ID D7DJ46_METV0 Unreviewed; 2044 AA.
AC D7DJ46;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) {ECO:0000313|EMBL:ADI30081.1};
GN OrderedLocusNames=M301_1701 {ECO:0000313|EMBL:ADI30081.1};
OS Methylotenera versatilis (strain 301).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylotenera.
OX NCBI_TaxID=666681 {ECO:0000313|EMBL:ADI30081.1, ECO:0000313|Proteomes:UP000000383};
RN [1] {ECO:0000313|Proteomes:UP000000383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 {ECO:0000313|Proteomes:UP000000383};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Clum A., Land M., Hauser L., Kyrpides N., Ivanova N.,
RA Chistoservova L., Kalyuzhnaya M., Woyke T.;
RT "Complete sequence of Methylotenera sp. 301.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADI30081.1, ECO:0000313|Proteomes:UP000000383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 {ECO:0000313|EMBL:ADI30081.1,
RC ECO:0000313|Proteomes:UP000000383};
RX PubMed=21622745; DOI=10.1128/JB.00404-11;
RA Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT "Genomes of three methylotrophs from a single niche uncover genetic and
RT metabolic divergence of Methylophilaceae.";
RL J. Bacteriol. 193:3757-3764(2011).
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DR EMBL; CP002056; ADI30081.1; -; Genomic_DNA.
DR STRING; 666681.M301_1701; -.
DR KEGG; meh:M301_1701; -.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG5000; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_233220_0_0_4; -.
DR OrthoDB; 9813903at2; -.
DR Proteomes; UP000000383; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 6.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 9.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 8.
DR PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08447; PAS_3; 3.
DR Pfam; PF08448; PAS_4; 2.
DR Pfam; PF13426; PAS_9; 3.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00086; PAC; 7.
DR SMART; SM00091; PAS; 8.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 8.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 6.
DR PROSITE; PS50112; PAS; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000383};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 356..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 381..433
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 501..555
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 556..628
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 632..685
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 686..758
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 762..815
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 826..867
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 884..936
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 937..1009
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1013..1066
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1487..1533
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1560..1612
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1644..1782
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 1791..2044
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 2044 AA; 231423 MW; D78747FB6BB09F2D CRC64;
MWSRFPNMNV GRKLMLIVVA SVLLVIIPAA AGIYLYLKQN LLATEAATLT NETQTIVASN
TQTLLGYEFS LKALSNTLEK TLAEPPKVGE AAAFDQLVQR YPDRAWRNRR EGFDGRTEAG
VFLPPDAVLD AEQKSLHLRS KHLLDIYGTS ITNAYGNIWL LTKDKTEVIY DHLYPEFAAL
MKADTDYTST AWFTLGDPAT NPKREVRWTP PLLDPVSSSW IISAVLPLDI NGRWIGTIGR
DISITKALPS LMQKSQRYSG EQHLLMDAQG NYIDAGPWQK QLVAHPDTFK LDLAQEPELA
ELLRHKALAL STHLYDKHVK IDGREYLVID AHMPYLDWRY IRLVPVNEIL APMRQLFYSL
IGIVLAIGLL IGFLIDLAVQ RNIIKRLQTL ADAVRRYGLG DMKARANLLG SDELAKTSQE
FDTMAKCIES NERELNLVMN NIPVMASRVD KNLRYVFVSH QYTTIFAKSM QEIVGHTMQE
ILGEDLFAQE EPYARGAIAG EAVNFEIKSE ILGYGEMYGL VHFIPNLDEN NQLDGFFISV
VDITELKKIQ QDLMERDARW KFAIEGFGDY LWDSDEVSRT ITYSKAWIDI VGYAEDELDH
KLNEWESRIH PDDKVAVFAN LQSCLDGDTP TYDCEYRILC KNNSYKWIHD RGIVLDRSVN
GKPLRMVGTA SDISLRKQLE VELKAKDDRW KFAIEGSGDG VWDWDIQSNT IEHSARWKEI
LGYSPSDTLP TGEDWENRFH PDDKARVAEA MRLYLEGKTS VYRVECRIKC KDGSYKWILG
RGMVVSRDED GKPLRMIGTS IDVSKRKQAE IELSIAATAF ESQQSIIIAD AKRKIVRVNS
EFTKTTGYTA EEVVGQSIDI LKSDKHDTAF YKTMWTTISH VGTWSGEVWN KRKNGDIYPG
QLTLTAVKDE HDNVSYYVGT VLDITERKKT EEALIESEYR SKFAIEGSGD GVWDVNVQTE
EATYSKRWAE MLGYEASEIL PTRDEWRALI HPEDKPRVLA AGTAYLEGKT EIYVVEYRIR
CKDGEYKWML SRGILVSRDE HGNPLRMIGT QIDITERKLA EEKLKRMQLE LLESHERYVD
LYEFAPIGYL SVTKHGMITE VNWKVTAMLG LQRKDINQHR FDEFVVDDDK SFWRRQFTMI
KEMQGGEELT LSLKLASANG SIFNANLHCL RMDDDDDQPI LRVTLEDVTQ LKQAEQVMQL
RESYQRSLLD NFPFMVWLKD KKHRYLAVNQ AFAKASGYDS ESLLPGLTDL EVWPKEVAKK
YRSDDIAVLK NGVPRASEEI VEINGRKNWY EIYKSPVTID GEVVGTVGFA RDINDRKHAE
MFEQFRSQIL ELLIADLTLQ NILEAIVLGV EQFNPEMLCS ILLLDAEGKH LGNTAAPSLP
TFYNAAIDGS EIGVGVGSCG AAAFTGELVI VEDIATHPYW EGYRDLALNS GLAACWSQPI
LAPSGKVLGT FAIYHRSPNT PTQRDITLIE QSANLASIAI ERKQAEDDLR IASIAFESQE
GMMVTDAKNI ILKVNQAFCD ITGYTSEEAV GHTPRLLSSS QHSEGFYDAM WECVHATGHW
AGEVYNRRKN GEVFPQHLTV TVVKDANGIV TNHVATLTDI TMNKAAAEEI KHLAFYDSLT
GLPNRRLMVD RLNQALVFNA RTGRDGAVLF LDLDHFKTLN DSLGHDVGDL LLQQVAERLV
SCVREGDTVA RLGGDEYVVL LESLSEDAPE AATQVEVIGE KILASLNQAY QLGQHEYHCT
PSIGVALFSN HNQSQEELLK HADIAMYQAK KAGRNTIRFF DPKMQEVINT RVDLERELRK
AIDKQQLHLY YQIQVDVAGR PMGAEGLIRW LHPEHGLVSP FHFIPLAEET GLILPIGQWV
LETACHQLKL WEKDEMTSAL TLSINVSAKQ FRQADFVNQV QEAVQRYDVN PMLLKLELTE
SMLLDNIEDT VTTMNRLKEV GIRFSLDDFG TGYSSLQYLK RLPLYQLKID QSFVRDIAVD
SSDQAIVRTI VAMAHTLNLN VIAEGVETEE QQGLLLNNGC THYQGYFFGR PVPIEQFEVL
LKSH
//
