ID D7FX85_ECTSI Unreviewed; 890 AA.
AC D7FX85;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Excinuclease ABC subunit C {ECO:0000313|EMBL:CBJ49263.1};
GN ORFNames=Esi_0320_0009 {ECO:0000313|EMBL:CBJ49263.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ49263.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ49263.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648510; CBJ49263.1; -; Genomic_DNA.
DR AlphaFoldDB; D7FX85; -.
DR STRING; 2880.D7FX85; -.
DR EnsemblProtists; CBJ49263; CBJ49263; Esi_0320_0009.
DR eggNOG; ENOG502RRUF; Eukaryota.
DR InParanoid; D7FX85; -.
DR OMA; RPCLYHF; -.
DR OrthoDB; 5490540at2759; -.
DR Proteomes; UP000002630; Chromosome LG27.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 2.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630}.
FT DOMAIN 27..120
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 313..640
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT REGION 285..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 890 AA; 93831 MW; 86F4C0D200D444B6 CRC64;
MMTTKLPVLD PSRPRPRLRE CILGAPDEPG CYIFESGDGR KLYIGKSVNL SSRVQSYFSS
SSSAGNGAEH AVRPGRSLSR RIAVMTDLVE RIDYIVTASG AEALLLEASL IRQHQPPFNV
LLKDDKQNYP YVCVTWSEPY PRVLITRDKP RRGGGSEDRY YGPFVDAGQV KSTVALVRRV
LPLRERARPL YKDKPCLNYD MGICPGPCQG LVSEEDYAET VRLAEMVFRG EGSQLLSTLQ
GRMESESRAE RFERAGEIKA QMTLVRGGLL GSSLHFSAGG VAAGGGGDRG GLQPRGDGAR
ASSAEGGGSR RDVVAVGLAG DLACFQVFQV RGGRLIGRLG FTYRVEEEGL SRGEVLQACL
ERYWGDVLMS ARTAAGGVGD ERGDNLPSRT LNGNPGAKGG RGGGFSVLHV PEEIVTADAL
PDGGAVLLAE LLSGARKAAA DAQRGAQATG PGEGGSPRDL TTEKATTGKT ARSKRSVDKS
YPPAVAVRVV HGESGAGERH HLCVMALKNA ELEAKRLLRG GESIARGLSQ LARMLGLGSN
PARIEGYDVS HTGGGNAVAS LVCFLDGKAS PKDHRRYRIR SPGIRKGHSD DYASLREVIA
RRFSPPTPSL RSPRPPSQAN PVPELVLIDG GKGQLAAALE GAAIAADAWL SVERGGTTTL
TGFDTEPAVG AAAAVDTKSP GAPPVESREL AGTPLLDDAV RRDEASWSAL PPLLGERTAQ
EEDPDAVLST AAVPPPEPSD GDVAGARSVG VGGGRRVTFV SLAKKEEEVY VPGSSEPLAA
ALEAGPSSPG VMVLRQVRDE AHRFAVAYHR KLRGNDMFLP GRGTVATEET DSVNGGGGQQ
DFAAIAGLSS KARHELTITF GSLEGARIAG EAELRRIPGI GPVLAKRILA
//
