378;
RA   Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A., Copeland A.,
RA   Berry K.W., Glavina Del Rio T., Hammon N., Dalin E., Tice H., Pitluck S.,
RA   Richardson P., Bruce D., Goodwin L.A., Han C., Tapia R., Detter J.C.,
RA   Chang Y.J., Jeffries C.D., Land M., Hauser L., Kyrpides N.C., Goker M.,
RA   Ivanova N., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of the facultatively chemolithoautotrophic and
RT   methylotrophic alpha Proteobacterium Starkeya novella type strain (ATCC
RT   8093(T)).";
RL   Stand. Genomic Sci. 7:44-58(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP002026; ADH90400.1; -; Genomic_DNA.
DR   AlphaFoldDB; D7A7U2; -.
DR   STRING; 639283.Snov_3125; -.
DR   KEGG; sno:Snov_3125; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_004585_5_5_5; -.
DR   OMA; YQDTNRT; -.
DR   Proteomes; UP000006633; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW   ECO:0000313|EMBL:ADH90400.1};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          69..350
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          351..618
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         90..97
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   833 AA;  91784 MW;  1BF8B5C3539182B9 CRC64;
     MTASGPLADP RKQPRDDEFD IPFDLPATAP AGAPAPAPIP APRPGGIAAR AQALANPGRG
     EPSRGVYLDG LNPEQREAVE ATDGPVLVLA GAGTGKTRVL TTRIAHILSL GLAWPSQILA
     VTFTNKAARE MKERIHAMVG EEVEGMPWLG TFHSIGVRML RRHAELVGLK SGFTILDTDD
     QIRLLKQLLR AENIDEKRWP ARLLANIIDG WKNRGLSPQQ VPAGEGAAFA NGRGQKLYTD
     YQARLKALNA VDFGDLLLEG IRLLRENPDV LADYHRRFRY ILVDEYQDTN VAQYLWLRLL
     AQGSRNVCCV GDDDQSIYGW RGAEVDNILR FESDFPGAKV VRLERNYRST GHILGAAAHL
     IAHNEGRLGK TLFSEGENGE KVTVTGAWDS QEEARAIGEE IEALQREGHA LTQVAILVRA
     SFQMREFEDR FVTLGLNYRV IGGPRFYERA EIRDALAYLR VIASPADDLA FERIVNVPKR
     GLGDAALRQI HDHARAAQLP LIEAARELVG SEELKPKVRL TLRDLVASFD RWREQMATLP
     HHELAEIVLD ESGYTEMWQK DRSADAAGRL ENLKELVRSM EPFENLIGFL EHISLVMDVD
     SGNGGDAVNI MTLHSAKGLE FDTVFLPGWE EGVFPNQRAL DEQGRAGLEE ERRLAYVGIT
     RARRRAKVFF ASNRRIHGLW QSAVPSRFLD ELSEKDVEVT ESRGGSGWGG GQGGGYAGRY
     GYGPSRFDQA ETFGSSYSTP GWQRAQNAAK SGSGFSEGRS RYAASESARG GRIIEGELIA
     KSTGAPSRFA IGDRVFHQKF GYGEVSSVEG NKLTVQFDKA GEKKVVDSFV DAA
//
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