ID D7DMX4_METV0 Unreviewed; 332 AA.
AC D7DMX4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Trans-hexaprenyltranstransferase {ECO:0000313|EMBL:ADI28913.1};
DE EC=2.5.1.30 {ECO:0000313|EMBL:ADI28913.1};
GN OrderedLocusNames=M301_0529 {ECO:0000313|EMBL:ADI28913.1};
OS Methylotenera versatilis (strain 301).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Methylophilaceae; Methylotenera.
OX NCBI_TaxID=666681 {ECO:0000313|EMBL:ADI28913.1, ECO:0000313|Proteomes:UP000000383};
RN [1] {ECO:0000313|Proteomes:UP000000383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 {ECO:0000313|Proteomes:UP000000383};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Clum A., Land M., Hauser L., Kyrpides N., Ivanova N.,
RA Chistoservova L., Kalyuzhnaya M., Woyke T.;
RT "Complete sequence of Methylotenera sp. 301.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADI28913.1, ECO:0000313|Proteomes:UP000000383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 {ECO:0000313|EMBL:ADI28913.1,
RC ECO:0000313|Proteomes:UP000000383};
RX PubMed=21622745; DOI=10.1128/JB.00404-11;
RA Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT "Genomes of three methylotrophs from a single niche uncover genetic and
RT metabolic divergence of Methylophilaceae.";
RL J. Bacteriol. 193:3757-3764(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|ARBA:ARBA00006706, ECO:0000256|RuleBase:RU004466}.
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DR EMBL; CP002056; ADI28913.1; -; Genomic_DNA.
DR RefSeq; WP_013147229.1; NC_014207.1.
DR AlphaFoldDB; D7DMX4; -.
DR STRING; 666681.M301_0529; -.
DR KEGG; meh:M301_0529; -.
DR eggNOG; COG0142; Bacteria.
DR HOGENOM; CLU_014015_2_0_4; -.
DR Proteomes; UP000000383; Chromosome.
DR GO; GO:0000010; F:trans-hexaprenyltranstransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR12001:SF87; OCTAPRENYL DIPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000000383};
KW Transferase {ECO:0000256|RuleBase:RU004466, ECO:0000313|EMBL:ADI28913.1}.
SQ SEQUENCE 332 AA; 35577 MW; 2F085E6933011F34 CRC64;
MTQSNTSSSS SPLNTIQSCI AADILAVNTV ITHSLHSEVT LVNQVAHYIV NSGGKRLRPI
LVLLSGGLFG EVKPEHHQLA AVVEFIHTAT LLHDDVVDES SKRRGQNTAN AIFGNAASVL
VGDFVYSRAF QMMVAVQNMR VMEVLSNATN VIAEGEVLQL LNIHNADVTD GAYLQVIHYK
TAKLFEAATR LGAIISNASP SDEEALSQYG MHIGTAFQLI DDVLDLSGNA SEIGKNLGDD
LSEGKPTLPL LYAMRNGTAD EAETIKRAIE HGGLEDLVTV LSAVERTGAL DHVRKVAAKE
SELACAAIAH FADSPYKQAM LTLAEFAVAR NY
//
