ID D7M1U8_ARALL Unreviewed; 355 AA.
AC D7M1U8;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Adenosine/AMP deaminase family protein {ECO:0000313|EMBL:EFH51076.1};
GN ORFNames=ARALYDRAFT_911747 {ECO:0000313|EMBL:EFH51076.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine;
CC Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842;
CC Evidence={ECO:0000256|ARBA:ARBA00036622};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16002;
CC Evidence={ECO:0000256|ARBA:ARBA00036622};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
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DR EMBL; GL348718; EFH51076.1; -; Genomic_DNA.
DR RefSeq; XP_002874817.1; XM_002874771.1.
DR AlphaFoldDB; D7M1U8; -.
DR STRING; 81972.D7M1U8; -.
DR EnsemblPlants; scaffold_603804.1; scaffold_603804.1; scaffold_603804.1.
DR GeneID; 9310884; -.
DR Gramene; scaffold_603804.1; scaffold_603804.1; scaffold_603804.1.
DR KEGG; aly:9310884; -.
DR eggNOG; KOG1097; Eukaryota.
DR HOGENOM; CLU_039228_3_0_1; -.
DR OrthoDB; 20281at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR CDD; cd00443; ADA_AMPD; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR11409:SF42; ADENOSINE DEAMINASE-LIKE PROTEIN; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 8..343
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 355 AA; 40102 MW; B780E22D226888DA CRC64;
MEWIKSMPKI ELHAHLNGSI RDSTLLELAR VLGEKGVIVF ADVEHVIRKN DRSLVEVFKL
FDLIHKLTTD HKTVTRITRE VVEDFALENV VYLELRTTPK RNDSIGMSKR SYMDAVIEGL
RSVSEVDIDF VTASDSQKLL NACDGIGRKK IYVRLLLSID RRETTESAME TVKLALEMRD
VGVVGIDLSG NPLVGEWSTF LPALQFAKDS NLHITLHCGE VPNPKEIQAM LDFKPHRIGH
ACFFKDEDWT KLKSFRTPVE ICLTSNIITK SISSIDIHHF ADLYNANHPL ILCTDDFGVF
STSLSNEYAL AVRSFGLSKR ETFALARTAI DATFAEDEVK QQLWLIFDSA SPEYA
//
