ID D7MRE0_ARALL Unreviewed; 1185 AA.
AC D7MRE0;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=ARALYDRAFT_683354 {ECO:0000313|EMBL:EFH41444.1};
OS Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN [1] {ECO:0000313|Proteomes:UP000008694}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX PubMed=21478890; DOI=10.1038/ng.807;
RA Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT change.";
RL Nat. Genet. 43:476-481(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR EMBL; GL348720; EFH41444.1; -; Genomic_DNA.
DR RefSeq; XP_002865185.1; XM_002865139.1.
DR AlphaFoldDB; D7MRE0; -.
DR STRING; 81972.D7MRE0; -.
DR EnsemblPlants; Al_scaffold_0008_174; Al_scaffold_0008_174; Al_scaffold_0008_174.
DR GeneID; 9301259; -.
DR Gramene; Al_scaffold_0008_174; Al_scaffold_0008_174; Al_scaffold_0008_174.
DR KEGG; aly:9301259; -.
DR eggNOG; ENOG502SUNR; Eukaryota.
DR HOGENOM; CLU_001561_0_1_1; -.
DR OrthoDB; 684198at2759; -.
DR Proteomes; UP000008694; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF227; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000008694}.
FT DOMAIN 11..175
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1185 AA; 135486 MW; 05D8EEB63359F0B0 CRC64;
MASSSSSSRN WVYDVFPSFS GEDVRITFLS HFLKELDRKL IIAFKDNEIE RSQSLDPELK
QAIRSSRIAV VVFSEKYPSS SWCLDELLEI VRCKEELGQL VIPVFYGLDP SHVRKQTGQF
GEAFAKTCQR KTEDETKLWR QSLTDVANVL GYHSQNWPSE AKMIEAIANN VLGKLNFTPS
KDFEDFVGME DHIAKMSVLL NLESEEVRMV GIWGSSGIGK TSIARALYNQ LSRRFQGSVF
IDRAFVTKSK SNYESANPDD YNMKLYLLRS FLSEILDKKN VRINHLGAAE ETLNRRKVLI
FIDDMDDQVV LDTLAGQAQW FGCGSRIIVI TKDKHFLRAH RIDHIYEVCL PSKDLALKIF
CRSAFKKNSP PEGLMDLASE VALCAGNLPL GLKVLGSYLR GRDKEDLMDM LPRLRNSLDG
KIEKTLRVSY DGLNDKKDKA IFRHIACLFN GEKANDIKLL LADSGLDVNI GLKNLVDKSL
IHVRKEIVEM HSLLQEMGKE IVRAQSNEPG EREFLVDAKE ICDLLEDNTG TKKVLGISLD
MDEIDELHIH ENAFKGMRNL IFLKFYTKKW DQKNEVRWHL PEGFNYLPHK LRLLRLDGYP
MRHMPSNFRT ENLVELHMPG SKLERLWEGV QELKGLKTIN LHRSKNLKEI PNLSMATNLE
ELHLGDCSSL VELSSSVQYL NKLKSLVMSG CINLEILPTG INLQSLFSLN LKGCSGLKIF
PNISTNISWL ILDETSIEEF PSNLRLDNLL LLSMCRMKSQ KLWDRKQPLT PLMAMLPHSL
EELFLSDIPS LVDIPSSIQN FTHLDCLGIE DCINLETLPT GINFHHLESL NLSGCSRLKT
FPNISTNIEQ LYLQRTGIEE VPWWIEKFTK LDYITMEKCN NLIRVSLNIY KLKRLMVDFS
DCGSLTEASW NGSPSEVAMV TDNIHSKFPV LEEAFYSDPD STPPEFWFNF HFLNLDPEAL
LRQRFIFNSI TLSGEEVPSY FTHQTTEISL TSIPLLQPSL SQQFFKFKAC AVVSFDSLFL
TWGFGVYIRV NCRFKDRHGN SFDTFGQPHG FSGSKKDNNL FILDCRVPLN KDNAALAQLN
YDHVDMEIQI RKLDQSYKYG YTFKLKGWGI RVLEECSLLE NRLPHVYEAD EDNLVNMTEH
SEEYVETVVK RQRETGSDCI LPKGPLKKPL LCPASDTQEE NKTSL
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