ID D7KHZ2_ARALL Unreviewed; 793 AA.
AC D7KHZ2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 08-NOV-2023, entry version 64.
DE RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN ORFNames=ARALYDRAFT_888040 {ECO:0000313|EMBL:EFH68697.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC ECO:0000256|RuleBase:RU000617};
CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
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DR EMBL; GL348713; EFH68697.1; -; Genomic_DNA.
DR RefSeq; XP_002892438.1; XM_002892392.1.
DR AlphaFoldDB; D7KHZ2; -.
DR STRING; 81972.D7KHZ2; -.
DR EnsemblPlants; scaffold_100834.1; scaffold_100834.1; scaffold_100834.1.
DR GeneID; 9328500; -.
DR Gramene; scaffold_100834.1; scaffold_100834.1; scaffold_100834.1.
DR KEGG; aly:9328500; -.
DR eggNOG; KOG0967; Eukaryota.
DR HOGENOM; CLU_005138_4_0_1; -.
DR OrthoDB; 961at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblPlants.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblPlants.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR GO; GO:0080111; P:DNA demethylation; IEA:EnsemblPlants.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:EnsemblPlants.
DR GO; GO:0000012; P:single strand break repair; IEA:EnsemblPlants.
DR CDD; cd07900; Adenylation_DNA_ligase_I_Euk; 1.
DR CDD; cd07969; OBF_DNA_ligase_I; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR000977; DNA_ligase_ATP-dep.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR InterPro; IPR036599; DNA_ligase_N_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR00574; dnl1; 1.
DR PANTHER; PTHR45674:SF4; DNA LIGASE 1; 1.
DR PANTHER; PTHR45674; DNA LIGASE 1/3 FAMILY MEMBER; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF04675; DNA_ligase_A_N; 1.
DR SUPFAM; SSF117018; ATP-dependent DNA ligase DNA-binding domain; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000617};
KW DNA damage {ECO:0000256|RuleBase:RU000617};
KW DNA recombination {ECO:0000256|RuleBase:RU000617};
KW DNA repair {ECO:0000256|RuleBase:RU000617};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU000617};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000617};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000617};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 527..663
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 64..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 793 AA; 88040 MW; ACE39A227700F6BD CRC64;
MLAIRSSNYL RCLPSLCTKT QISQFSSVLL SFSRQVSHLR LSSCHRAMSS SRPSAFDALM
SNARAAAKKK TPQTTTSSRS PNKRKIGETQ DANLGKTLVS EGTLPKTEDP VEPISDSAKP
RSDTSSIAED SKTGTKKART LSKTDKIDEM KSKIGLLKKK PNDFDPEKVS CWEKGERVPF
LFLALAFDLI SNESGRIVIT DILCNMLRTV IATTPEDLVA TVYLAANEIA PAHEGVELGI
GEGTIIKAIS EAFGRTEDHV KKQNTELGDL GLVAKGSRST QTMMFKPEPL TVVKVFDTFR
QIAKESGKDS NEKKKNRMKA LLVATTDCEP LYLTRLLQAK LRLGFSGQTV LAALGQAAVY
NEEHSKPPPN TKSPLEEAAK IVKQVFTVLP VYDIIVPALL TGGVWNLPKT CNFTLGVPIG
PMLAKPTKGV AEILNKFQDI VFTCEYKYDG ERAQIHFLED GTFEIYSRNA ERNTGKYPDV
ALALSRLKKP SVKSFILDCE VVAFDREKKK ILPFQILSTR ARKNVNVNDI KVGVCIFAFD
MLYLNGQQLI QENLNIRREK LYESFEEDPG YFQFATALTS SDIDEIQKFL DASVDVGCEG
LIIKTLNSDA TYEPAKRSNN WLKLKKDYMD SIGDSMDLVP IAAFHGRGKR TGVYGAFLLA
CYDVDKEEFQ SICKIGTGFS DAMLDERSSS LRSQVIATPK QYYRVGDSLN PDVWFEPTEV
WEVKAADLTI SPVHRAATGI VDPDKGISLR FPRLLRVRED KKPEDATSSE QIADMYQAQK
HNHPSNEVKG DDD
//