ID   D7MU18_ARALL            Unreviewed;       870 AA.
AC   D7MU18;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=DUF4220 domain-containing protein {ECO:0000259|Pfam:PF13968};
GN   ORFNames=ARALYDRAFT_494436 {ECO:0000313|EMBL:EFH39736.1};
OS   Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81972 {ECO:0000313|Proteomes:UP000008694};
RN   [1] {ECO:0000313|Proteomes:UP000008694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. MN47 {ECO:0000313|Proteomes:UP000008694};
RX   PubMed=21478890; DOI=10.1038/ng.807;
RA   Hu T.T., Pattyn P., Bakker E.G., Cao J., Cheng J.-F., Clark R.M.,
RA   Fahlgren N., Fawcett J.A., Grimwood J., Gundlach H., Haberer G.,
RA   Hollister J.D., Ossowski S., Ottilar R.P., Salamov A.A., Schneeberger K.,
RA   Spannagl M., Wang X., Yang L., Nasrallah M.E., Bergelson J.,
RA   Carrington J.C., Gaut B.S., Schmutz J., Mayer K.F.X., Van de Peer Y.,
RA   Grigoriev I.V., Nordborg M., Weigel D., Guo Y.-L.;
RT   "The Arabidopsis lyrata genome sequence and the basis of rapid genome size
RT   change.";
RL   Nat. Genet. 43:476-481(2011).
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DR   EMBL; GL348720; EFH39736.1; -; Genomic_DNA.
DR   RefSeq; XP_002863477.1; XM_002863431.1.
DR   AlphaFoldDB; D7MU18; -.
DR   STRING; 81972.D7MU18; -.
DR   EnsemblPlants; fgenesh2_kg.8__252__AT5G45480.1; fgenesh2_kg.8__252__AT5G45480.1; fgenesh2_kg.8__252__AT5G45480.1.
DR   GeneID; 9301317; -.
DR   Gramene; fgenesh2_kg.8__252__AT5G45480.1; fgenesh2_kg.8__252__AT5G45480.1; fgenesh2_kg.8__252__AT5G45480.1.
DR   KEGG; aly:9301317; -.
DR   eggNOG; ENOG502QQBP; Eukaryota.
DR   HOGENOM; CLU_009180_3_0_1; -.
DR   OrthoDB; 414643at2759; -.
DR   Proteomes; UP000008694; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR025315; DUF4220.
DR   InterPro; IPR007658; DUF594.
DR   PANTHER; PTHR31325; OS01G0798800 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR31325:SF222; PROTEIN, PUTATIVE (DUF594)-RELATED; 1.
DR   Pfam; PF13968; DUF4220; 1.
DR   Pfam; PF04578; DUF594; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008694};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        16..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        47..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        89..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        118..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        142..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        300..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          52..485
FT                   /note="DUF4220"
FT                   /evidence="ECO:0000259|Pfam:PF13968"
SQ   SEQUENCE   870 AA;  100141 MW;  64BF3CD7485D1C9F CRC64;
     MVTAIPKPIK DIWDEWSIRS TLIFSLSLQT FLIFFAPQRK RSSKKALLFL IWSAYLLADW
     SANFAAGQIS DSQGNDPKPG DPKKSAELFA FWVPFLLLHL GGPDTITALA LEDNELWLRH
     LLGLFFQSVA TVYVLLQSLP NALWKATLLV FATGVIKYVE RTLALYLASL DKFKDSMIQR
     PDPGPNYAKL MEEYAAKKDM KMPTQIIKIG EPEKDPKASA QVRPEKLTPL NILQYAYKYF
     NIFKGLVVDL IFTFQQRAES KRFFDSLEAH EALRILEVEL NFIYAALYTK AEILHNWIGF
     IFRFIALGCL IAALRIFQYK SKKDYSGFDV GLTYALLLGG IALDSIALIM FCASDWTFVR
     LRKMKDEVDD PDTWSDHILN WILNNILGVR ELKTEEYDKC YKKTLSHEVP GTSTKKTPFL
     NWILWVRKLK TEKSHEVLDK STSETPGLEV PDKSAKKIPC HRVLDTSFMY RRWSEYVHAH
     NLIEYCLCLK PKRIHHTKGL IHIAFDKLIN ILYIGPTFTK FGSVIQSCFR VTKKTIHQTF
     KWIDGKISRF CKNHPKWNEE YIRLSFVCIF FFPSLPGRGI KRFMEFFGIR AQLDEVFYTS
     SDRLTLDMWE HIFREVKAKS RFADDSESAM RVSSARGDWT LRDIQGDPET EKKRDKLLRY
     VMEMDYDQSL LVWHIATELL YQTEDGTEAN HSNREYSKIL SDYMMYLLMM QPTLMSAVVG
     IGKIRFRDTC EEAQRFFDRR HIMGISAKKA PKEASDAILS VAVPVKAEPI DVKGDRSKSV
     LFDGAMLAKE LKGLSKNKEN NTEMWEIVSK VWVELLSYAA TKCGAIEHAA QLSKGGELIS
     FVWLLMAHFG LGDQFQINQG DARAKLIIGK
//