ID D7MQX5_ARALL Unreviewed; 220 AA.
AC D7MQX5;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=4a-hydroxytetrahydrobiopterin dehydratase {ECO:0000256|ARBA:ARBA00013252};
DE EC=4.2.1.96 {ECO:0000256|ARBA:ARBA00013252};
DE AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase {ECO:0000256|ARBA:ARBA00030497};
GN ORFNames=ARALYDRAFT_495179 {ECO:0000313|EMBL:EFH42102.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554};
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472}.
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DR EMBL; GL348720; EFH42102.1; -; Genomic_DNA.
DR RefSeq; XP_002865843.1; XM_002865797.1.
DR AlphaFoldDB; D7MQX5; -.
DR STRING; 81972.D7MQX5; -.
DR EnsemblPlants; fgenesh2_kg.8__995__AT5G51110.1; fgenesh2_kg.8__995__AT5G51110.1; fgenesh2_kg.8__995__AT5G51110.1.
DR Gramene; fgenesh2_kg.8__995__AT5G51110.1; fgenesh2_kg.8__995__AT5G51110.1; fgenesh2_kg.8__995__AT5G51110.1.
DR eggNOG; ENOG502QSK7; Eukaryota.
DR HOGENOM; CLU_113091_0_0_1; -.
DR OrthoDB; 394162at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:EnsemblPlants.
DR GO; GO:0009570; C:chloroplast stroma; IEA:EnsemblPlants.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblPlants.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009737; P:response to abscisic acid; IEA:EnsemblPlants.
DR GO; GO:0009651; P:response to salt stress; IEA:EnsemblPlants.
DR GO; GO:0110102; P:ribulose bisphosphate carboxylase complex assembly; IEA:EnsemblPlants.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR PANTHER; PTHR12599; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR PANTHER; PTHR12599:SF0; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
SQ SEQUENCE 220 AA; 23869 MW; BA8E06EFD5EF088F CRC64;
MAATSSSPPC NISVSSLLLR KPSCTILKVF GLLPPASRSN RKLGRLTVTR SNLAQDFLGD
FGARDPYPEE IASQFGDKVL GCQSTEHKIL IPNASVLSLS QLQCSPVSPS QPPLSADDAR
TLLHKVLGWS IVEDEAGGLK IRCMWKVRDS ECGVELINRI QKVAEASGHY PSLHVESPTQ
VRAELFTPSI GGLSMNDFIM AAKIDDIKTS DLSPRKRAWA
//
