ID D7B319_NOCDD Unreviewed; 828 AA.
AC D7B319;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN OrderedLocusNames=Ndas_3303 {ECO:0000313|EMBL:ADH68709.1};
OS Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115 / JCM
OS 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509)
OS (Actinomadura dassonvillei).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=446468 {ECO:0000313|EMBL:ADH68709.1, ECO:0000313|Proteomes:UP000002219};
RN [1] {ECO:0000313|EMBL:ADH68709.1, ECO:0000313|Proteomes:UP000002219}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 /
RC NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509
RC {ECO:0000313|Proteomes:UP000002219};
RX PubMed=21304737; DOI=10.4056/sigs.1363462;
RA Sun H., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H., Cheng J.F.,
RA Tapia R., Han C., Goodwin L., Pitluck S., Pagani I., Ivanova N.,
RA Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K., Land M.,
RA Hauser L., Chang Y.J., Jeffries C.D., Djao O.D., Rohde M., Sikorski J.,
RA Goker M., Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU
RT 509).";
RL Stand. Genomic Sci. 3:325-336(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
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DR EMBL; CP002040; ADH68709.1; -; Genomic_DNA.
DR RefSeq; WP_013154316.1; NC_014210.1.
DR AlphaFoldDB; D7B319; -.
DR STRING; 446468.Ndas_3303; -.
DR KEGG; nda:Ndas_3303; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_6_1_11; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000002219; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 3.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ADH68709.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002219};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 19..474
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 784..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 446..473
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 786..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 89884 MW; 6C8213BB1D0C8CB1 CRC64;
MARTTSRPPE DLAEKIIDID VSEEMRGSFL EYAYSVIYQR ALPDARDGMK PVQRRILYQM
NEMGLRHDRG HVKCARVVGD VMGRLHPHGD TAIYDALVRL SQPFAMRVPL VDGHGNFGSL
GGDDAPAAMR YTEARLDRAA EQLVASIDEN VVDFRPNYDG QETEPEVLPA AFPNLLVNGA
SGIAVGMATN MAPHNLGEVV AAARHLIAHP EATLEELTEF VPGPDLPTGG TIVGLDGIRD
AYRSGRGTFK TRATVSIEKV SARRTGLVVT ELPYSVGPEK VISRIKELVQ SKKLQGISDL
KDLTDRTQGL RLVIELKNGF NPEAVLEELY RLTPMEESFG INNVALVDGQ PQTLGLRELL
EVYVNHRLDV VRRRSEFRRA KRQERLHLVD GLLVALLDID RVISLIREAE DTAAARESLM
GAYDLSEIQA RYILETPLRR LTRFDRMELE TERDKLNKEV DALTAVLESD KKLRRLVSKE
MGDVAKEFAT PRRTQLRESD GVARSAVIPL EMADQPCHVL MGVHGAIGRS KGPSVPRVYE
GLRTRHDAVH VSVPTTSRSA VGLVTDLGRM IRVPVVELPE LPDEGGDSPP LASGLDVSEF
VQLDGDERVV SVVSMDASGP GFALGTRGGV VKRVSPDYPP NKDDFEVVAL KDDDRVVGVT
QLSTGEEDLA FITSEAQLLR FSASAVRPQG RPAGGVAGVR LSEGARVLWF GAVPSPQDSV
VVTVSGSSGA LEGTQAGSAK VTPFEAYPVK GRATGGVRCH RYLKGEDTLL FGWIGRSPAR
AARADGKPVR LPDPIDRRDG SGDALPRAIV TVGSGQTDSG ITVPGAKA
//
