ID D7C3D4_STRBB Unreviewed; 648 AA.
AC D7C3D4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:ADI10159.1};
DE EC=1.3.5.1 {ECO:0000313|EMBL:ADI10159.1};
GN Name=sdhA {ECO:0000313|EMBL:ADI10159.1};
GN OrderedLocusNames=SBI_07039 {ECO:0000313|EMBL:ADI10159.1};
OS Streptomyces bingchenggensis (strain BCW-1).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI10159.1, ECO:0000313|Proteomes:UP000000377};
RN [1] {ECO:0000313|EMBL:ADI10159.1, ECO:0000313|Proteomes:UP000000377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCW-1 {ECO:0000313|EMBL:ADI10159.1,
RC ECO:0000313|Proteomes:UP000000377};
RX PubMed=20581206; DOI=10.1128/JB.00596-10;
RA Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA Xiang W.S.;
RT "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT bingchenggensis.";
RL J. Bacteriol. 192:4526-4527(2010).
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DR EMBL; CP002047; ADI10159.1; -; Genomic_DNA.
DR RefSeq; WP_014179609.1; NC_016582.1.
DR AlphaFoldDB; D7C3D4; -.
DR STRING; 749414.SBI_07039; -.
DR KEGG; sbh:SBI_07039; -.
DR PATRIC; fig|749414.3.peg.7241; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_7_0_11; -.
DR Proteomes; UP000000377; Chromosome.
DR GO; GO:0102040; F:fumarate reductase (menaquinone); IEA:UniProtKB-EC.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR011280; Succ_DH/Fum_Rdt_flav_su.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01811; sdhA_Bsu; 1.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF53; SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ADI10159.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000377}.
FT DOMAIN 47..452
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 513..647
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 341
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630664-50"
SQ SEQUENCE 648 AA; 71615 MW; E0B5A80CBB3B1BFC CRC64;
MSTYAEYTTG EPISDAKAPD GPIEERWNRR RFEAKLVNPA NRRKHTVIVV GTGLAGGAAG
ATLAEQGYHV VQFCYQDSPR RAHSIAAQGG INAAKNYRND GDSIRRLFYD TVKGGDFRAR
ESNVHRLAEV SVEIIDQCVA QGVPFAREYG GLLDTRSFGG VQVSRTFYAR GQTGQQLLLG
AYQALTRQIA AGNVEMHPRT EMLDLIVIDG RARGIVARDL ISGEVSTYFA DAVVLASGGY
GNVFYLSTNA KNSNATAIWR AHRRGAYFAN PCFTQIHPTC IPRSGDHQSK LTLMSESLRN
DGRIWVPKAK GDTRPPAEIP EDERDYYLER IYPSFGNLVP RDIASRAAKN VCDEGRGVGP
GGQGVYLDFA DAIARMGRKA VSEKYGNLFE MYERITAEDP YQVPMRIYPA IHYTMGGLWV
DYDLQTTVPG LFAIGEANFS DHGANRLGAS ALMQGLADGY FVLPSTINDY LARHPHGEVD
PGHPAVTEAV SEVTDRLARL LANDGDRTPD SFHRELGELL WDECGMARTD TGLRKALDRI
PALREEFWRR IKVPGTGEEL NQSLEKANRV VDYLELAELM CLDALHRAES CGGHFREESQ
TPDGEAARDD ESFSYAGAWE FSGTGSAPVL HREDLVFEYV HPTQRSYA
//
