ID D7LAC5_ARALL Unreviewed; 3796 AA.
AC D7LAC5;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=FAT domain-containing protein {ECO:0000313|EMBL:EFH62396.1};
GN ORFNames=ARALYDRAFT_480691 {ECO:0000313|EMBL:EFH62396.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; GL348715; EFH62396.1; -; Genomic_DNA.
DR RefSeq; XP_002886137.1; XM_002886091.1.
DR STRING; 81972.D7LAC5; -.
DR EnsemblPlants; fgenesh2_kg.3__3392__AT2G17930.1; fgenesh2_kg.3__3392__AT2G17930.1; fgenesh2_kg.3__3392__AT2G17930.1.
DR Gramene; fgenesh2_kg.3__3392__AT2G17930.1; fgenesh2_kg.3__3392__AT2G17930.1; fgenesh2_kg.3__3392__AT2G17930.1.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0070461; C:SAGA-type complex; IEA:EnsemblPlants.
DR GO; GO:0000812; C:Swr1 complex; IEA:EnsemblPlants.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 2590..3133
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3424..3747
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3764..3796
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 169..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1932..1972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2220..2239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3179..3227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1935..1950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1951..1972
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2224..2239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3796 AA; 429348 MW; F9E99E185BCB5BEC CRC64;
MSPIQNFEQH SRRLVDPDLP IPTRLEMVVE VRDSLEIAHT AEYLNFLKCY FPAFSVILLQ
ITTPQFIDNP EHKLRNIVVE ILNRLPHSEV LRPFVQDLLK VAMQVLTTDN EENGLICIRI
IFDLLRNFRP TLENEVQPFL DFVCKIYSIF RSTVSHFFDN VKLEEVKPME MPTSSDQSLT
PTAPIGNGQL NPSTRSFKII TESPLVVMFL FQLYSRLVQT NIPHLLPLMV VAISVPGPEN
VPSHLKPQFI ELKGAQVKEL LVSLKHVLGT DFKRGLFPLI DTLLDERVLV GTGRACFESL
RPLAYSLLAE IVHHVRGDLS LAQLSRIIYL FSRNMHDSTL SLSIHTTCAR LMLNLVEPIF
EKGVDQQSMD EARILLGRIL DAFVGKFSTF KRTIPQLLEE GEVGKDRVTL RSKLELPVQV
PVEHSKEVND CKNLIKTLVM GMKTIIWSIT HAHLPRPQGF KGMREDEVWK ASGVLKSGVH
CLALFKEKDE EKEMLNLFSQ ILAIMEPRDL MDMFSLCMPE LFESMINNNQ LVQIFAALLQ
APKVCKPFAD VLINLLVSSK LDVLKNPDSA ATKLVLHLFR CIFGAVTNTP SDFERILQHH
VPVIMEVCMK NATEVDKPLG YMQLLRTVFR GLAGCKYELL LRDLIPMLLP CLNILLTMLE
GPAGEDMKDL LLELCLTLPA RLSSLLPYLP RLMKPLVFCL RGSDELVSLG LRTLEFWVDS
LNPDFLEPSM ANVMSEVILA LWSHLRPVPY PWGKKALQIL GKLGGRNRRF LKEPLTLECK
DNPEHGLRLV LTFEPSTPFL VPLDKFINLA VAAVIHKNHG MDIYYRKQAL KFLRVCLLSQ
LNLPGCVTDV GQTPRQLSTL LRSSVDSSWH RSESVEIKAD LGVKTKTQLM AEKSIFKTLL
ITILAASSDP DLSDTDDDFV ENICRHFAII LHVDYTSSNA STSTSSLGDS VISTSSRSRS
NQSSNLKQLD PLIFLDALVD VLADENRLHA KAALNALNVF AETLLFLALV KHADVLMARG
GHNASMIVSS PSTNPVYSPH PSVRIPVFEQ LLPRLLHGCY GSTWQAQMGG VMGLGALVGK
VNVETLCYFQ VKIVRGLVYV LKRLPVYASK EQEETSQVLM QILRVVNNVD EANSEARRKS
FQDVVEYLAT ELFNPNASIP VRKNVQNCLA LLASRTGSEV TELLEPLYQL LLQPLIMRPL
RSKTVDQQVG TVAALNFCLA LRPPLLKVTP ELVNFLQEAL QIAEADETVW AVKLMNPKVL
TSLNRLRTAC IELLCTTMAW TDFRTQTHNE LRAKIISMFF KSLTCRAPEI VAVAKEGLRQ
VINQQRMPKE LLQSSLRPIL VNLAHTKNLS MPLLQGLARL LELLSNWFNV TLGGKLLEHL
KKWLEPEKLA QSQKSWKAGE EPKIAAAIIE LFHLLPHAAS KFLDELVTLT IDLEAALPPG
QVYSEINSPY RLPLTKFLNR YAALAVDYFL SRLSEPKYFR RFMYIIRSDA GQPLREELAK
SPQKILSYAF PEILPKPDPT LSSAASTPPA TSSGDENHIS VKLESSNVAS TKANIASDAY
FQGLYLVKTM VKLIPSWLQS NRSVFDTLVL IWKSPARISR LQNEQELNLV QVKESKWLVK
CFLNYLRHEK SEVNVLFDIL SIFLFHSRID YTFLKEFYII EVAEGYPPNM KRALLLHFLN
LFHSKQLGHD HLVQAMQMLI LPMLAHAFQN GQTWEVIDPD IVKTIVERLL DPPEEVSAEY
DEPLRIELLQ LATLLLKYLQ SDLVHHRKEL IKFGWNHLKR EDSASKQWAF VNVCHFLDAY
QAPEKIILQV FVALLRTCQP ENKMLVKQAL DILMPALPKR LPLGDSRMPI WIRYTKKILV
EEGHSIPNLI HIFLLVVRHS DLFYSCRAQF VPQMVNSLSR LGLPYNTTAE NRRLAIELAG
LVVSWERQRQ NEMKMVPDTD GTSQITDELH TSGADPKRST DGSSTSEDPS KRVKIEPGLQ
SFCVMSPGGA ASIPNIETPG SATQPDEEFK PNAAMEEMII NFLIRVALVI EPKDRETNTM
YKQALDLLSQ ALEVWPNANV KFNYLEKLLS SMPPSQSDPS TALAQGLDVM NKVLEKQPHL
FIRNNISQIS QILEPCFKHK MLDAGKSLCS LLMMVFTAFP LDAANTPPDI KLLYQKVNEL
INKHVNTVTA PQASGDDNFF GSISFVLLVI KTLAKVHKNF VDSYVLVRIL QRLARDLGSA
VGSHPRQGQR TDSDSAVTSS RQTADVGAVI CNIKSVLELI DETVMLIADC KRSVTQILNT
LLSEKGTDAS VLLCILDMIK RWVEDDFSKT GASGLSGSFL TQKDVVTFLN KLSCIDKQHF
SSDALEEWDQ KYLQLLYGLC ADSTKYPLGL RQEVSLKVER HFMLGLRASD PEMRRKFFLL
YHESLGKNLF ARLQYIIQVQ DWEALSDVFW LKQGLDLLLA ILVEDKPISL APNSARVLPL
LPSDNPVIQH QASANLEGPE EVTSMFDSIV MKHAQFLSAT SKLQVADVVI PLRELAHTDA
NVAYHLWVLV FPIVWVTLLK EEQVALAKPM ISLLSKDYHK KQQGHRPNVV QALLEGLQLS
HPQPRMPSEL IKYIGKTYNA WHLALALLES HVMLFMNDSK CAESLAELYR LLNEEDMRFG
LWKKRSITAE TRAGLSLVQH GFWQRAQSLF YQAMVKATQG TYNNTVPKAE MCLWEEQWLH
CASQLSQWDA LVDFGKSIEN YEILLDSLWK LPDWAYLKDH VIPKAQVEET PKLRLVQSYF
ALHDRNSNGV GDAENTVGKG VDLALEQWWQ LPEMSVHARV PLLQQFQQLV EVQESARIHV
DIANGNKVSG NAAAGGLGNR YADLKDILET WRLRTPNEWD NMTVWYDMLQ WRNEMYNVVI
DAFKDFATSN SPLHHLGFRD KAWNVNKLAK IARKQGLYDV CVQILEKMYG HSTMEVQEAF
VKIREQAKAY LEMKGERASG LNLINSTNLE YFPDKIKAEI FRLKGDFHLK LNDTESANIA
YSNAITLFKN LPKGWISWGS YCDMAYQETQ DEIWLEYAVS CFLQGIRFGV SNSRSHIARV
LYLLSFDTAN EPVGRVFDKH LDQVPHWVWL SWIPQLLLSL QRTEAPHCKL VLLKIAAVFP
QALYYWLRTY LLERRDAVNK SEIGRLVLAQ RMQQNATGAS AGHGGSNLPS ETQIHRGAQI
SGAGGTHDSG NPHGQESERS TAENNVHPGS DQPMHQSSSA INDNNENTVR RNGASLAISA
AGAFDAAKDI MEALRGKHNN LASELEVLLT EIGSRFVTLP EERLLAVVNA LLHRCYKYPT
ATTAEVPQPL KKELSGVCRA CFSADAVTKH VEFVKEYKQD FERHLDPEST TTFPTTLAEL
TTRLKKWKNI LQSNVEDRFP AVLRLEDESR VLRDFNVVDV EIPGQYFADQ EVAPDHTVKL
DRVGADVPIV RRHGSSFRRL TLIGSDGSQK HFIVQTSLTP NARSDERILQ LFRVMNQMFD
KHKESRRRHI GIHTPIIIPV WSQVRMVEDD LMYNTFLEVY ENHCVRNDRE ADLPITHFKE
QLNQAISGQI SAEAIGDLRL QAYIDITKTL VNDSIFSQYM YKTLMSGSHM WAFKKQFAVQ
LAVSSFMSFM LQIGGRSPNK VLFAKNTGKM FQTDFHPAYD ANGMIEFNEP VPFRLTRNMQ
AFFSQFGVEG LLMSSMCSAA QAVISSKQNE HLRYQLAMFF RDELLSWFGR RPLGVPIPPV
GGIATLNSAE LKHKVNANVE DVIGRIRGIA PQYFSEEDEN TVEPPQSVQR GVNELVEAAL
SPRNLCMMDP TWHPWF
//
