ID D7A7U2_STAND Unreviewed; 833 AA.
AC D7A7U2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN OrderedLocusNames=Snov_3125 {ECO:0000313|EMBL:ADH90400.1};
OS Starkeya novella (strain ATCC 8093 / DSM 506 / JCM 20403 / CCM 1077 / IAM
OS 12100 / NBRC 12443 / NCIMB 10456).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Xanthobacteraceae; Starkeya.
OX NCBI_TaxID=639283 {ECO:0000313|EMBL:ADH90400.1, ECO:0000313|Proteomes:UP000006633};
RN [1] {ECO:0000313|EMBL:ADH90400.1, ECO:0000313|Proteomes:UP000006633}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8093 / DSM 506 / JCM 20403 / CCM 1077 / IAM 12100 / NBRC
RC 12443 / NCIMB 10456 {ECO:0000313|Proteomes:UP000006633};
RX PubMed=23450099; DOI=10.4056/sigs.3006378;
RA Kappler U., Davenport K., Beatson S., Lucas S., Lapidus A., Copeland A.,
RA Berry K.W., Glavina Del Rio T., Hammon N., Dalin E., Tice H., Pitluck S.,
RA Richardson P., Bruce D., Goodwin L.A., Han C., Tapia R., Detter J.C.,
RA Chang Y.J., Jeffries C.D., Land M., Hauser L., Kyrpides N.C., Goker M.,
RA Ivanova N., Klenk H.P., Woyke T.;
RT "Complete genome sequence of the facultatively chemolithoautotrophic and
RT methylotrophic alpha Proteobacterium Starkeya novella type strain (ATCC
RT 8093(T)).";
RL Stand. Genomic Sci. 7:44-58(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP002026; ADH90400.1; -; Genomic_DNA.
DR AlphaFoldDB; D7A7U2; -.
DR STRING; 639283.Snov_3125; -.
DR KEGG; sno:Snov_3125; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_5_5; -.
DR OMA; YQDTNRT; -.
DR Proteomes; UP000006633; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560,
KW ECO:0000313|EMBL:ADH90400.1};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 69..350
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 351..618
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 90..97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 833 AA; 91784 MW; 1BF8B5C3539182B9 CRC64;
MTASGPLADP RKQPRDDEFD IPFDLPATAP AGAPAPAPIP APRPGGIAAR AQALANPGRG
EPSRGVYLDG LNPEQREAVE ATDGPVLVLA GAGTGKTRVL TTRIAHILSL GLAWPSQILA
VTFTNKAARE MKERIHAMVG EEVEGMPWLG TFHSIGVRML RRHAELVGLK SGFTILDTDD
QIRLLKQLLR AENIDEKRWP ARLLANIIDG WKNRGLSPQQ VPAGEGAAFA NGRGQKLYTD
YQARLKALNA VDFGDLLLEG IRLLRENPDV LADYHRRFRY ILVDEYQDTN VAQYLWLRLL
AQGSRNVCCV GDDDQSIYGW RGAEVDNILR FESDFPGAKV VRLERNYRST GHILGAAAHL
IAHNEGRLGK TLFSEGENGE KVTVTGAWDS QEEARAIGEE IEALQREGHA LTQVAILVRA
SFQMREFEDR FVTLGLNYRV IGGPRFYERA EIRDALAYLR VIASPADDLA FERIVNVPKR
GLGDAALRQI HDHARAAQLP LIEAARELVG SEELKPKVRL TLRDLVASFD RWREQMATLP
HHELAEIVLD ESGYTEMWQK DRSADAAGRL ENLKELVRSM EPFENLIGFL EHISLVMDVD
SGNGGDAVNI MTLHSAKGLE FDTVFLPGWE EGVFPNQRAL DEQGRAGLEE ERRLAYVGIT
RARRRAKVFF ASNRRIHGLW QSAVPSRFLD ELSEKDVEVT ESRGGSGWGG GQGGGYAGRY
GYGPSRFDQA ETFGSSYSTP GWQRAQNAAK SGSGFSEGRS RYAASESARG GRIIEGELIA
KSTGAPSRFA IGDRVFHQKF GYGEVSSVEG NKLTVQFDKA GEKKVVDSFV DAA
//