ID D7BRE1_STRBB Unreviewed; 5139 AA.
AC D7BRE1;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:ADI05104.1};
GN OrderedLocusNames=SBI_01983 {ECO:0000313|EMBL:ADI05104.1};
OS Streptomyces bingchenggensis (strain BCW-1).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI05104.1, ECO:0000313|Proteomes:UP000000377};
RN [1] {ECO:0000313|EMBL:ADI05104.1, ECO:0000313|Proteomes:UP000000377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCW-1 {ECO:0000313|EMBL:ADI05104.1,
RC ECO:0000313|Proteomes:UP000000377};
RX PubMed=20581206; DOI=10.1128/JB.00596-10;
RA Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA Xiang W.S.;
RT "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT bingchenggensis.";
RL J. Bacteriol. 192:4526-4527(2010).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP002047; ADI05104.1; -; Genomic_DNA.
DR RefSeq; WP_014174583.1; NC_016582.1.
DR STRING; 749414.SBI_01983; -.
DR KEGG; sbh:SBI_01983; -.
DR PATRIC; fig|749414.3.peg.2052; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_8_11; -.
DR Proteomes; UP000000377; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08952; KR_1_SDR_x; 3.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 6.10.140.1830; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 4.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 4.
DR Pfam; PF18369; PKS_DE; 3.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00822; PKS_KR; 4.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 7.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 357..432
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 451..859
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1879..1954
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1974..2398
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3430..3505
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3534..3942
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4968..5043
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5139 AA; 540270 MW; 668FEE42A9C1C2C5 CRC64;
MAGDYLPFDL ADAGLDRTQE MLVELMELFE AGVLHPLPVT AWDVRRARDA FRYMSQAKHT
GKIVLTMPPR WDPEGTVLIT GGTGGLGSRL ARHLAVEWGM KHLLLVSRRG PDAPGAPELR
EELSAHGADV TIAACDVADR DALTALLAGV PAEHPLTAVV HTAAALDDGV IASLTPERLA
TVFGPKADAA WHLHELTRDL DLAAFMTYSS VAGQLGGAGL GSYAAANAFL DALANHRRAE
GLPGQSLLWG PWAQDGGMTS ELTDTDIHRL NAAGMPLLTE EQGVALFDAA ATCDEPVVAP
VRLNLAALRA QGEVPGLLRG LVRTARRTAG GASASESGAA TALTQRLAGL READRLRLLI
DLVRGQAAAV LGHPSPDAVE VRREFRDLGF DSLTAVELRN RLGGATGLRL PATLVFDYPT
PTALAEFLLR ELLGDHGEVI LPTAVTSGLA DDPIVIVGMS CRYPGGVRSP EDLWQLVAEG
RDAIAELPTD RGWRLDAGAG YEGGFLYDAA EFDAGFFGIS PREALAMDPQ QRLLLETAWE
VFERTGIDPA SVRGTDAGVF VGATGFGYLP PQESRGHHMT GQATSVISGR LSYTFGLEGP
AVTVDTACSS SLVAMHLAAQ ALRTGECSLA LAGGVTVMST PIGFGEFSEQ GGMAPDGRCH
SFADSAAGTS WSEGVGLVVL ERLSDAVRNG HEVLAVVRGS AVNQDGASNG LTAPNGPSQQ
RVIRQALANA GLAPVDVDAV EAHGTGTTLG DPIEAQALLA TYGQDRELPL RLGSIKSNMG
HTQVAAGMAG VIKMVMALRN GVLPKTLHVD TPSTHVDWTA GAVELLTEPV EWPETGRPRR
AGVSAFGVSG TNVHTILEQA PPPAELKPDD QEIPAVTPAA LPWVVSAKTA EALHGQAVSL
LSHVEGHPGA MPVDIGHSLV STRSVLEHRA VVVGGDREEL LSGLTALGAD GPAAGVVRGV
ADVEGRSVFV FPGQGSQWAG MGARLMDDSP VFAERLAECA AALAPFIDWS LMDVVRQVDG
APSLERVDVV QPVSWAVMVS LAALWRSSGV EPDAVVGHSQ GEIAAACVAG ALSLEDGARV
VALRSQAIAR RLAGAGGMAS VPLPVAEVEA RLERWAGRVS IAAVNGPRSV VVSGDSEALD
QLVEELTGEE VRIRRIAVDY ASHSAHVEGI HEELLAELAP VAPCTAEVPF FSTVTGDWLD
TTGMDADYWY RNLRQTVGFE PAIRALLTQE HRAFIEVSSH PVLTMAVQET IDATGDHAVT
AGTLRRDEGG LGRFLTSLAE VFVRGVDVAW AGMFADTGAH RVDLPTYAFQ RERYWPDETR
PGAQAAEADT ADAEFWSAVE QEDLESLADW LEIDGGSLGA VLPALSAWRG RRREQSTVDS
WRYRTEWRPL RMSSVPVLTG TWLVVTADGI ADGEVTAALA GHGAQVRRLE LDESCVDRAE
LASRLQGVDG IEDIRGMVSV LAFAEQPSAG YPVLPSGLAL SLALVQALDD IGADAPLWCL
TRGAVSTGRA DRLTSPVQAQ VLGLGRTAAL EHPRRWGGLV DLPAELDQRA AQRLAGALAG
TEGEDGEGEF AIRPSGVFVR RVVRTPADDS APKGRWQPRG TTLITGGTGV LGQYLARWLA
HNGAEDLVLT SRRGMAADGA AELVAELAEL GTTVEVVACD VADRDAVAAM ISRLTDEGRV
IRTAVHVAAY IDLVSLSATD HETFAAIVDA KVAGARHLHE LLDDEQLDAV VYYSSIAGIW
GSGDHGAYGA ANSYLEALAE HRRAHGLRAT SIAWGIWRDD QVRVDPRQIL GSGLRYMQPE
LAHTGLRRAL DDDETLLTIA DIDWDRYYPV YTSVRPSPLF SEVPEVRGIL QRAEDTVATS
ADGEFAARIR GLSAAEGERA LLDLVRAEAA AVLGHGSPDA ISERRAFRDV GFDSLTAVDL
RNRVARATGL TLPSTLVFDY PSPVALVEFL RSRIVGSAVA RPGTPAPTVS TASDEPIAII
GMACRFPGGI GSPEQLWEVV AGGQDIISEF PADRGWDAER LYDPDPDKPG KTYSTRGGFL
HDAAEFDAGF FGISPREALA MDPQQRLLLE TSWEAFERAG IDPASVRGSL TGTFIGSSYQ
DYGFGPHTGS EGAEGYMLTS SVPSVLSGRI SYLFGLEGPA VTLDTACSSS LVALHLACQS
LRNGESTLAL AGGVTVMTTP GSFLAFSRQR GMAADGRCKA FAESADGMSL SEGVGLLLVE
RLSDARRNGH PVLAVVRGSA INQDGASNGL TAPNGPSQQR VIGQALTNAK MTANDIDAVE
AHGTGTTLGD PIEAQALLAT YGQERERPLL LGSVKSNLGH TQLAAGAASV IKMVMAMRYG
VLPKTLHIDE PTSHVDWSSG AVELLTEQAA WPETGHPRRV GISAFGISGT NAHAILEQGP
RPEADDGPVA SPVPARAPGV LPVVLPVVVS GKSEEALRAQ AARVVARVEE EPSGLGLVDL
AYSLATTRSG FERRGVVLAG ARPEAVEGLR AVACGESGVN LVQGVAREDR VVAFLFSGQG
SQRAGMGREL YEACPVFAEA LDEVCAHLDA HLDRPLREVL FAEAGSAEAE LLDETAWTQP
GLFAVEVALF RLVESWGVRP DYVAGHSVGE IAAAHVAGVF SLADACTLVA ARARLMGELP
SGGAMVSLQA TEDEVTPYLG ERVSIAAVNG PRSVVISGEE APVLDIATRF AEEGRKTRRL
RVSHAFHSVL MDGMVAEFGR VARGLSYGAP AMPLVSGLTG EPVTAELVCA PEYWVRQVRE
AVRFADGVRW LDGRGVSAYL EIGPDGVLSA MAQESLPEQS PTATVVASAL RKGAEEERAV
VTALARLYAH GVEVDWSAFF AGTGARRIDL PTYAFQHQRY WPEVLAPAPA ADADLTDADA
DTDFWAVVEG EDLESLASRL EVDGDSLGAV LPALTTWRRR RREQSVVDGW RYRAGWTPLA
DPTPQAQRGS WLVVVPADQQ DDAWVTSVAD ATPTPALRVE ITEPDRAALA DRLREVAAES
GPFAGVLSLL GAYEHAVDGH PGVPAGVALT TTLVQALGDA GIESPLWAAT RGAVSVSRSD
TAPSPAQAAV WGLGRVAALE YPGRWGGLID LPGTLDRPAG RRLAAVLSGA GDEDQIAVRS
SGLFGRRVVP CPAELDVDET GFTATGTVLI TGGTGGLGGH VARWLARCGA EHLVLTSRRG
PDAPGARELC DELTELGARV TLAACDVSDR EALAAVLGGI ADDSPLTGVV HTAGIAQAAA
PLDGASDAET AEVMTAKVVG AANLDSLLGD RDLDFFVLFS SVAATWGSGG QGAYGAANAY
LDALADARTA RGLTATSVAW GAWADGGMAA ADGAQDYLAR RGLILMAPET AIAGLSSALR
NRDVTVAVAD VDWDQFAPAF TLARPSALLR DLPAVRRALT ADITTRYDDE SLTSLRGRLR
AMADDDERLD ALLGVVREQV ALVLGHSGGD AIEADRAFKD LGFDSLTAVE LRNRLATATG
LPLPTTLVFD YPSPAALVDH LRAELLGERT DPGGAALPAA SVVTRPSRVS ILADDPIAIV
GMSCRYPGGV RSPEDLWRLV TEGRDAISPF PADRGWNLDA DTAFEGGFVH DATEFDARFF
GISPREALAM DPQQRLLLES AWEVFERAGI DPAGLRGSDA GVFIGATGGG YVAPEESLGH
MMTGQATSVV SGRLSYTFGL EGPAVTVDTA CSSSLVAMHM AMQALRGGEC SLALAGGVTV
MSSPAGFAEF RQQGGLAQDG RCKSFAEGAD GTGWSEGVGL VVLERLSDAR RHGHEVLAVV
RGSAVNQDGA SNGLTAPNGP SQQRVIRQAL ANAGLAPADV DAVEAHGTGT TLGDPIEAQA
LLATYGRDRE LPLRLGSIKS NIGHTQSASG VAGVIKMVMA MRHGTLPKTL HVDAPSTHVD
WASGAVELLT EAVEWPEHGR PRRAGVSSFG MSGTNAHAIL EQAPEDAVAA ESAEDDTPAL
DAVAVPWVVS ARTAEALRGQ AISLLSHAES HPEATPTDIG HSLLSSRSVL EHRAVVVGGD
REELLSGLRA LGDDDPAAGV VRGVADVEGK SVFVFPGQGS QWAGMGVRLL DESPVFAERL
AECAVALTPF IDWSLMDVLR QVEGAPSLER VDVVQPVSWA VMVSLAAMWR SHGVEPDAVV
GHSQGEIAAA CVAGALSLDD GARVVALRSQ AIARRLAGAG GMASVPLPVA EVEAWLERWD
GRVSIAAVNG PRSVVVSGDQ QALDELIEEL TGEEVRIRRI AVDYASHSAH VEEVHEALLA
ELAPVAPRTA EVPFLSTVTG EWLEGGELDA DYWYRNLRQT VGFEPAVREL LARRHRAFIE
ISAHPVLTVA VQETVDDIDE TAVVAGTLRR DQGGLDRFAL SLAELFVRGV HTGWAGFFTA
TGARRIDLPT YAFQRQRFWP EAAETEPLPG DKEAVDAEFW AAVEQEELES LAARLEVDTD
SLGAVLPALS SWRQQRRERS TVDGWRYRTI WKPVTAEAAA PSGTWLVVVP QGLADDPWVS
ALADAVGADA VRLEVGDAGR AALADRLSSY VTDRVGGADG ADGAEFAGVL SLLALSESAL
PEYPSVPAGV VLTATLMQAL GDAGIEAPVW AVTRGAVSLG HSDRATAPLQ NAVWGLGRVA
ALEYPRSWGG LIDLPADLDD RIIGRFVGTL AARTGEDQVA IRSTGVFGRR MVQAPAEAPD
QPWQPSGTVL ITGGTGALGG HVARWLAGNG AEHLLLTSRR GPDAPGADEL RAELSALGAQ
VTIAACDVAD RDALAALLAT VPAEHPLTGV VHTAGVLDDG LMDGLTPERY EPVFRSKVAS
ALLLDELTRD LDLAVFALFA SSSGALGSRG QANYAAANAV LDALAERRRA DGLAATSVAW
GLWAGAGMAA DTPVEAVSQR AGVLAMDPKL AVMALAQLVT GAEPTAFVSA LVWDRFAPTF
SAVRPSPLLS EIPEARRAMR AVSDEPADGS GESLRERLAR MPEPERVSAV VGLVRKTAAA
VLGYDSADAV ESGVPFRDLG FDSLTAVEFS NRLAAATQLR LKRALVFDYP SPTALSQHLL
EQLLPGGTGG TGGADDAATV GGAGGHGRVL AEIDRLEATL ATATTHRETR LQVRERLSKL
LAQWGDEDLD GGPGGVDEQL LEASDEEVFD FIGKEFGIS
//
