ID D7FRN9_ECTSI Unreviewed; 658 AA.
AC D7FRN9;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0000259|SMART:SM01117};
GN ORFNames=Esi_0217_0002 {ECO:0000313|EMBL:CBJ30830.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ30830.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ30830.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
CC {ECO:0000256|ARBA:ARBA00038357}.
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DR EMBL; FN648395; CBJ30830.1; -; Genomic_DNA.
DR AlphaFoldDB; D7FRN9; -.
DR STRING; 2880.D7FRN9; -.
DR EnsemblProtists; CBJ30830; CBJ30830; Esi_0217_0002.
DR eggNOG; KOG1110; Eukaryota.
DR InParanoid; D7FRN9; -.
DR OrthoDB; 148785at2759; -.
DR Proteomes; UP000002630; Unplaced LGUn.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 3.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR PANTHER; PTHR10281:SF72; LD12946P; 1.
DR PANTHER; PTHR10281; MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR SMART; SM01117; Cyt-b5; 3.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 414..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..152
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|SMART:SM01117"
FT DOMAIN 234..294
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|SMART:SM01117"
FT DOMAIN 548..656
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|SMART:SM01117"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 69944 MW; 745E012A238811DD CRC64;
MPAECSVSSA EDTGGRSETA LDGGDAEATK LVRRNFTVRQ LNAFDGGCSA PRMRGGEARA
VKQRPIYIAL KGEVYDASAG RHLYGPGGEY SEFAGHDISR RVAHGASRSD RSSSTLLDDL
SLEGLGRFEQ MTLRGWEDTF RARGYPSLGR VVAPPPPRLF SRAELRAFDG RPADVAASEH
GETERGAGAG GGEREVGGGE PGEQAAVLAR QEEQPAESLP PEQEAKATAN AVYFSNYAAQ
PIYMGVKDKV FDVSFGGSEF YLEGGPYECL AGRDASRVLA KMSMASEDIE GVLDYSCLTD
REEKNLADWV EKLGEGGKGY LPRHPTDRPG VRCGISFWPQ GGPEASLSTL DRCLGAQSHV
AVEKHQARDM GEILRRVQVY RVSTPEEVAA VSAVGPAAAV PPASEPAELV TMRVVILLGG
VAVGIGMFAI FWAWCYAEHR LWQLESAAAP PAGDGIDQPL LAAHEEQEEC CSCPMDALEA
QQQRSDEAAR AASVGAPTDS TSSVPSVDST SSLAPAPAAA AAASSSREGE EEEVTAAVQP
IRPLLRDFTI AELNTFDGGE SPLSRKPHPI FISLRGTVYD ASNGRGIYGP SGELAAFPGH
DVSRGVARGL VASKEDGKSD LDDLSLTGLN RIERMTLAGW EERFKACGYP VVGRVVLQ
//
