ID D7JE26_9BACT Unreviewed; 519 AA.
AC D7JE26;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN ORFNames=HMPREF0156_01004 {ECO:0000313|EMBL:EFI17407.1};
OS Bacteroidetes oral taxon 274 str. F0058.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=575590 {ECO:0000313|EMBL:EFI17407.1, ECO:0000313|Proteomes:UP000004685};
RN [1] {ECO:0000313|Proteomes:UP000004685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0058 {ECO:0000313|Proteomes:UP000004685};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Earl A., Feldgarden M., Gevers D., Young S.K., Zeng Q.,
RA Koehrsen M., Alvarado L., Berlin A., Bochicchio J., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Bacteroidetes bacterium Oral taxon 274 strain
RT F0058.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR EMBL; GG774889; EFI17407.1; -; Genomic_DNA.
DR AlphaFoldDB; D7JE26; -.
DR STRING; 575590.HMPREF0156_01004; -.
DR eggNOG; COG1620; Bacteria.
DR HOGENOM; CLU_021628_0_0_10; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000004685; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000004685};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 69..88
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 109..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 225..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 342..363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 383..409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 415..434
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 500..518
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 519 AA; 54555 MW; C141F1938CFBD2C7 CRC64;
MDILLSVFPI LLLFVLMLGV KMAGHKSAFL TLVATLLIAL IAAPALGFAP ENYTQGGVMW
AFLEGILKAT FPILIIILMA IYSYNTLLES GEIEVIKKQF TSLTNDRGVI VLLLVWGFGG
LLEGMAGFGT AVAIPAAILI GLGFKPGFSA LVSLIANSVP TGFGAVGVPV TTLANEVAPS
GCATPEAICD IASKVVIQLS PLMLLIPFVI LTLTDSSPKK IIKHILLSLW VGGISLVVQY
ICARYLGAET PAILGSVAAI LAIVVYARLF AGRRDAATSS VAEEPITLSR ALRAWSVYGF
ILFFILISGP LVKPVNEFLR THLVSNVHLP IYAEGKYFSF GWISNAGLML FLGTFIGGML
QGVSAKKLLV VLARTVKNLN KTVITIMSLV SIASVMNYAG MIGVIASALV AATGVYYPLF
VPLIGAVGTF VTGSDTSSNI LFGKLQANVA SQLSYPDPNW LVSANTAGAT GGKIISPQSI
AIATASCNMP GRDGEILRGA LPYAIGYIIL AGLMVYFAC
//
