ID D7KGA7_ARALL Unreviewed; 577 AA.
AC D7KGA7;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Exonuclease 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=ARALYDRAFT_889222 {ECO:0000313|EMBL:EFH66519.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; GL348713; EFH66519.1; -; Genomic_DNA.
DR RefSeq; XP_002890260.1; XM_002890214.1.
DR AlphaFoldDB; D7KGA7; -.
DR STRING; 81972.D7KGA7; -.
DR EnsemblPlants; scaffold_102016.1; scaffold_102016.1; scaffold_102016.1.
DR GeneID; 9326322; -.
DR Gramene; scaffold_102016.1; scaffold_102016.1; scaffold_102016.1.
DR KEGG; aly:9326322; -.
DR eggNOG; KOG2518; Eukaryota.
DR HOGENOM; CLU_008978_5_2_1; -.
DR OrthoDB; 126305at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035312; F:5'-3' DNA exonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd09901; H3TH_FEN1-like; 1.
DR CDD; cd09857; PIN_EXO1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR044752; PIN-like_EXO1.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF72; 5'-3' EXONUCLEASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 1..102
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 141..210
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
SQ SEQUENCE 577 AA; 64788 MW; 280BD80DE7CC1252 CRC64;
MGIKDLLRFM KPYILPIHIQ KYAGKRVGID AYSWLHKGAY SCSMELCLDT DGKKKLRYID
YFMHRVNLLQ HYEIIPVVVL DGGNMPCKAA TGDERHRKRK ANFDAAMVKL KEGNVGAATE
LFQRAVSVTS SMAHQLIQVL KSENVEFIVA PYEADAQLAY LSSLELEHGG IAAVITEDSD
LLAYGCKAVI FKMDRYGKGE ELILDNVFQA VDQKPSFQNF DQELFTAMCV LAGCDFLPSV
PGVGISRAHA FISKYQSVER VLSFLKTKKG KLVPDDYSSS FTEAVSVFQH ARIYDFDAKK
LKHLKPLSQN LLNLPVGQLE FLGPDLSPSV AAAVAEGNID PITMEAFNRF SVPRRQLQKP
VRSFKEQEKE SSFLVCSSSK SEERIELKRT ADEATIYPEA TLKKAMYSKQ DSDLHKLLSQ
PNRDQVVIQP SNPSLIPDNN PFKIRKTDEI NLEFAEYGLQ ELAVSFVTKS KAMDVASSSP
NSHGHEDREE GVTIDLPKLE DSGIKQDSAK NTVKETFETT EVDIAEVQDH VNMTTKRVRG
AKPRTESFKV KTNCKSAENK KTTIKKKHSI LDFFHRL
//
