ID D7G0J8_ECTSI Unreviewed; 712 AA.
AC D7G0J8;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Putative scytonemin-related tyrosinase {ECO:0000313|EMBL:CBJ33027.1};
GN ORFNames=Esi_0406_0019 {ECO:0000313|EMBL:CBJ33027.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ33027.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ33027.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
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DR EMBL; FN648604; CBJ33027.1; -; Genomic_DNA.
DR AlphaFoldDB; D7G0J8; -.
DR EnsemblProtists; CBJ33027; CBJ33027; Esi_0406_0019.
DR eggNOG; ENOG502SM4K; Eukaryota.
DR InParanoid; D7G0J8; -.
DR OMA; ENCTCAC; -.
DR OrthoDB; 324607at2759; -.
DR Proteomes; UP000002630; Chromosome LG09.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 2.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..712
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003096039"
FT DOMAIN 532..543
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
FT REGION 60..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 80092 MW; A523F917D869ADCA CRC64;
MTTMRSVAGL LLLISRADPK PIPVVPTGAF GVDDSSGVPR QRQQEPPVTA FGEAVHALDP
ARARPSDAAI PGWEEDSTPS GEQAHDEETS VLSLTATNGY PDIVWSPWVH LAEPHRATVL
RAESQVGNPN DDVFLWTIPN ENGASFEGRE IEYIFTDPGR KDIVLTQTVT STGERYSLHT
YIMVKYVRRE IRALNNADRV AFFDTLETLY RLPTSQGVEE FGTDYKGIDY FVQMHLDGAG
VKDCDHWHDD AGIMTHHVGY TLQFEQAMQL VNPSVSIPYW EYTIEATEGL PSYGESTVFN
DDWFGEFSPR NELHTVTKGR WAFLPIQPDA WDSVHNPYGL LRSPWNLNPT PFVTRHNATS
SMSATAMVSC SVYLSCFDST TLADMNSCLN GETHGPVHIL AGGEWHAAEE DFIQKVGYYE
SVPLVTKFLW RKGYLSIPDT CDQGTPCQTS CPAKLYESKG MTPYDVLLDV HALMWTAHTS
ASLVYNSKKD KFEVKGHEDD ESFQQAFFKK MLNSFCNPGN VGEMYTSAAP YDPLFWVIHP
TADRLLAWRR MLGRQGAEGW DFDETWGYAH SSVVGETGTV CNWDDVVPGS GDMPTCVKGI
CGGHNEDDLL PFSVKINGEV MKLTNAGWMD LIYPTNEDLP YMYDEFKWTH CRVHLKKREY
RDHWVREVVR AVVRRGPNPE RCLGRGRRRK HFKLNIDSAA IITLTQGTIR DA
//
