ID D7BWR2_STRBB Unreviewed; 823 AA.
AC D7BWR2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=SBI_00297 {ECO:0000313|EMBL:ADI03418.1};
OS Streptomyces bingchenggensis (strain BCW-1).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI03418.1, ECO:0000313|Proteomes:UP000000377};
RN [1] {ECO:0000313|EMBL:ADI03418.1, ECO:0000313|Proteomes:UP000000377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCW-1 {ECO:0000313|EMBL:ADI03418.1,
RC ECO:0000313|Proteomes:UP000000377};
RX PubMed=20581206; DOI=10.1128/JB.00596-10;
RA Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA Xiang W.S.;
RT "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT bingchenggensis.";
RL J. Bacteriol. 192:4526-4527(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP002047; ADI03418.1; -; Genomic_DNA.
DR RefSeq; WP_014172897.1; NC_016582.1.
DR AlphaFoldDB; D7BWR2; -.
DR STRING; 749414.SBI_00297; -.
DR KEGG; sbh:SBI_00297; -.
DR PATRIC; fig|749414.3.peg.309; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_113_1_11; -.
DR Proteomes; UP000000377; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ADI03418.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 383..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 608..817
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 823 AA; 88004 MW; 90E559C3BFFE3B4C CRC64;
MNDVRPGRLK VYLGAAPGVG KTYRMLDEGR RRASRGADVV VGFVECHGRP RTEAMLDGLE
VVPRAHCDYR GGKFQEMDLA AVLARRPQVA IVDEFAHSNV PGGHNSKRWQ DVEELLAAGV
DVITAVNIQH LASLNDVVEK ITRVPQGETV PDEVVRRAQQ IELVDMEPEG LRRRMAHGNI
YAPEKVDAAL ANYFRPGNLT ALRQLALLWV ADQVDEALQM YRTEHGIGRV WETRERVVVA
LTGGLEGDTL IRRAARIADR SAGGDLLAVH VTRSDGLAVG SSHASLARQR RLVEDLGGSY
HSVVGDDVGT ALVEFARAEH ATQLVLGTSR RGRIERFLGG CGTGETVVGM SGDIDVHMVT
HERAGRGMLL PSRRRTLSLV RRVAGPVAGL VLPVLLTVLL DRARGTFNLT SEALLFLLTV
VGVACIGGVA SAVIASVTAS LLLNYWFIPP IGAFTLDNAD ALVALGVFAI VAATVAGVVD
RSLRLSRRSA RATAEAETMS SLAGTIVRGG ATIPALLERT RETFGMESAD LVHHEQTPDE
EGVTVVPAGP GAFLVLRGRT LPSSGRRVLA AFAAHVGSAV ERTRLAEAAA EIEPVKAADR
MRTALLRAVG HDLRTPLAAG WAAVTSLRSR DVEFSDEDRD ELLATADESL AKLNRLVENL
LDLSRLQAGV LTLDLRATTL EEVLPAALAD IPDVEVRDLE EIPAVMADPP LLERVIANLV
GNAARHSPPG GQVALTASAH AGRVEVRVVD RGPGLPQTGR ERIFEPFQRL GDTDNTTGLG
LGLALSKGLT EAMDGTLVPE DTPGGGLTMV LSLPFAERTV YSR
//
