ID D7C874_STRBB Unreviewed; 847 AA.
AC D7C874;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ADI04235.1};
GN Name=nrps3-1 {ECO:0000313|EMBL:ADI04235.1};
GN OrderedLocusNames=SBI_01114 {ECO:0000313|EMBL:ADI04235.1};
OS Streptomyces bingchenggensis (strain BCW-1).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI04235.1, ECO:0000313|Proteomes:UP000000377};
RN [1] {ECO:0000313|EMBL:ADI04235.1, ECO:0000313|Proteomes:UP000000377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCW-1 {ECO:0000313|EMBL:ADI04235.1,
RC ECO:0000313|Proteomes:UP000000377};
RX PubMed=20581206; DOI=10.1128/JB.00596-10;
RA Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA Xiang W.S.;
RT "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT bingchenggensis.";
RL J. Bacteriol. 192:4526-4527(2010).
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DR EMBL; CP002047; ADI04235.1; -; Genomic_DNA.
DR RefSeq; WP_014173714.1; NC_016582.1.
DR AlphaFoldDB; D7C874; -.
DR STRING; 749414.SBI_01114; -.
DR KEGG; sbh:SBI_01114; -.
DR PATRIC; fig|749414.3.peg.1143; -.
DR eggNOG; COG0110; Bacteria.
DR HOGENOM; CLU_010887_0_0_11; -.
DR Proteomes; UP000000377; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR012728; NRPS_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR NCBIfam; TIGR02353; NRPS_term_dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF14602; Hexapep_2; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 2.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 131..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..103
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 822..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 92078 MW; 6DB07900980FADFA CRC64;
MAEKSAEVLI SEPDEPAIGG RVGVEPAGTD IERKLAEVLA EVISAERVST ADHFFTDLGA
NSLVMAQFCA RVRKRPELPS VSMKDIYRHP TIQSLAAAVA GTTATATAVD SPAPTQVVPP
TRKASARTLD YVLCGTLQLL VFLGYSTVTG LVAARGYEWV ADGSGLVGTY LRSVLFGGIG
FVVLCSFPIA AKWILIGRWK SREFPVWGLT YVRFWIVKAL LHANPMHFFI GNPLYVLYLR
ALGARIGKGV TILSHSIPVC TDLLTVGAGT VIRKDSFFLC YRAHAGHIQT GRVTLGRDVF
IGEKTVLDID TSMGDGAQLG HSSALYRGQA VPDGERRHGS PAQPTQIDHV RVGPARCGTS
RRFRFGLGTL LQLFLLYLPL TVGGVYMLFQ AIPALGERAD AGRAGLASSD FLIDALLMSS
VLFFGFVVVG LVVVCAVPRL LNLFIKPDKV YPLYGFHYAA HRAIAGMTNL KFFTWLFGDS
SYIVHYLRGL GYDLSRVEQT GSNFGTEVRH ETPYLASVGS GTMVADGLSL LNAEFSSTSF
RVSRASIGAH NFLGNNIAYP AGARTGDNCL LATKVMVPLD GELREGVGLL GSPCFEIPRS
VERDSRFDHL RGGEELRRSL AAKNRYNARS MVFFLLVRWL HAFVLTALGL ASICLYGELG
HVVIAGYLAL TLAFTALYFT LVERGVAAFR ALRPRLCSIY DPYFWWHERL WKVPDEHLDL
FNGTPFKNVI WRLLGVRLGS RVFDDGCYMT ERTLTAVGDD CTLNIGSKIQ CHSQEDGTFK
SDRTTLGADC TLGVGTHVHY GVTLGDGVVL APDSFLMKGE EVPPNAQWGG NPAAEMPVAN
HAGSTAM
//
