ID   D7GVC0_9FIRM            Unreviewed;       425 AA.
AC   D7GVC0;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Malic enzyme {ECO:0000313|EMBL:CBL41762.1};
DE            EC=1.1.1.38 {ECO:0000313|EMBL:CBL41762.1};
GN   ORFNames=CK3_21660 {ECO:0000313|EMBL:CBL41762.1};
OS   butyrate-producing bacterium SS3/4.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=245014 {ECO:0000313|EMBL:CBL41762.1, ECO:0000313|Proteomes:UP000008961};
RN   [1] {ECO:0000313|EMBL:CBL41762.1, ECO:0000313|Proteomes:UP000008961}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS3/4 {ECO:0000313|EMBL:CBL41762.1,
RC   ECO:0000313|Proteomes:UP000008961};
RG   metaHIT consortium -- http://www.metahit.eu/;
RA   Pajon A., Turner K., Parkhill J., Duncan S., Flint H.;
RT   "The genome sequence of Clostridiales sp. SS3/4.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBL41762.1, ECO:0000313|Proteomes:UP000008961}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS3/4 {ECO:0000313|EMBL:CBL41762.1,
RC   ECO:0000313|Proteomes:UP000008961};
RA   Pajon A.;
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the malic enzymes family.
CC       {ECO:0000256|ARBA:ARBA00008785, ECO:0000256|RuleBase:RU003427}.
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DR   EMBL; FP929062; CBL41762.1; -; Genomic_DNA.
DR   AlphaFoldDB; D7GVC0; -.
DR   KEGG; bprs:CK3_21660; -.
DR   PATRIC; fig|245014.3.peg.705; -.
DR   HOGENOM; CLU_034446_2_1_9; -.
DR   BioCyc; BBAC245014:G1314-1869-MONOMER; -.
DR   Proteomes; UP000008961; Chromosome.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR015884; Malic_enzyme_CS.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PRINTS; PR00072; MALOXRDTASE.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00331; MALIC_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU003427};
KW   Oxidoreductase {ECO:0000313|EMBL:CBL41762.1}.
FT   DOMAIN          49..182
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          194..418
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
SQ   SEQUENCE   425 AA;  45482 MW;  A41CA69BC95ABB22 CRC64;
     MKKYGCQKWQ NVSHSVYETG RQFSNENEFA GGSAMNFNEA ALKLHEEHHG KIEVVSKVPV
     KTRDDLSTAY TPGVAEPCRK IHDNKKDVYK YTAKGNLVAV VSDGTAVLGL GNIGPEAAMP
     VMEGKAVLFK EFGGVDAFPI CLDTTDTEEI IKAVKYIAPC FGGINLEDIA SPKCFEVEAR
     LEKELDIPVF HDDQHGTAVV VTAALLNALK VVGKKIDEIH VVLNGPGSAG TAIIKMLLAT
     GVKNIIACDE NGILYKDRGV GIKDHKKMLC DITNLEDKRG TLADALVGAD VFIGVSVAGA
     LKPEMIKTMA KDPIVFAMAN PNPEIMYDEA MAAGVKVMGT GRSDFPNQIN NVLAFPGIFR
     GALDCGARDI NYDMKVAAAQ AIAELVTPDK LSAEYIIPGA LEEGVAEHVA KRVAEAAVKS
     GAIRK
//