ID D7FT64_ECTSI Unreviewed; 2238 AA.
AC D7FT64;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=E3 ubiquitin-protein ligase Nedd-4, putative {ECO:0000313|EMBL:CBJ49236.1};
GN ORFNames=Esi_0245_0029 {ECO:0000313|EMBL:CBJ49236.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ49236.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ49236.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648426; CBJ49236.1; -; Genomic_DNA.
DR EnsemblProtists; CBJ49236; CBJ49236; Esi_0245_0029.
DR eggNOG; KOG1729; Eukaryota.
DR InParanoid; D7FT64; -.
DR OrthoDB; 1334597at2759; -.
DR Proteomes; UP000002630; Chromosome LG33.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR39490; ARRESTIN DOMAIN-CONTAINING PROTEIN D; 1.
DR PANTHER; PTHR39490:SF12; FYVE ZINC FINGER FAMILY PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 5..38
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 156..218
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1332..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1396..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1515..1544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2041..2086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2238 AA; 225054 MW; 234CEEFDA7BCA6E1 CRC64;
MATLPPLPEG WEERRDEQGH TYYVDHNTRR SSWRDPRLVQ TGGPPPPAAT AAAGVPAPPT
VAPTNNGGGG SKSFFNRSSA NRKQPTVGMS ESTSSLEPRK QNGAAAGPDS PRRRRSMPVP
RSGGGGGGGG GGGKGGAGPV DKSREDIAFS PHLIPDDDRS QCSVCGERFA ALRRRHHCRC
CGELVCATCS PTKLLMHVSE PGYERPRRAC QTCAAHIAAG EYSCNSRYAL AIATPGADMY
HKQAAVRHLS AAMEDAAKNA VKSGGGGGGG DGGGGGVLGP LSAIQRVHGG TPAVFQALVP
MMSTEVPLDV CTHACQLLGA SLFVASRQSS PETWVGLVKV IPEGCVDGLL ECLRVAPARA
KAARALFYAA KVPLAGGTGG ELIESRGGVS IMLEVLESLP LAPPPTAAVE TKGLRVWLCA
TLQPVMADRP RAVQAFLACR GIPLLCRQLA AGPADIAVHV CGVLASALRS GGAGAGAGSS
AAVPRSAIET VDASIIDPLL GMLAGGTNKD AHASALAMEL LVVLASHPPF SGRLRAAGTI
PAVAACLEDH PARGAAAAAA EPVARASLMQ LALIVLTGFL RGDGDQPAAV AATGEVDEVA
AEIAATRAHV RVVALLSAPD PKLRFTAAEL ALQLSRRCRP GPAPNSNRGG GGGGIAKDMI
EAGGLGALWS ACSDPSPMAR PVALEALAAM LGTAAAMSRS SASSEAVLAL VSEGAVGGLV
RQHVDPALSV LGRRGRGVTV ALLDAGGSSG RGGFLSTDSE ALSSAKLTRA AIRVVWSLSR
GPSSATLAAH GTLPRLMGHM SCLRRKGSGG GGADGARGDT AAGVLVLDTI AAFLSLEDSS
SGHRRGGSKD SVAPVPPSTA TTIGRTVDEL CELVLHGTTT KRATADDAGD DGSSGAAAGS
LGPRSLALLA KAAANPRLRP MLVDSPKFPA VLDLLMVERH LDGASSVEAP RREEVCAGLR
VLAGLAAHEA CVPLVLESED LGCLLQGIPE GMTPTPAVGR ETPGGHGPPV RAQMREEMED
ALRCLLPLKG RPQQRSSLNR ALGLVATSPA HPGLDALLHL ASAEGGPALQ VVFQLVAADA
AKSVPSSPVL RPLGDGRHPA VLKGLLGPAD FPWQGGIGPS ARDSAVKAAR ARACDALRHA
CSELSPSSSS APAAARDTGN PTGDGGDSAE AGPGGNVTAG SGKLDVEAVA EVFPLVLPLA
GTTLEGARCL RAMFAARGGV GEAAQAAVLR RGVVGDAAGA GAGGIGAIVA MLHSTYVEIR
AAGASILRKL VFPTAAPTHR PEGGGQAAAA SIRPCRALLE SLHACGGRSE ALRSLSSFGL
FGEQDQAAVP GGTLSVIDNG GGGGGGGERA GSRKGSAGGG RRKGAAQEVR WRRQLRDDAA
AVLVAVVGAV TGGAGNGSGG GGASWRQRRR RRSSGEEAAE GLVGWNGGGE EGFDAQESEA
LSGVCVEALQ ALATDNFTGP LEKARCLSLL ADLALDPRCA RTLFQGGAIP QMLLNAQGCT
HVDLIDVHGD RGGGGGGGFV GGSDGRASPA PSATSCDSEE EGEEEEEVVV VVEEEEEERQ
RVAVGVSGSV TTAGAVCCRC RQATRLLARL VRGLPGETPA VVVRHSGLRS VVQILEDGAA
EAKAATEGTG GRIPTATEAA VREALELFVA LSEQKPHRGA LADLPGLARS ASSYIVSATT
ASTSSSSPQA GEDSSAEESA FRLLANLAFA DAPRRRVLEL DGLVLASARA LSASALALAP
PTQKEAPAAA AAALAVAVGA GEAAAALLCR LSPVLGADGG EEELVAAGEA LSAAVAAVSM
AAAGRDFTAA TAGGLASEAL YALLVLSWAD SSSLDAAAAV DGFVTDSRFA DSVVSLWRRG
MAPSASSGFG ALSETALATM SSIAARPTGR KSLVAAGAAS AVVDVALGRQ GGGGDVAGDS
EGGCSQTMMM APQLSVSERG EIIRLLCVLC ASPAHRGAVR SSLMAKRGVE SGGDDTEEAA
VEAAIVRIQG GRGGGGGGEE CRAGARRLAL LLGVSPPSRR SSQHRGGTTA GAGAFAAEYL
SSGDHRRTPF RSPPTGDAVI KRRSTSTTTR SPSPPPPPAY AGDSRAAAAG LEDDIASSVD
LEEALFPTAT ATAVAHLGSP GARDTLSRAA VAVAPVASAR APAAGRRDHA LLTFPAPKNG
RSDSEESLHR LLSMIANEDN SSAAAASATA NGSLSGAVVG AEERDDKIAC ESCGKLVFAP
TGFDLALIEC PHCQKPMG
//
