ID D7JC92_9BACT Unreviewed; 493 AA.
AC D7JC92;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
DE EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
GN ORFNames=HMPREF0156_00093 {ECO:0000313|EMBL:EFI16511.1};
OS Bacteroidetes oral taxon 274 str. F0058.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=575590 {ECO:0000313|EMBL:EFI16511.1, ECO:0000313|Proteomes:UP000004685};
RN [1] {ECO:0000313|Proteomes:UP000004685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0058 {ECO:0000313|Proteomes:UP000004685};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S.K., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A., Bochicchio J., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroidetes bacterium Oral taxon 274 strain
RT F0058.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000171,
CC ECO:0000256|RuleBase:RU004479};
CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00005113, ECO:0000256|RuleBase:RU004479}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004480}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|RuleBase:RU003954}.
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DR EMBL; GG774889; EFI16511.1; -; Genomic_DNA.
DR AlphaFoldDB; D7JC92; -.
DR STRING; 575590.HMPREF0156_00093; -.
DR eggNOG; COG2986; Bacteria.
DR HOGENOM; CLU_014801_4_0_10; -.
DR OrthoDB; 9806955at2; -.
DR UniPathway; UPA00379; UER00549.
DR Proteomes; UP000004685; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR005921; HutH.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR NCBIfam; TIGR01225; hutH; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Histidine metabolism {ECO:0000256|ARBA:ARBA00022808,
KW ECO:0000256|RuleBase:RU004479};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU003954};
KW Reference proteome {ECO:0000313|Proteomes:UP000004685}.
SQ SEQUENCE 493 AA; 54008 MW; 471F4D7527F17EAC CRC64;
MKIHQISTKH LSIDDVKRIV SEDYKIALSP EARKRIQDCR DYLDRKMETQ KEPIYGVTTG
FGSLCNISVG KEELSQLQKN LVMSHACGTG ERVPKEIVKI ILLLKIQSLS YGYSGVQLET
VEKLVYMFNE DILPVVYQQG SLGASGDLAP LAHLSLPLLN LGEVYVDGEV RAASEVMAQR
GQQPIVLKSK EGLALLNGTQ FMSGYAVWCM IGAEQISAAA DTIGALSLEG FDGRVEPFNE
AVHLIRPHNG QLQTAARIGE LLKGSQIIGQ KKTHVQDPYS FRCMPQVHGA SKDTIAYVKS
VVTTEINSAT DNPNVIPEKD LIVSAGNFHG QPLALVMDFL AIAVAELGSI SGQRTYQLIS
GKRNLPPFLV ANPGLNSGFM IPQYTAASIV SQSKQLCTPA SVDSIESSQG QEDHVSMGAN
AATKLYRVVE NTFRVLGIEL FNAAQALEFR RPLKSSATLE KLYANYRRTV PFVENDEIMY
PLIAKSVEFV KTM
//
