ID D7LNS2_ARALL Unreviewed; 1017 AA.
AC D7LNS2;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=ARALYDRAFT_665139 {ECO:0000313|EMBL:EFH51920.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; GL348717; EFH51920.1; -; Genomic_DNA.
DR RefSeq; XP_002875661.1; XM_002875615.1.
DR AlphaFoldDB; D7LNS2; -.
DR STRING; 81972.D7LNS2; -.
DR EnsemblPlants; Al_scaffold_0005_1174; Al_scaffold_0005_1174; Al_scaffold_0005_1174.
DR Gramene; Al_scaffold_0005_1174; Al_scaffold_0005_1174; Al_scaffold_0005_1174.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 55..85
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 114..155
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 156..187
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 674..873
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 402..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 111177 MW; 44D486201C60C925 CRC64;
MIAEKPSWVK HEGVQIFSID VQPNGERFAT GGGDHKSVDK DLQNLDTKER LLATLRDHFG
SVNCVRWAKH SRYVASGSDD QVIQIHERKP GSGTTEFGSG EAPDVENWKA VMTLRGHTAD
VVDLNWSPDD SMLASGSLDN TVHIWNMRTG MCTTVLRGHL SLVKGVTWDP IGSFIASQSD
DKTVIIWRTN DWGMAHRTDG HWAKSLGSTF FRRLGWSPCG HFLTTTHGFQ KPKHSAPVLE
RGEWSVAYDF LGHSAPIIVV RFNHSMFKRI SSSTQETKQV GWSNGTSKTG GKDLQSYNVI
AMGSQDRTIT VWTTGSARPL FVAKHFFGQS VVDLSWSPDG YSLFACSLDG TVAMIHFDPK
ELGVRLTNTE LDELKKSRYG DVRGRQANLV ESPAQLLLET ASTKQAGSKR AASDVQQNEV
TTKPSASVES TAKRRKSQVD DPNKAAEATG HTLNKASTLN RVSSPVNQKV YRRPDGRKRI
IPEAVGVPQQ ENNITNNGQS HNFLPASAAA PSKGDSGDFP VEISNIDLSG KEIVCRNPDL
KERSRITARA TITESLIIEK VPGTSGRDGV LNVEQSVGIK ESSSTDLLIR VFDWKDGEAA
PPVCLEACPR EHALDTVGAI STSMVKETEI SCKKSGETLW SDRIIGRVTV LAGNPNFWAV
GCEDGSLQVY TKCGRRAMPT MMMGSAATFI DCDDSWKLLL VTRKGSLYVW DLFNRKCVLH
DSLSSLVSSN VNLSSTVEGT IKVISVKLSK SGSPLVVLAT RHAFLFDTSL MCWLRVADDC
FPASNFSSSW NLGSAPCGEL AGLQVDVRKY MARKPGWNRI TDDGMQTRAH LESQLASSLA
LESPNEYRQC LLAYVRFLAR EADESRLREV CESFLGPPTG MAEAASSDTN LSWDPYVLGV
KKHKLLRNDI LPAMASNRKV QRLLNEFIDL LSEYEDAETA DPAPKGSTPT MNCGGAPSSL
DQMGSDPPAL TATTPMTIDN DKPVSVANSA ALEIGVCEKP GSEDRDRQDQ NSRDSGS
//
