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Database: UniProt
Entry: D7CFB7_STRBB
LinkDB: D7CFB7_STRBB
Original site: D7CFB7_STRBB 
ID   D7CFB7_STRBB            Unreviewed;      2512 AA.
AC   D7CFB7;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   23-MAY-2018, entry version 57.
DE   SubName: Full=Putative type I polyketide synthase WcbR {ECO:0000313|EMBL:ADI13133.1};
GN   OrderedLocusNames=SBI_10015 {ECO:0000313|EMBL:ADI13133.1};
OS   Streptomyces bingchenggensis (strain BCW-1).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI13133.1, ECO:0000313|Proteomes:UP000000377};
RN   [1] {ECO:0000313|EMBL:ADI13133.1, ECO:0000313|Proteomes:UP000000377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCW-1 {ECO:0000313|EMBL:ADI13133.1,
RC   ECO:0000313|Proteomes:UP000000377};
RX   PubMed=20581206; DOI=10.1128/JB.00596-10;
RA   Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA   Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA   Xiang W.S.;
RT   "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT   bingchenggensis.";
RL   J. Bacteriol. 192:4526-4527(2010).
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DR   EMBL; CP002047; ADI13133.1; -; Genomic_DNA.
DR   RefSeq; WP_014182580.1; NC_016582.1.
DR   ProteinModelPortal; D7CFB7; -.
DR   STRING; 749414.SBI_10015; -.
DR   EnsemblBacteria; ADI13133; ADI13133; SBI_10015.
DR   KEGG; sbh:SBI_10015; -.
DR   PATRIC; fig|749414.3.peg.10313; -.
DR   eggNOG; ENOG4107EEY; Bacteria.
DR   eggNOG; COG3321; LUCA.
DR   HOGENOM; HOG000256642; -.
DR   OMA; AVNCDGK; -.
DR   OrthoDB; POG091H06Z6; -.
DR   BioCyc; SBIN749414:G1GKW-10081-MONOMER; -.
DR   Proteomes; UP000000377; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   Gene3D; 3.40.366.10; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 3.
DR   SUPFAM; SSF52151; SSF52151; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000377};
KW   Phosphopantetheine {ECO:0000256|PROSITE-ProRule:PRU00258};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000377}.
FT   DOMAIN     2428   2503       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   COILED     2420   2440       {ECO:0000256|SAM:Coils}.
FT   MOD_RES    2462   2462       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   2512 AA;  266975 MW;  2773A92F284B34A2 CRC64;
     MNGTDSAGQS IAVVGAALRL PGGISSLNGL WDVLLQGQDM IGPVPGDRFE AARFVDTSMP
     RRGKSYTGVG GFLDDISAFD AAYFGISPKE AAHMDPQHRL LLELTAEALD DAAIDPARLG
     GSDTAVYVGI SDASYGALQM SSLRTVGPYT MAGAASSIAA NRISYTFDLR GPSMAIDTAC
     SSSLVALDHA CRTLQEGTSR VAVCGGANVL LSPFHYVGFS QAAMLSRAGR CASFSAEADG
     FVRAEGGGVV LLKRLTDALA DGDRVHGVIL GTGANSDGRT MGMSLPSAEA QEDLLRRVYA
     QAGVHPDELV YFEAHGTGTP VGDPLEAQAI GRALGIRRIT GDLPIGSVKS NLGHLEPASG
     MAGLFKALLV LRHGLAPASL HAEPPHPDID FAGLGLNVTS RNQPVVRVDR PVVGVNSFGF
     GGANAHTVLG CAPPSPQAPS VTAAEDGLPV LVSARTEQAL VQATAMMADH LASMAPEQFY
     DLAHTCCLRR GRHEHRAVVM ARTPQEAAQE FAALSRSGDP DAARQDHAVG GEPEPTTECR
     GAQPPIGSFR PAGATARVAA GGRVAFVFSG NGSQWAGMGA DLFAHHPDFR QEIERVDAAL
     APHLDWSMAE VFATPPEAWR LAETETAQPM LFAVQAGLTA VLRGQGIEPA MVVGHSVGEV
     AAAYCSGAYT LAQAARVVAA RSRAQGRTAG RGRMAAIGLP AEQALAELAR QSGPLELAGV
     NSPQDVTVAG ESAALAAFES ELRGRGVFCR DLGLDYAFHS KAMDDLREEL TTTLADLAPG
     PVAVPFYSTV TGQRVRGADL DADYWWQNVR LPVRFDAAIR RVVDDGAGLL VEIGPHPVLR
     TYLRRIAATR PTLTTVVLPT LRRAQDGPQA VATTLASSIA AGAVIDWRRY FPHPGRVTDL
     PAYPWQRERH WSGTAQSWIN SSGNGLLQHP LLGERLPAPV PVWEGAIEPT LVPWLADHRI
     SGSVIMPATG YVEMALAAGR TVLGRSVEVE HLDISNALVI PWADASAIRT QVSLNPDDGT
     LLITSIGEHS EEPRPHARAR VRAQLRPRPA PLDLNALKKR CAARVTADAF YESCAKAGLV
     YGPTFQVLRN IWTGEGTAVA SYCHEAPETA YTAHPALLDA ALQTGVALLV QRLLDGHAYL
     PSAITAVRVW GELTETGHMW VRERLRSHDE VCWDIVITDD QGQVTAQLDG CLLNRLTAGH
     GTPTTVHETV LRAAPYPDVP CAPSPLPPPE DVVAATSERI DEVRTAWRHM RYPHFAGLFK
     RIAACHAASA VAGLLTDPAA PFTMDDLVTT GMAARHRGLM DVLATLMERH GHLAVEPDGR
     WRLTPQTDRA DELMREAATR TPAFVHQLAL AAHQGRHLGA LLRGEAPAGT AAEPTANLLE
     QYQEAAPAHR FHNRLVQSLV GEAIRDWPAD RTLRVLEIGA ASGGVTAALL PMLPPERTRY
     TFTDPSAASL ARARSRFSPY DFIDYRTLGL DADPAEQGFT HHGYDIVIAA NSLRGTADLQ
     AAVRRVALLL APGGHLLGIE CHDPEMLAPI VGTLGGFPAR TDTEPPQDCI LTPHESWAGL
     LKECGFTEVV RSGADSEPAF TDHSMFLAST PREPVPQPGL PDATAGTSFL VVTEAEGEQP
     LARAVADALT ERGSRARLVP GEAEARDENH LLCANDLAGT DLAVVLLLAD AGEARADVLV
     AQAARRADLL RSIAAECARL PRGSRAALWL VTRPSGALPD PAGITHPGDA AMWAVMRCLA
     NEQPELTGRR VSLARSHDPA ADALRLTREL LFADGEDEIV LTVADRFVPR EQPLSVPRHG
     AGTGPFALRV HHPGLSYRLV WEEMASPQPG PGQVAIDVRA VGLNYRDVMQ AVGLLPAEAR
     EDVPREVDLG LECSGVVSAC GPGVTVFAPG DRVAGMVRAS MGSSTVTMAR SIRRIPDHMS
     FAEAATAPTA FSTIHYSLSH LARVQPGETV LVHGAAGGVG LAALQYARAH GAEVIATAGS
     DVKRDFLRGL GVRHVLDSRS MDYVNEVREI TRDQGVDVVL NSLAGEGITR GVELLRPGGR
     FIELGKRDMY EGKPLTLRPF LNNIAFYGVD LTSMDDPRLV GPLEVAADAI AGSGVYHPLP
     YTVFPAARVE DAFRLMQHSR HIGKVVITFD ALDESPNVVP LPRALRLDPE GTYLVTGGNS
     GFGAATAAWL ADQGARHLAL VSRRGADAPE AADALSAVAD RGADAVALAV DVTDVDAMRA
     LIDSIDAGGH PLRGIVHCAM HLDDAPLSEL THDRFAAVLA AKMGGAAILD TLTQGRNLDL
     FLLYSSTTAM IGNFKQSSYA AANLYLEALA RQRRQRGESG VAIAWGAIGE TGYAARNDLL
     SSFQALGIEP LAPHAAFATM EHLLADGNRA AEVAGITCCN WTRTGALLPL LSSARLTDLV
     PAHTDEGDLS REELLRTISL MTSEEALDSL TEQLTRLLGE ALGLDPDQLD PHRRLDAYGM
     DSLMAAQVLV SLNQRYDIDI PPMELLRSNG TIVEFAQIVQ LRLGFHTSAD PT
//
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