ID D7G2W7_ECTSI Unreviewed; 570 AA.
AC D7G2W7;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Transient Receptor Potential Channel {ECO:0000313|EMBL:CBJ48824.1};
GN ORFNames=Esi_0049_0030 {ECO:0000313|EMBL:CBJ48824.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ48824.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ48824.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FN648696; CBJ48824.1; -; Genomic_DNA.
DR AlphaFoldDB; D7G2W7; -.
DR STRING; 2880.D7G2W7; -.
DR EnsemblProtists; CBJ48824; CBJ48824; Esi_0049_0030.
DR InParanoid; D7G2W7; -.
DR Proteomes; UP000002630; Chromosome LG14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:CBJ48824.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 229..354
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 396..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 62516 MW; E5FECF863F328B27 CRC64;
MRPFEKRPQS KSRLEANPSR REDQGLVYSI TTDIGVFNSG LNFNLCGMLA ILGGPDVMTD
AVRSVSLRFN TYNGQCDGLF SFVDITALFT LGGEVKMVTS VEVFSMPFFF GSSPAIVGRA
IAMFAFGLML VIYIGKDVLR AWREVRDGRH RLSMSLRHVP VTTATALNLV GDCVFLWNLV
LWVNVAVTAA KFELIPTLSY NNASEQVRAF SEELALVALE RWKRDAAAVA GSIFGLTRLF
IMLRFHPRLS LVTDVLTASA VHLVHFFIMF FMVVGVYSNL VWVIFGPSSL LFATWTKSFV
TMTRIALGEF DNIYPLMVEI DGAAAFMIIV TYQTLQCILL LNIVISILLD AFQMVQKRNS
VVAADTLWQT VMTTLGRWRI RLTHVGFALV GRCPSVTRRS SPRGSSVGDD AGTTVVKNPM
HDRHGGRKLR QRHQHTAPTA GGTSAAAVAA AAGVPVAPPG ITGSSSRGVP LLPSSDKRKV
SSKNRGGGAT KRGGLTRGQR LAMSHRHYDL RTAVEVLRRS PLPEAAVWRK MRQIIGARLG
WVSEGAGNTG KPLQPGAAWG RSQSRRFSKR
//
