ID D7MKA3_ARALL Unreviewed; 1188 AA.
AC D7MKA3;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
DE Flags: Fragment;
GN ORFNames=ARALYDRAFT_494460 {ECO:0000313|EMBL:EFH39769.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; GL348720; EFH39769.1; -; Genomic_DNA.
DR RefSeq; XP_002863510.1; XM_002863464.1.
DR AlphaFoldDB; D7MKA3; -.
DR STRING; 81972.D7MKA3; -.
DR EnsemblPlants; fgenesh2_kg.8__276__AT5G45230.1; fgenesh2_kg.8__276__AT5G45230.1; fgenesh2_kg.8__276__AT5G45230.1.
DR Gramene; fgenesh2_kg.8__276__AT5G45230.1; fgenesh2_kg.8__276__AT5G45230.1; fgenesh2_kg.8__276__AT5G45230.1.
DR eggNOG; ENOG502SI7S; Eukaryota.
DR HOGENOM; CLU_001561_0_3_1; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 9..182
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 182..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1188
FT /evidence="ECO:0000313|EMBL:EFH39769.1"
SQ SEQUENCE 1188 AA; 134300 MW; 010135AAF7E456B2 CRC64;
MVTASDVKVG PEVFINFRGV ELRKTFISHL HTRLRRDGIN AFIDSDEAPG RELKNLFKRI
EDSKIALAVL SSRYTESHWC LQELVKMMEC SPKGEGCNNK LLVIPIFYKL KISTVAELDG
DFGRNLWDLW RLPGRGRDRD NRIVKWNEAL QDVLSRNALV LPETGKEDDF LSTIVAHVKN
ALSQITPQRG QNPKPQKGGG GGGNPKPQKF LSRASNITEP EDQRLKQLEV KLNVECNDNE
TRIVGVVGMP GIGKTYLARK LFVKLKKKIN HCVFIEFERE KSEEQGSEWL EKRLVESLLD
IKNCTDTNAL VVWKDSLINK KVTIVLDNVS EKKHWIKKGS KIVITTRDKS LTEGLVSDLY
EVPGLNERDG LELFRAQACC TLDGNFMELS RKFVDYAGGN PLALEQFGKE LRGKDVVHWE
TRLGTLAQCS NPTIREKLRS SYDELNELQK DAFLDIAYFF RSQDESYVRS LLDSCDPESA
ESGHEFRDLA DKFLIGVCDG RVEMHDLLFT MAKELVEATA DKSRLLLSNC AELRNKELSL
DQQGRDKVRG IVLDMSKMDE TPLKREVFVG MSSLRYLKVY NSLCPPHSET ECKLNLPDGL
EFPKDNAVRY LHWVKFPGTE LPSDFDPNNL IDLKLPYSNI ITVWICTKVA PNLKWVDLSH
SSNLNSLMGL LKAPNLLRLN LEGCTSLKEL PDEMKEMTNL VFLNLRGCTS LLSLPKITMD
SLKTLILSGC SKLQTFDVIS EHLESLYLNG TSINGLPPAI GNLHRLILLN LKDCKNLATL
PDCLWELKSL QELKLSRCSE LKMFPDVKKK VESLRVLLLD GTSIAEMPGN IFDFSLLRRL
CLSRNDNIRT LRFDMGQMFH LKWLELKWCK NLTSLPILPP NLQCLNAHGC TSLRTVASPQ
TLPTPTEQIH STFIFTNCHE LEQVSKNAII SYVQKKSKLM SADRYNPDFV FKSLIGTCFP
GCEIPAWFNH QSLGSVLTLE LPQDWNAAGK IIGIALCVVV SFKEYRDQNN SLQVKCTWEF
TNVSLSPESF MVGGWSEPGE ETHTVESDHT FISYTSLLTI KNRQQFPSAT EISLGFQVTN
GTSEVEKCKV IKCGFSLVYE PNEANNTSWK ETPRMEDNRQ DRRSSFKTGE GDDCPSGTPT
TADSNKGNGF LSSFWRDISI KKKGSLKIAN QIDVGMTYEE VHPNEVSE
//
