ID D7LCU6_ARALL Unreviewed; 564 AA.
AC D7LCU6;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Methyltransferase type 12 domain-containing protein {ECO:0000259|Pfam:PF08242};
GN ORFNames=ARALYDRAFT_481476 {ECO:0000313|EMBL:EFH55205.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725}.
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DR EMBL; GL348716; EFH55205.1; -; Genomic_DNA.
DR RefSeq; XP_002878946.1; XM_002878900.1.
DR AlphaFoldDB; D7LCU6; -.
DR STRING; 81972.D7LCU6; -.
DR EnsemblPlants; fgenesh2_kg.4__536__AT2G26200.1; fgenesh2_kg.4__536__AT2G26200.1; fgenesh2_kg.4__536__AT2G26200.1.
DR Gramene; fgenesh2_kg.4__536__AT2G26200.1; fgenesh2_kg.4__536__AT2G26200.1; fgenesh2_kg.4__536__AT2G26200.1.
DR eggNOG; KOG2361; Eukaryota.
DR eggNOG; KOG2497; Eukaryota.
DR HOGENOM; CLU_022845_0_0_1; -.
DR OrthoDB; 5471626at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22809:SF5; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 79..180
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
FT REGION 262..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 63570 MW; 9877C27F93040AD9 CRC64;
MSAGLKIIEE QQKPIQKLQI YPTANAGVSP FWREKYERDA KKYWDIFYKH HGDRFFKDRH
YLDKEWNSYF SGSGKKVILE VGCGAGNTIF PLIATYPDIF VYACDFSPRA VELVKAHDEY
TETRVCAFAC DLTGDGLDKH ISPSSVDIVT MIFVLSAVSP EKMASVLQNI KKVLKPNGCI
LFRDYAVGDL AQERFSGKDQ KISENFYVRG DGTRAFYFSN EFLETLFSEQ GFEVEKLDVC
CKQVENRSRE LVMNRRWVQA TFRRSHGNQN PGDSLSPAKL DKSEQHDSIQ SKSEEQERKE
IIDNTDIDIS DGLAMEMFGA SPSSHEMTVV KLRDSDFKIK LLSKEYQHTC KSTGLMLWES
ARLMASVLDR NPNIVSGKRV LELGCGCTGI CSMVAARSAN LVVATDADTK ALTLLTENIT
MNLQSSLLGK LKTGVLEWGN KEHTESIKRL ACEGFEVIIG TDVTYVAEAI IPLFETAKEL
ILRKMGDLEM QEKPALILCH VFRRVDEPSL LSAASKYGFK LADRWAANSM ESPIGNIIDS
WFSEKDLVAE IPSSALHILY FQME
//
