ID D7G395_ECTSI Unreviewed; 2492 AA.
AC D7G395;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Possible MAPK {ECO:0000313|EMBL:CBJ26942.1};
GN Name=MAPK {ECO:0000313|EMBL:CBJ26942.1};
GN ORFNames=Esi_0050_0096 {ECO:0000313|EMBL:CBJ26942.1};
OS Ectocarpus siliculosus (Brown alga) (Conferva siliculosa).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; PX clade; Phaeophyceae;
OC Ectocarpales; Ectocarpaceae; Ectocarpus.
OX NCBI_TaxID=2880 {ECO:0000313|EMBL:CBJ26942.1, ECO:0000313|Proteomes:UP000002630};
RN [1] {ECO:0000313|EMBL:CBJ26942.1, ECO:0000313|Proteomes:UP000002630}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ec32 / CCAP1310/4 {ECO:0000313|Proteomes:UP000002630};
RX PubMed=20520714; DOI=10.1038/nature09016;
RA Cock J.M., Sterck L., Rouze P., Scornet D., Allen A.E., Amoutzias G.,
RA Anthouard V., Artiguenave F., Aury J.M., Badger J.H., Beszteri B.,
RA Billiau K., Bonnet E., Bothwell J.H., Bowler C., Boyen C., Brownlee C.,
RA Carrano C.J., Charrier B., Cho G.Y., Coelho S.M., Collen J., Corre E.,
RA Da Silva C., Delage L., Delaroque N., Dittami S.M., Doulbeau S., Elias M.,
RA Farnham G., Gachon C.M., Gschloessl B., Heesch S., Jabbari K., Jubin C.,
RA Kawai H., Kimura K., Kloareg B., Kupper F.C., Lang D., Le Bail A.,
RA Leblanc C., Lerouge P., Lohr M., Lopez P.J., Martens C., Maumus F.,
RA Michel G., Miranda-Saavedra D., Morales J., Moreau H., Motomura T.,
RA Nagasato C., Napoli C.A., Nelson D.R., Nyvall-Collen P., Peters A.F.,
RA Pommier C., Potin P., Poulain J., Quesneville H., Read B., Rensing S.A.,
RA Ritter A., Rousvoal S., Samanta M., Samson G., Schroeder D.C., Segurens B.,
RA Strittmatter M., Tonon T., Tregear J.W., Valentin K., von Dassow P.,
RA Yamagishi T., Van de Peer Y., Wincker P.;
RT "The Ectocarpus genome and the independent evolution of multicellularity in
RT brown algae.";
RL Nature 465:617-621(2010).
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DR EMBL; FN648708; CBJ26942.1; -; Genomic_DNA.
DR EnsemblProtists; CBJ26942; CBJ26942; Esi_0050_0096.
DR eggNOG; KOG0593; Eukaryota.
DR InParanoid; D7G395; -.
DR OrthoDB; 316889at2759; -.
DR Proteomes; UP000002630; Chromosome LG09.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24055; MITOGEN-ACTIVATED PROTEIN KINASE; 1.
DR PANTHER; PTHR24055:SF566; OS02G0492300 PROTEIN; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002630};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 812..1206
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 2357..2435
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1356..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1690..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1744..1764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..548
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1270..1285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1364..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1472..1492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1523
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1690..1706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1744..1758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 2426
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 2492 AA; 268908 MW; 63F674DDEFD89657 CRC64;
MPPPGRRRPR PNLVNASAVS RGSQPAWFLR KREEGWNSRF ASDGPSYFDV PGAMALGDGA
SRTRPDMTKV TGAGGGSSVG VGFSSSDKPA GKRMRIRRDM TPSLSRGGTD APGARVSRRD
LYLMEKMYPE NPNLAITAGS AAASVAAGAR GAQRHQGSIG YPTPGDVRDD TRSPPPQYGN
SATGFHGQDH SNQGEVVQGG GKASLERNAT KLLAKLHALV EDWPTRSHAH SERRGQQQQQ
QQGRSKGHKK GRTKSKAKEK KASTGGIGEA MHARSSADVA AGCDRSCVEK IVAWSLVVSP
ESCRPKPFRW SSEDYLAKMH HDLDFVSDAL AKDAPAFGKG NPLLLTRSEA AGQPRAGQVG
RYYAATYVIL DAVNRARDAA TAAQAGDPPG ERAQEAGVHV SRRGKGYAGG GADGVGGGGL
GVVVIASDDE SLSKAGGLVG GEGVERRKRK KQKPRTQRVP KEQTMQQQEQ AQEVGKQQQR
LEQLERDQAG KRADPHTGGL LEGGDGLLDL GEEVGEETLS PKNTLDDEED LSDAYGESFE
EYEEYGQDDT TSPEIGTPQL QEDHDSSEAQ QFQGKGGQLS GSHEHLLATQ LDKEAEEARE
LREAEQLKAR EADEAHERRL RQEEEEEEEK EKESRRLREA EEQQVREKEA EEAHLKEEES
RRNREEEQHR ERKANEAHEQ RLRKEKEEEE DRLRMQEAER QRVLEEAAEE VRREEEEGRR
LREAEAEEAR LKDEESHRLR EIDQQRERQQ AEAYEQRLQE EEAQRLFEAE QLRNEEEGVS
GADEPQYHAN SDVGPGEQEQ EDVGMPTRIG DYDVDSLLGD GAYGWVYKCY RRRRSICSTT
GGSVRRNTET DGDDDDITAV VAIKQFKGLT DMEDEHTRNY VRLTQEREAD LALSLIHPNI
VRCLGTINAG GTCVASGDGG VGREEVAFLI FEHVPGTLLD LIQEHPGGLS LLETTNLLGQ
LLSAVDFLHQ HGVVHRDVKP ENILVDKKKT KGGVPTLKLC DLGTARKASE IGQEFNSRDT
IARSADDTTR DTPRTWTEYV GSRWYRAPEM LAGSTHYGAE VDVWACACLA AEMSSGRPLF
PGEDEGELAA SMAALLGPLP LDLASRLREM GYTPPPPRGR PTRSIEACLD GSTGTHEARR
SNPRGSRVGG SGFDADTLGI ASAEVGESEE QRQHYRGVLE ILGGMLVFDP ASRLSAQECL
LRASVFGSGS ADADASFAGR KPSAGDLGDF ETRRASTTRS SRGCSSSATK TYGSGATAGA
VVGGDDGSSL TNDSKDDDEH QEDQTISATS EAVSAGNDGR EPADIVAGPF KAGEGFTVGS
KSPSQFEAPV PPPQETTFLG EEGYVQKRVA EIEEKVEYYN PGNKTNAAKG QAPTETMEED
SVRTIATTEA AGEATLDRSD ASSVNGEGGG GPTEQGQRSA EGAPAAGTSP PSSGETRTIS
DPSTALDSRI AESATVEGET TAQAAEGVVD TTRADEVGDE DGETKRWGGR EGGQKKGNTS
DNSDDGYFLA DDGLEKSAEG DNKGNEQKGV MSFGDEDYGS DSFDEGEQHE EDQEGALTTR
GGRTSFFPNP PELSAAVDAV LEAEPSEITQ SINDNTAAAS LDETEEASLQ HAAPRAVDIE
DTADATASNS KPDADKDDEG KTEEVTKGME EDEAENGDGW RVTGAFRVLS ASGPWGEMAV
NAVKGLLRQP RDQQHQQQQR QGGSTTPVAG VGYEDNGKVT ALFQKALEAR GETGGHVRRS
MERAFASAST SEEPNTATET GDKAAVPAPN GVGKALEAFA AAAVAAEGEG LAVSRLARLT
AGLARCVDGE LQEAAQTCQA WAAHARQGKR PAHTGDPLLE CAEHLNSSCP IRQTKISTVG
GDGGGDSGVR GAVDGVGGVC ADFLAALCEA ADRGRSSATA DIVHASSTLE TLSRVVCSLA
PFILDADRPK VERDENLISV ATSLGLDEGL ARKTLRPPSL ASSYFLSPAG QAVLLKAALT
QRGERRINLV TTREEALEQI QGALERDLPP PDRDGRGDVG GSNTITSGVA PLAEALILNP
YYLSSWGNKK VLGQCVEEGE GLGPRKELFE LASRQLSERW RSPQTGLFSS PMKATARGRT
AEVDLVISFS ASDAPERAFY SRVKAGWRIK VGSQTRILGS VKVEEGIGGD DSSRYSARVT
KLWVDGFQSE EAHLQEASCP VLVYQEGSES KWLDAKADRS NDEHRKRLRT LGALLALSVT
NSCRLPVELP DLFFRWLLLG GESAVVKQKH GQQLSPSCPS FEPSVEDMVA LDKSLERPFE
ALKDAVQSDD ALKGLLEIED LPADTSAADY IAHMGSRGEL QQKDKWRHDG KDFDFRVAFS
VYEDRELVTC VPLHEAFWSV VQIELSPEER RRLLLFITGT DRLPEAGCET LSIEIPFEVP
GGSKDIETAR LAATKSLGQV PTAHTCDNIL ELPNYWMLLM RHEGRDEKTQ LSDVSVGDVS
LVVLDEGLNT PTWSQPHGVY VGGIRRPNGI EE
//
