ID D7KTD7_ARALL Unreviewed; 991 AA.
AC D7KTD7;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=ARALYDRAFT_474976 {ECO:0000313|EMBL:EFH64196.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
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DR EMBL; GL348714; EFH64196.1; -; Genomic_DNA.
DR RefSeq; XP_002887937.1; XM_002887891.1.
DR AlphaFoldDB; D7KTD7; -.
DR STRING; 81972.D7KTD7; -.
DR EnsemblPlants; fgenesh2_kg.2__106__AT1G63740.1; fgenesh2_kg.2__106__AT1G63740.1; fgenesh2_kg.2__106__AT1G63740.1.
DR Gramene; fgenesh2_kg.2__106__AT1G63740.1; fgenesh2_kg.2__106__AT1G63740.1; fgenesh2_kg.2__106__AT1G63740.1.
DR eggNOG; ENOG502QQ7T; Eukaryota.
DR HOGENOM; CLU_001561_0_1_1; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR ExpressionAtlas; D7KTD7; baseline.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF294; DISEASE RESISTANCE PROTEIN (TIR-NBS CLASS)-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 1..133
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 991 AA; 113506 MW; 2E52317C63472509 CRC64;
MFDDQGIERG QTISPELTRG IRESRISIVV LSKNYASSSW CLDELLEILK CKEDIGQIVM
TVFYGVDPSD VRKQTGDIWK VFKKTCGGKT EEKRRKWSQA LNDAGNIAGE HFLNWDNESK
MIEKIGRDVS NKLNTTVSKD FEDMVGLETH LEKIQSLLHL DNEDEVIIVG ICGPAGIGKT
TIARALHSRL TCSFRRTCFM ENLRGSYNSS LDEHGLKLQL QEQLLSKILN QNGMRIYHLG
AIHERLCDQK VLIILDEVDD LKQLEALAND TKWFGPGSRI VVTTENQELL KQHGIKNTYH
VDFPTQKEAR EIFCRYAFKQ STPQDGFENL SERVTKLCSR LPLGLRVMGS YLLRKTEDDW
EDILYRLESS FDPVDRGIER VLRVGYDGLH EKNQLLFLLI AFFFNYKDED HVKAMLADNN
LNVRLGLKTL EYKSLIQKSS GGNIVMHKLL QQVGREAVQR QEPWKRQILI DAHEICDVLE
TDSGCANVMG ISFNVSTIPN GVHISAKAFQ NMRNLRFLSI YETRRDINLR VNVPENMNFP
HRLRFLHWEV YPGKCLPSTF RPEYLVELNL QNNKLEKLWE GTQPLTNLNK LELCGSLRLK
ELPDLSNATN LKRLDLTGCW SLVEIPSSVE NLHKLEELEM NLCLQLQVVP THFNLASLIS
LRMLGCWQLR KFPGISTNIT SLVIGDAMLE EMLESITLWS CLETLSIYGS VITHNFWAVT
LIEKMGTDIE RIPYCIKDLP ALKSLYIGGC PKLVSLPELP GSLRRLTVET CESLETVSFP
IDSPIVSFSF PNCFELGVEA RRVITQKAGQ MLAYLPGREV PAEFVHRAIG DSLTIRSSFC
SIFRICVVVS PKSGMKEEYV DLMCRKRING CPNGDNLFKA RLRKVQAEHL FIFQFEFLEE
DGWLEQDNEV LFKFTTSSQE LDIIECGIQI LTGETNRNIS SYESYESRSE QVSEYEDGYH
SDRRLEFHEQ KSLSRWGFCG IFHGFLRCFM A
//
