ID   D7LK90_ARALL            Unreviewed;       652 AA.
AC   D7LK90;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=ARALYDRAFT_320670 {ECO:0000313|EMBL:EFH57272.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   EMBL; GL348716; EFH57272.1; -; Genomic_DNA.
DR   RefSeq; XP_002881013.1; XM_002880967.1.
DR   AlphaFoldDB; D7LK90; -.
DR   STRING; 81972.D7LK90; -.
DR   EnsemblPlants; fgenesh1_pm.C_scaffold_4000727; fgenesh1_pm.C_scaffold_4000727; fgenesh1_pm.C_scaffold_4000727.
DR   GeneID; 9317080; -.
DR   Gramene; fgenesh1_pm.C_scaffold_4000727; fgenesh1_pm.C_scaffold_4000727; fgenesh1_pm.C_scaffold_4000727.
DR   KEGG; aly:9317080; -.
DR   eggNOG; KOG0167; Eukaryota.
DR   HOGENOM; CLU_006348_5_1_1; -.
DR   OrthoDB; 103419at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd21037; MLKL_NTD; 1.
DR   CDD; cd16664; RING-Ubox_PUB; 1.
DR   Gene3D; 1.20.930.20; Adaptor protein Cbl, N-terminal domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR036537; Adaptor_Cbl_N_dom_sf.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR045210; RING-Ubox_PUB.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR23315; U BOX DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR23315:SF275; U-BOX DOMAIN-CONTAINING PROTEIN 12; 1.
DR   Pfam; PF00514; Arm; 2.
DR   Pfam; PF04564; U-box; 1.
DR   SMART; SM00185; ARM; 6.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51698; U_BOX; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          253..327
FT                   /note="U-box"
FT                   /evidence="ECO:0000259|PROSITE:PS51698"
FT   REPEAT          395..438
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          438..480
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          520..557
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          324..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   652 AA;  71621 MW;  83BFB2D41BB125D7 CRC64;
     MAKSEKHKLA QTLIDSINEI ASISDHHTPM KKHCGNLSRR LKLLIPMLEE IRDNQESSSE
     VVKALLSLKE SLVPAKDLLS FVSQVSKIYL VLERDQVMVK FQKVTALLEQ ALSGIPYENL
     EISDELKEQV ELVLVQLRRA IGKGGDVYDD ELYRDLLSLY SDIGSVTESD MLRSVAEKLQ
     LMTITDLTQE SLALLDMVSS SGGDPGESFE KMSMVLKKIK DFVQTDNPNL DDAPMRLKSR
     LPKLQDGDQD RPVPPEDFRC PISLELMTDP VIVSSGQTYE RECIKKWLEG GHLTCPKTQE
     TLTSDTVTPN YVLRSLIAQW CESNGIEPPK RPNNSQPSSK ASSSSSTPDD EHNKIEELLL
     KLTSQHPEDQ RSAAGEIRLL AKQNNHNRVA IAASGAIPLL VNLLTISNDY RTQEHAVTSI
     LNLSICQENK GRIVYSCGAV PGIVHVLQRG SMEARENAAA TLFSLSVIDE NKVTIGAAGA
     IPPLVTLLSE GSQRGKKDAA TALFNLCIFQ GNKGKAVRAG LVPVLMRLLT EPESGMVDEA
     LAILAILSSH PDGKSVVAAA DPVPVMVDFI RNGSPRNKEN AAAVLVHLCS WNQQHLIEAQ
     KLGIMSLLIE MAENGTDRGK RKAAQLLNRF SHFNDQQKQQ SGLGVEDQIS LI
//