ID D7GPI2_9FIRM Unreviewed; 459 AA.
AC D7GPI2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN ORFNames=CK3_33040 {ECO:0000313|EMBL:CBL42717.1};
OS butyrate-producing bacterium SS3/4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=245014 {ECO:0000313|EMBL:CBL42717.1, ECO:0000313|Proteomes:UP000008961};
RN [1] {ECO:0000313|EMBL:CBL42717.1, ECO:0000313|Proteomes:UP000008961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS3/4 {ECO:0000313|EMBL:CBL42717.1,
RC ECO:0000313|Proteomes:UP000008961};
RG metaHIT consortium -- http://www.metahit.eu/;
RA Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT "The genome sequence of Clostridiales sp. SS3/4.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CBL42717.1, ECO:0000313|Proteomes:UP000008961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS3/4 {ECO:0000313|EMBL:CBL42717.1,
RC ECO:0000313|Proteomes:UP000008961};
RA Pajon A.;
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
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DR EMBL; FP929062; CBL42717.1; -; Genomic_DNA.
DR AlphaFoldDB; D7GPI2; -.
DR KEGG; bprs:CK3_33040; -.
DR PATRIC; fig|245014.3.peg.1931; -.
DR HOGENOM; CLU_012893_0_0_9; -.
DR BioCyc; BBAC245014:G1314-2839-MONOMER; -.
DR Proteomes; UP000008961; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd13143; MATE_MepA_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR045070; MATE_MepA-like.
DR InterPro; IPR048279; MdtK-like.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 459 AA; 50040 MW; 8950AF0B00B45BAF CRC64;
MKRIDFENGT ITGNILGAAL PMLIAQILNL LYNIVDRIYI ARIPEIGTAA LGAVGLCFPI
IVIITAFSNL FGTGGAPLFS IFRGKKDSDT AKRIMNTSFT MLCVCATILM AVGFLFARPI
LILFGASAEA IIYAYPYMML YLIGTLPSMI AVGMNPFINA QGYSSIGMLS VAIGAGTNLV
LDPLFIFALG LGVRGAAIAT VISQCLSAAF VLFFLTKKSE LKLRFLHKNE IPECSEHARN
ILSLGAAGFI MQLTNSLVTI CCNNILSVTG GDIYISVMTI ISSVRQLVEA PIHAMVEGTS
PILSYNYGAR RPGRVRKSIL IMSLLVFGYT AVMWSMIILI PETLIRIFSS DAALIQDAVP
ALNMYFAAFI FMDLQYIGQA VFKSLNKKVF AIFFSLLRKV FIVVPLTYFL PYVMHMGTDG
VFLAEPVSNV IGGTACILTM LITIMPELKR IEVENRRAE
//
