ID D7MHW9_ARALL Unreviewed; 867 AA.
AC D7MHW9;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=ARALYDRAFT_355577 {ECO:0000313|EMBL:EFH46711.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
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DR EMBL; GL348719; EFH46711.1; -; Genomic_DNA.
DR RefSeq; XP_002870452.1; XM_002870406.1.
DR AlphaFoldDB; D7MHW9; -.
DR STRING; 81972.D7MHW9; -.
DR EnsemblPlants; fgenesh1_pg.C_scaffold_7002750; fgenesh1_pg.C_scaffold_7002750; fgenesh1_pg.C_scaffold_7002750.
DR GeneID; 9304517; -.
DR Gramene; fgenesh1_pg.C_scaffold_7002750; fgenesh1_pg.C_scaffold_7002750; fgenesh1_pg.C_scaffold_7002750.
DR KEGG; aly:9304517; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_4_1_1; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblPlants.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR GO; GO:0080188; P:gene silencing by RNA-directed DNA methylation; IEA:EnsemblPlants.
DR GO; GO:0043633; P:polyadenylation-dependent RNA catabolic process; IEA:EnsemblPlants.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 475..555
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 645..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 97607 MW; 5B05D8B7A7257E63 CRC64;
MSDGTMDVDE SPVSWKVKSL ETLVDGSFSS TLSKLSSSSR LIPSSRDFHF YYNFDEFKRP
IDDIAGSSQS VLETIGDSEQ VWGKSMKFPG DVDEVDAEDW LCNVNDEFIE RFDVSVDEFQ
RIRKKEEEIG RPVAYNGDDG FQMVYGKKKK PVGNVITGLA ANGGSVIDVK MAERDKNSSG
KAKVPFHVPT IKKPQEEYNI LVNNANQPFE HVWLERSEDD QRVMHPLEKL SVLDFVDKDL
NEMEPVKPLP LEETPFKFVQ EVKDLKELVA KLRGVEEFAV DLEHNQYRSF QGLTCLMQIS
TRTEDYIVDT FKLRIHIGPY LREIFKDPKK KKIMHGADRD IIWLQRDFGI YVCNLFDTGQ
ASRVLNLGRN SLEFLLQHFC GVTANKEYQN ADWRIRPLPE EMTRYAREDT HYLLYIYDVM
RLELERMAKD DEHTDSPLLQ VYKRSYDVCT QLYEKELLTE NSYLHVYGLQ AAGFNAAQLA
IVAGLCEWRD FIARAEDEST GYVLPNKVLL EIAKEMPVSV GKLRRMLKSK HPYIERNVDS
VVSVIRQSMQ NSAAFESAAL SLKDVSPGTV MDKNIEHISE KKDMHAVDVA SPSLKENSSQ
LESTRDLNMD AANTNEGSGL GTGLFGSAKV SAAVRISKKP SSGLGALLGS AASKKKSRTD
EKVKEDVKLE QIRSSVNLSF HSFTEKVPDS KSTTETTPKV YGKPEEMFTT MQASVSKEDG
VTELKDDSEE ASEIVGTSGR VSESKVFGSK TGDIILLENG DEKEVEAEDE PMSLSELSTN
FQKCFKSMKK SNKAQKQTEF LNIEPFDYEA ARKEVKFGEG HKGRQGKKEV AAGQKKKGSG
PEQSEFGQGK RRQAFPASGN RSATFKS
//
