ID D7JDJ2_9BACT Unreviewed; 368 AA.
AC D7JDJ2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Thiazole biosynthesis protein ThiH {ECO:0000313|EMBL:EFI17091.1};
GN ORFNames=HMPREF0156_00681 {ECO:0000313|EMBL:EFI17091.1};
OS Bacteroidetes oral taxon 274 str. F0058.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=575590 {ECO:0000313|EMBL:EFI17091.1, ECO:0000313|Proteomes:UP000004685};
RN [1] {ECO:0000313|Proteomes:UP000004685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0058 {ECO:0000313|Proteomes:UP000004685};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S.K., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A., Bochicchio J., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroidetes bacterium Oral taxon 274 strain
RT F0058.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; GG774889; EFI17091.1; -; Genomic_DNA.
DR AlphaFoldDB; D7JDJ2; -.
DR STRING; 575590.HMPREF0156_00681; -.
DR eggNOG; COG0502; Bacteria.
DR HOGENOM; CLU_046249_1_0_10; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000004685; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000004685};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 70..291
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 368 AA; 42532 MW; 3A4E3AA320B0C183 CRC64;
MTFYDHIKPL DWNQTTDDIL SKTADDVRRA IDKRYRNLDD FEALISPAAR PFLEEMAREA
RRQTLERFGN VVQLYIPLYL SNYCHNSCVY CGFSTRNKIA RKMLTLDEVA AEAEAIKKLG
YKHILLVSGD APSMTNARYY NEVIKNIKND FSQISLEVQP LETEEYAILR STKLDYVCIY
QETYNESRYP VYHIGGRKAD FRYRLETPDR IGRAGIHKIG IGALLGLEDW RTEAFCTATH
LRYLQKTYWQ TRYSISLPRL RPIVGGYEPA SPVSDRDLVQ LICAYRLLDR DVEISLSTRE
SAEFRDNVFP LGITSMSAGS STEPGGYANT EHRLEQFEIN DSRSPEEFAA ALRAKGYEAV
WKDWDVWM
//
