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Database: UniProt
Entry: D7BG28_MEISD
LinkDB: D7BG28_MEISD
Original site: D7BG28_MEISD 
ID   D7BG28_MEISD            Unreviewed;       439 AA.
AC   D7BG28;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   23-MAY-2018, entry version 56.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Mesil_0001 {ECO:0000313|EMBL:ADH61949.1};
OS   Meiothermus silvanus (strain ATCC 700542 / DSM 9946 / VI-R2) (Thermus
OS   silvanus).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae;
OC   Meiothermus.
OX   NCBI_TaxID=526227 {ECO:0000313|EMBL:ADH61949.1, ECO:0000313|Proteomes:UP000001916};
RN   [1] {ECO:0000313|EMBL:ADH61949.1, ECO:0000313|Proteomes:UP000001916}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700542 / DSM 9946 / VI-R2
RC   {ECO:0000313|Proteomes:UP000001916};
RX   PubMed=21304690;
RA   Sikorski J., Tindall B.J., Lowry S., Lucas S., Nolan M., Copeland A.,
RA   Glavina Del Rio T., Tice H., Cheng J.F., Han C., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA   Goodwin L., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.D., Rohde M., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Meiothermus silvanus type strain (VI-
RT   R2).";
RL   Stand. Genomic Sci. 3:37-46(2010).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP002042; ADH61949.1; -; Genomic_DNA.
DR   ProteinModelPortal; D7BG28; -.
DR   STRING; 526227.Mesil_0001; -.
DR   EnsemblBacteria; ADH61949; ADH61949; Mesil_0001.
DR   KEGG; msv:Mesil_0001; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000001916; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001916};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001916}.
FT   DOMAIN      137    265       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      348    417       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     145    152       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   439 AA;  49949 MW;  321756F1A5D17939 CRC64;
     MSQQTIWQNV LDYVRQNIND VEYHTWFEKI RPLGVHGGVL ELGVPTSFAG EWIKKHYAEL
     IQEALTRLGA QTPRFELKVV PGNPVQEDIF SAPVQAPAPD PRSRLNPKYT FENFVVGQNN
     RLAHAAAMAV AESPGKAYNP LFIYGGVGLG KTHLMHAVGH SVAARFPSLR IEYVSTETFT
     NELINAIRED RMTEFRERYR SVDLLLVDDI QFVAGKERTQ EEFFHTFNAL YEAHKQIILS
     SDRPPKDILT LEARLRSRFE WGLITDIQPP ELETRIAILK MNSEYRSMRI PEEVLEYIAR
     QVTSNIRELE GALMRVIAYA SLNGVEITKN VAARALSDVF TARETDFSPD DILRAVADHY
     GLRTDELKGA GRRKEVVIPR QIAMFLIREL TQSSLPEIGQ FFDGRDHTTV LYAIQKVQEL
     ADSDPSIQQT LRSIKERLG
//
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